Cell energy metabolism analyzer

1、 Instrument Introduction

2、 Core performance

• 24 hole detection platformAdapt to standard cell culture and 3D sample system

• Dual parameter synchronous detectionReal time output of OCR (oxygen consumption rate), PER/ECAR (proton release/extracellular acidification rate), and ATP production rate

• Wide detection range：OCR 30–1050 pmol/min； PER 100–2500 pmol/min， Low signal stability, high signal does not overflow

• high sensitivityOCR detection limit is 30 pmol/min, PER is 100 pmol/min, and both trace samples and weak metabolism models can be accurately captured

• 4 integrated dosing ports per hole(50-100 µ L), supports real-time dosing, kinetics, and concentration gradient detection

• Wide temperature stable operationEnvironment: 4-30 ℃, cabin temperature: 16-42 ℃, meeting the needs of various cell and tissue models

• Specialized 3D consumablesAdapt to tissue sections, organoids, and spheres, fix samples without drifting, and ensure more stable signals

• Integrated softwareExperimental design, automatic QC, real-time curves, multi file analysis, one click export of charts

3、 Instrument advantages

1. Exclusive optimization for 3D models

   Specially designed consumables and workflows for physiological models such as organoids, tissue sections, and tumor balls, with data that is closer to the real state in the body.
   
   
   

2. Ultra high sensitivity and stability

   The low rate signal has minimal deviation, excellent inter board repeatability, and reliable results can also be obtained for trace/precious samples.

3. Real time unmarked, non-destructive testing

   No damage to cells, no need for labeling, long-term dynamic tracking of metabolic changes, and restoration of true physiological responses.

4. One machine covers complete metabolic research

   Simultaneously analyzing oxidative phosphorylation and glycolysis, supporting a complete set of standard protocols such as mitochondrial stress testing, glycolysis rate, substrate dependence, ATP rate, etc.

5. Full process automation

   One click completion of dosing, mixing, reading, quality control, and analysis significantly reduces human error and operational barriers.

6. Can be linked with Cytotion imaging

   Normalize cell counting, morphological assessment, and metabolic data to achieve more rigorous and convincing results.

4、 Application scenarios

• Tumor metabolismCancer cell metabolic reprogramming, drug resistance mechanisms, screening of metabolic target drugs, and research on tumor microenvironment

• metabolic diseases: obesity, diabetes, insulin resistance, lipid metabolism disorder, mitochondrial dysfunction

• neuroscienceResearch on the mechanisms of neuronal metabolism, mitochondrial damage, aging, and neurodegenerative diseases

• ImmunologyImmune cell activation, polarization metabolism regulation, target screening, macrophage function analysis

• Stem cells and regenerative medicineResearch on Stem Cell Dryness Maintenance, Differentiation Metabolic Switch, Tissue Repair, and Metabolic Remodeling

• drug developmentScreening of metabolic regulators, toxicity evaluation, mitochondrial safety assessment, evaluation of anti-tumor/hypoglycemic drugs

• Research on 3D Models: Organoid metabolic phenotype, tissue slice live metabolism, tumor drug response, co culture system analysis

Zebrafish (Beijing) Technology Co., Ltd. provides you with information on instrument parameters, prices, selection, technical principles, etc. For more information, please feel free to contact us