API powder packaging in drug solid form research
In the early stages of new drug development, a comprehensive evaluation of compound properties is required. The diverse crystal forms of API active drug molecules and the screening of polymorphic forms are labor-intensive and inefficient. The study selected three types of API powders: carbamazepine, 4-acetaminophenol, and vanillin, and used ChemPlus ® Desktop solid sampler is used to test different target sample quantities. The results showed that the standard deviation of sample addition was controllable within 0.1mg, the average sample addition time was within 2 minutes, and the uniformity of parallel sample addition was good. This instrument has advantages such as high throughput, which can save labor and avoid errors, making it an important tool for high-throughput compound screening.