RAGE antagonist peptide RP-1 (APDTKTQ) active peptide segment TKTQ

RAGE antagonist peptide RP-1 (APDTKTQ) active peptide segment TKTQ

RAGEAntagonistic peptideRP-1(Serial number)Apdtktq）It's researchRAGEThe key tool of the signaling pathway. Its core active fragmentTKTQEndowing the peptide with high specificity binding ability. As a high-purity scientific research reagent, its quality parameters (purity)≥98%or≥95%Molecular weight confirmation by high-performance liquid chromatography（HPLC）Compared to mass spectrometry（MS）Perform strict characterization. This article focuses on the quality control process, structural characteristics, and application background of the reagent in instrument analysis.

1、 Product Introduction and Quality Control Parameters

This product is chemically synthesizedRAGEAntagonistic peptideRP-1The complete amino acid sequence isAla-Pro-Asp-Thr-Lys-Thr-Gln (APDTKTQ)The theoretical molecular weight is745.8 DaTo ensure its reliability as a research reagent, we have established a standardized quality control system:

1.1 Purity Analysis

Adopting reverse phase high-performance liquid chromatography method（RP-HPLC）Perform purity identification. Each batch of products is providedHPLCChromatogram, percentage of main peak area≥98%or≥95%This indicates that the product has chemical homogeneity. Active peptide segmentTKTQThe integrity is achieved throughHPLCThe consistency of retention time has been verified.

1.2 Structural confirmation

Using electrospray ionization mass spectrometry（ESI-MS）Perform molecular weight identification. measured[M+H]+The deviation between the ion peak and the theoretical molecular weight is within the allowable range (usually≤0.05%）Ensure that the target peptide sequence is confirmedApdtktqThe correct synthesis, especially the key active sitesTKTQIntegrity.

1.3 Product documentation

Provide detailed certificates of conformity along with the goods（COA）, including all quality control data, synthesis reports, and storage recommendations.COADocuments are an important guarantee for product traceability and reproducibility of experimental results.

RAGE antagonist peptide RP-1 (APDTKTQ) active peptide segment TKTQ

2、 Application background

This research reagent is commonly used for research purposesRAGEReceptors and their ligands (such asHMGB1TheS100The interaction mechanism between proteins. In drug screening experiments, researchers utilizeRAGEAntagonistic peptideRP-1As a positive control, surface plasmon resonance was used（SPR）Or fluorescence polarization（FP）Technology, evaluating candidate compounds forRAGEThe affinity. Its high purity ensures the accuracy and repeatability of the screening data. Active peptide segmentTKTQThe binding specificity also provides important references for the study of structure-activity relationships.

3、 Related product recommendations

• RAGECyclic peptide analogues of antagonistic peptides（Cyclic RP-1 Analog）

• DSPE-PEG3400-RP-1(Long chain)PEGPhospholipid conjugated peptides)

• Rhodamine BmarkedRP-1(Rhodamine marker)

• Double fluorescence labelingRP-1（FITC/BiotinDual function mark)

• PEGylationRAGEAntagonistic peptide（PEGylated RP-1The molecular weight can be customized

4、 Company Profile

Our company is committed to providing high-quality chemical reagents and biomolecules for the field of life sciences. The product range covers peptides, proteins, antibodiesPEGDerivatives and various modifying reagents. We have a professional quality control team, and all products have undergoneHPLCTheMSWaiting for strict testing and accompanied byCOAWe promise to deliver inventory products quickly and provide customized synthesis and technical consulting services to major universities and research institutes across the country. All products are for scientific research use only and are strictly prohibited from clinical use or direct contact with the human body. We have won the trust of our customers with fast after-sales response and reliable product quality.