SW620 cells

NegotiableUpdate on 05/06

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Overview

SW620 cells, nearly 3000 kinds of cells from Shanghai Beili Biological Company, are from ATCC in the United States. All cells are under strict quality control, and strive to build a bridge between authentic cells and domestic researchers in Chinese Mainland. In addition, there are more related experimental products, standard products, cell lines, experimental technology services, and other pre - and follow-up services..

Product Details

SW620 cellsAn important model for colorectal cancer research

In the field of cancer research,SW620 cellsAs a special cell line, it provides key clues for exploring the mysteries of colorectal cancer.

SW620 cells were derived from metastatic lymph nodes of colorectal adenocarcinoma in a 51 year old white male. The particularity of its origin makes it an ideal object for studying the mechanism of colorectal cancer metastasis. Compared with other cell lines, SW620 cells exhibit unique biological characteristics. It has an epithelial cell like morphology and exhibits adherent growth during the cultivation process. The cell population is mainly composed of individual small spherical cells and bipolar cells without microvilli.

From a molecular biology perspective, SW620 cells exhibit a series of significant characteristics. It can only synthesize a small amount of carcinoembryonic antigen (CEA), synthesizing only 0.15ng per 106 cells within 10 days. However, it exhibits high tumorigenicity in nude mice, indicating its ability to grow and develop tumors. In addition, the cell is capable of synthesizing transforming growth factor alpha (TGF alpha) and matrix lysin, which play critical roles in the invasion and metastasis of tumor cells. In terms of gene expression, SW620 cells express genes such as myc, K-ras, H-ras, N-ras, Myb, sis, fos, etc., but no expression of N-myc gene was detected. Of particular note is that the 273 codon of its P53 gene exhibits specific conditions that affect cell growth and regulation.

The doubling time of SW620 cells is approximately 20.4 to 37.06 hours, which provides a suitable time scale for related research. In scientific research applications, due to its origin from metastatic lesions, researchers can use SW620 cells to explore in depth the metastasis mechanism of colorectal cancer cells, including how cells break through the primary lesion, enter the bloodstream, and form new tumors in distant tissues. In the field of drug development, it also plays an important role. By testing the efficacy of various anticancer drugs on SW620 cells, the inhibitory effect, cytotoxicity, and potential resistance mechanisms of drugs on colorectal cancer cells can be evaluated, providing experimental evidence for the development of more effective colorectal cancer treatment drugs.

SW620 cells, with their unique origin and biological characteristics, occupy an indispensable position in both basic research and clinical treatment research of colorectal cancer, greatly promoting scientific progress in this field.