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Ilebo Biotechnology (Shanghai) Co., Ltd
Induced osteoporosis animal model
NegotiableUpdate on 05/06
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Overview
Induced osteoporosis animal model: The following is a comprehensive summary of the osteoporosis animal model, covering common methods, animal selection, and evaluation indicators
Product Details
Ilebo Biotechnology is a legitimate enterprise providing animal model services
Induced osteoporosis animal modelMain molding methods
1. Surgical method
(1) Ovary removal (OVX) model
-Applicable animals: female rats and mice.
-Mechanism: Simulating the increased bone resorption caused by estrogen deficiency.
-Characteristics: The model is stable, but there are differences in the rate of estrogen decline compared to the human menopausal process.
(2) Testicular Resection (ORX) Model
-Applicable animals: Male rats, simulating androgen deficiency osteoporosis.
2. Drug induction method
(1) Glucocorticoid model
-Medication:
-Mechanism: Inhibit osteoblast function and reduce bone matrix formation.
-Disadvantages: May cause side effects such as bone necrosis and immune suppression.
(2) Retinoic acid model
-Method: Administer 70 mg/kg orally for 10-14 days to induce bone loss.
-Application: Often used as a supplement to OVX models.
3. Nutrition/Dietary Guidelines
-Low calcium and low phosphorus feed: induces rickets or osteoporosis, and needs to be supplemented with deficiency.
-High protein feed: Protein>30% can increase urinary calcium excretion and promote bone resorption.
4. Physical Mechanical Method
-Hindlimb suspension: simulating disuse osteoporosis.
-Leg tail fixation method: suitable for local braking research
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