In vitro intestinal simulation system

In vitro intestinal simulation anaerobic fermentation device

(University Laboratory)/Research specific/Microbiology/Research on gut microbiota

The application and significance of product development:

1In the field of food nutrition, the development of new functional foods or health products requires human (animal) digestion reaction experiments to test their metabolic status and impact on human (animal) gastrointestinal microbiota; Food has a mutual influence on the digestion of food in human (animal) daily consumption;

2In the field of medicine, it is possible to conduct digestion reaction experiments on traditional Chinese medicine extracts or synthetic drugs. Monitor the chemical changes of traditional Chinese medicine components during the digestion process in the human (animal) body. At the same time, the effects of the main components of traditional Chinese medicine on the gut microbiota of humans (animals) can also be tested.

3Research field of human (animal) digestive tract diseases; Development and research of animal feed, etc.

Researchers typically conduct research in the aforementioned fields through live animals. not onlyHigh cost, poor repeatability, and unethical. ‍‍There is a way in ShanghaiWith the joint efforts of R&D personnel, we have innovatively developed the human bodyIn vitro intestinal simulation system，canReplace live animal experiments. Under the control of various high-precision sensors and precise execution units, it can highly simulate the process of human gastrointestinal digestion and absorption. Reduce experimental costs and achieve high reproducibility of experiments. Simultaneously avoiding harm to animals.

The main functions of the human in vitro digestion simulation system are:

1Control the constant temperature of the gastrointestinal tract; temperature30～40Controllable between ℃; Accuracy: ±0.1℃； intelligentPIDTemperature control; Adopting a brand new semiconductor waterless temperature control system;

2Control the physical and chemical environment in the gastrointestinal tract; Acidic, slightly positive pressure, anaerobic environment;

3Control the automatic detection and control of different simulated parts with varying acidity levels;

4Perform enzymatic hydrolysis reactions to simulate the secretion of digestive enzymes in the gastrointestinal tract;

5Detect the chemical changes of "food" during the digestion process;

6Simulate small intestine endocrine digestive enzymes to further digest and degrade substrates;

At the same time, provide an environment for the growth of various microorganisms in the human (animal) gastrointestinal tract;

7Simulate multiple absorption methods and perform active and passive absorption based on the absorption characteristics of different parts;

8The secretion amount and rate of digestive and secretion fluids can be regulated within a certain range0-1500ml/minThe parameters can be set and modified by oneself;

9Experimental repeatability deviation<1%Absorption deviation<2%；

10Easy to operate and assemble, the program can automatically analyze data and draw curves for customer use;

11The server adoptsWFCRemote communication mode;

12The client development adopts Siemens programmable field control+Dual monitoring and control on the upper computer end; adoptC#.withFramework 4.0Framework development.

13The device adopts dual screen data synchronization display, which is intuitive and convenient;

14Cloud based development system, which can also be used on mobile devicesAPPPerform operations and cloud data storage; Easy to use;

In vitro intestinal simulation device

In vitro intestinal simulation device