SW48 cells

NegotiableUpdate on 05/06

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Overview

SW48 cells are derived from colorectal adenocarcinoma in situ in a 51 year old white male, with epithelioid morphology and high expression of related biomarkers. It is widely used in colorectal cancer research and has significant implications for exploring mechanisms, developing drugs, and anti metastatic strategies.

Product Details

SW48 cellsKey cell models for colorectal cancer research

SW48 cellsAs an important tool in the field of colorectal cancer research, it provides critical support for exploring disease mechanisms and developing treatment methods.

SW48 cells were derived from in situ colorectal adenocarcinoma tissue of a 51 year old white male, collected and preserved by the American Type Culture Collection (ATCC), and provided to * researchers. This cell line retains the typical characteristics of colorectal cancer cells and has irreplaceable value for studying the occurrence, development, and related mechanisms of colorectal cancer.

From a biological perspective, SW48 cells exhibit an epithelial like morphology, with irregular polygonal shapes during adherent growth and tight intercellular connections. At the molecular level, this cell highly expresses various biomarkers associated with colorectal cancer, such as carcinoembryonic antigen (CEA), cytokeratin 19, etc. Its gene expression profile also reflects the abnormal proliferation, invasion, and metastasis characteristics of colorectal cancer cells. These features make SW48 cells an ideal model for simulating the occurrence and development of colorectal cancer in vivo.

In terms of cell culture, SW48 cells have specific requirements for culture conditions. RPMI 1640 medium containing 10% fetal bovine serum is commonly used to provide the necessary nutrients and growth factors for cell growth. The cultivation environment should be maintained in a constant temperature and humidity incubator with 37 ℃ and 5% carbon dioxide to create suitable gas and temperature conditions for cell metabolism and growth. Under appropriate culture conditions, SW48 cells grow rapidly and have strong proliferation ability, which provides the possibility for large-scale cell experiments.

SW48 cells have a wide range of applications in scientific research. In the study of tumor development mechanisms, researchers have explored the key molecular pathways involved in colorectal cancer, such as the abnormal activation of the Wnt/β - catenin signaling pathway in SW48 cells and its relationship with tumor cell proliferation and differentiation, by performing gene editing and interfering with specific gene expression in SW48 cells. In the field of drug development, SW48 cells can be used as a model to screen potential anti-cancer drugs, evaluate the inhibitory effect, cytotoxicity, and mechanism of action of drugs on colorectal cancer cells. For example, studying the proliferation inhibition rate and induction of apoptosis of SW48 cells by a novel drug provides important data for preclinical drug research. In addition, in the study of tumor metastasis, by utilizing the invasive and metastatic characteristics of SW48 cells, an in vitro metastasis model is constructed to explore the molecular mechanisms and influencing factors of colorectal cancer cell metastasis, providing a theoretical basis for the development of anti metastatic treatment strategies.

SW48 cells, with their unique biological characteristics and wide application value, have become an indispensable cell model in the field of colorectal cancer research, driving continuous progress in basic research and clinical treatment of colorectal cancer.