SW626 cells

NegotiableUpdate on 05/06

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Nature of the Manufacturer: Producers

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Overview

SW626 cells originate from ovarian adenocarcinoma in a 64 year old black female, exhibiting epithelioid and adherent growth, high expression of ovarian cancer markers, and invasive properties. Commonly used in ovarian cancer research and drug development to help overcome challenges.

Product Details

SW626 cellsA powerful tool for ovarian cancer research

SW626 cellsIn the field of life science research, especially ovarian cancer research, it plays an important role and provides a key research model for tackling this serious disease that threatens women's health.

SW626 cells were derived from ovarian adenocarcinoma tissue of a 64 year old black female and collected and preserved by the American Type Culture Collection (ATCC). Due to its direct extraction from tumor tissue of ovarian cancer patients, it retains many typical characteristics of ovarian cancer cells and is an ideal cell line for studying the pathogenesis, development process, and treatment strategies of ovarian cancer.

In terms of morphology, SW626 cells exhibit an epithelioid morphology, with polygonal or irregular shapes when growing adherent to the cell wall. The cells are tightly connected to each other, forming a relatively regular cell monolayer. During the cell culture process, SW626 cells exhibit strong proliferative ability. RPMI 1640 medium containing 10% fetal bovine serum is usually used, and cells can grow and pass stably in a constant temperature and humidity incubator environment at 37 ℃ and 5% carbon dioxide. The doubling time is about 24 to 36 hours, providing sufficient cell sources for large-scale experiments.

From a biological perspective, SW626 cells highly express various biomarkers associated with ovarian cancer, such as CA125 and human epidermal growth factor receptor 2 (HER2). These biomarkers are of great significance in the diagnosis, disease monitoring, and targeted therapy of ovarian cancer. In addition, the cell has the ability to invade and metastasize, which can simulate the process of ovarian cancer cells breaking through the basement membrane, invading surrounding tissues, and undergoing distant metastasis in vivo. This is crucial for studying the mechanism of ovarian cancer metastasis.

In terms of scientific research applications, SW626 cells are widely used in basic research and drug development of ovarian cancer. Researchers have explored the key molecular pathways involved in the occurrence and development of ovarian cancer, such as the abnormal activation of the PI3K/AKT signaling pathway and its relationship with cell proliferation and survival, by performing gene editing and interfering with specific gene expression in SW626 cells. In drug development, SW626 cells can be used as a model to screen potential anti-cancer drugs, evaluate the inhibitory effect, cytotoxicity, and resistance mechanism of drugs on ovarian cancer cells. For example, studying the proliferation inhibition rate and induction of apoptosis of SW626 cells by a novel Hua therapy drug provides important preliminary data for the drug to enter the clinical trial stage.

With its biological characteristics and wide application value, SW626 cells have become an indispensable cell model in the field of ovarian cancer research, continuously promoting the in-depth development of ovarian cancer research and bringing hope for improving the prognosis of ovarian cancer patients.