In the early stages of new drug development, a comprehensive evaluation of the physicochemical properties, production feasibility, stability, and other aspects of compound molecules is required. The lack of understanding of compound properties can pose significant challenges to later research and development, and there may even be the possibility of changing candidate compounds.

The study of API active drug molecules is an important part of new drug development. There are various types of solid crystal forms of API, and differences in melting point, density, crystal habit, stability, solubility, and other aspects will reflect different bioavailability. Efficient screening of potential crystal forms of compounds is an important part of new drug development.

In the process of polycrystalline screening, salt/eutectic screening, and crystallization process development, a large number of parallel experiments need to be conducted on APIs. The heavy experimental work consumes a lot of time and energy from researchers, and problems such as low efficiency, low repeatability, and human error are the main difficulties and challenges currently faced. High throughput automated solid sampling technology not only effectively solves the problem of heavy manual repetitive labor, but also ensures the repeatability and consistency of experimental results, avoiding manual experimental errors.

We selected three common API powders: carbamazepine, 4-acetaminophenol, and vanillin, and used the desktop solid sampler ChemPlus from Jingtai Technology ® Conduct sample testing. Target sample size: 5mg, 10mg, 20mg, 30mg, 50mg, 100mg, testing times: 12 times.

The test results show that for API powder samples with different gradients, the standard deviation can be controlled within 0.1mg, and the average sample addition time is within 2 minutes. The parallel addition experiments of carbamazepine, 4-acetaminophenol, and vanillin also demonstrated good homogeneity.

ChemPlus ® Desktop solid sampling device, supporting multiple solid raw materials and receiving containers, without the need for manual supervision, automatically completes repetitive and time-consuming solid weighing and sampling operations. High throughput: can accommodate various solid raw materials and receiving containers, comprehensively improving efficiency. Wide range of applications: samples do not require special processing, can cover larger particles, fluffy, and poorly flowing powders. Static electricity removal: effectively reduces static electricity effects, more accurate sample addition. Low cost: low consumable prices, cost savings. Small footprint: small machine size, wide desktop compatibility: compatible with multiple laboratory commonly used sizes. Small bottle data tracking: barcode or QR code sample management, supports audit tracking, simple interactive software: visual operation software, easy to use

Utilizing the high-throughput automated desktop solid sampler ChemPlus ® Adding samples to API powder can not only save a lot of manual operation time, but also avoid manual operation errors, ensuring the uniformity and consistency of experimental results. thus it can be seen, ChemPlus ® It is an important tool in high-throughput compound screening research.