(COOH) 7-8ARM PEG Mal heterodox eight arm polyethylene glycol

(COOH) 7-8ARM PEG Mal heterodox eight arm polyethylene glycol

Eight arms-Polyethylene glycol carboxyl (7)/maleimide (1)

8arm PEG，1arm-Maleimide，7arm-Acetic Acid

[English nickname 1]8ARM-PEG-MAL（1) /COOH（7）

[English nickname 2](COOH)7-8ARM-PEG-Mal

[Structure]

[Brand]Carbon Water Technology（Tanshtech）

PurityOver 95%

[Save]-20℃

Molecular weightPEG:2K,5K,10K,20k

[Other molecular weights]Contact Customer Service

supplementThe ratio of COOH and MAL can be customized at any ratio

(COOH) 7-8ARM PEG Mal heterodox eight arm polyethylene glycol

8-ARM-PEG-MAL (1)/COOH (7) is composed of an eight armed star shaped PEG skeleton, with Maleimide active group at the end of one arm and carboxyl group (- COOH) at the end of seven arms, forming an orthogonal end group layout with thiol reaction entrance and multiple amine coupling sites.

characteristic

Highly asymmetric arm structure:

The core is an eight armed structurePEG molecule, but with carboxyl groups at the end of 7 arms and maleimide at the end of 1 arm. This asymmetry is the foundation of its multifunctionality.

Double reactivity/orthogonal reactivity:

Maleimide end:inUnder pH 6.5-7.5 conditions, a rapid, efficient, and specific Michael addition reaction can occur with thiol groups to form stable thioether bonds.

Carboxyl terminal：Can react with amino groups to form amide bonds.

Excellent biocompatibility:

PEG backbone has excellent biocompatibility, anti protein non-specific adsorption, and "stealth" properties, which can reduce immune recognition and prolong circulation time in the body.

Good water solubility:

PEG is highly hydrophilic, making the molecule and most of its coupling products easily soluble in aqueous reaction systems.

Space resistance and arm flexibility:

The multi arm structure provides multiple connection points, whileThe flexibility of PEG chains allows for the movement and orientation adjustment of the connected molecules.

effect

Build multi-functional cross-linked network/hydrogel:

It is possible to use the maleimide end to react with molecules containing thiol groups (such as peptides, proteins), while the carboxyl end can react with molecules containing amino groups (such as another peptide, protein, or amine modified material) to form complex, functionalized three-dimensional network structures.

Targeted coupling of proteins/antibodies:

It can be designed to specifically connect the maleimide end to the reduction site (hinge thiol group) of the antibody, achieving directional coupling while retaining theSeven carboxyl arms are used to connect other molecules (such as fluorescent dyes, drugs, or other proteins).

Preparation of "star shaped" or "tree shaped" conjugates:

It can serve as a core by placing a functional molecule (via maleimide) at the center and connecting multiple other molecules (via carboxyl groups) around it, creating complex macromolecules with specific structures and functions.

Surface functionalization:

It is possible to fix one end (such as maleimide) on the surface of a substrate with thiol groups, allowing multiple carboxyl arms to extend outward, thereby creating a high-density active surface that can be further modified.

Drug delivery system:

As a drug carrier, the maleimide end can be used to connect targeted ligands, while multiple carboxyl arms can be used to load drug molecules and construct multifunctional targeted nanomedicines.

Diagnostic reagent:

In immunoassay, it can be used to simultaneously connect signal molecules (such as enzymes or fluorescent groups) and capture molecules to construct sensitive detection probes.

Tanshtech series products

Eight arm polyethylene glycol, seven arm amino, one arm ice flosserine 8arm PEG，1arm-Norbornene，7arm-Amine

Eight arm polyethylene glycol, seven arm amino, one arm carboxyl 8arm PEG，1arm-Acetic Acid，7arm-Amine

Eight arm polyethylene glycol, seven arm maleimide, and one arm biotin 8arm PEG，1arm-Biotin，7arm-Maleimide

Eight arm polyethylene glycol, seven arm carboxyl, one arm alkynyl 8arm PEG，1arm-Alkyne，7arm-Acetic Acid

Eight arm polyethylene glycol, seven arm azide, and one arm acrylic ester 8arm PEG，1arm-Acrylate，7arm-Azide

Eight arm polyethylene glycol, seven arm acrylamide, and one arm biotin 8arm PEG，1arm-Biotin，7arm-Acrylamide