Powder cation resin, powder anion resin, chromatographic separation resin

Our company mainly produces ion exchange resins in five series and over fifty models. Based on the technical quality of ion exchange resins from Tianjin Nanda Resin Technology Co., Ltd., we produce macroporous strong acid cation exchange resins: 001x7, 001x1, 001x4, 001x14, 001x7x7, D72, D61, D001-CC, D81, MKC-9 dry hydrogen resins; Various gel type and macroporous weak acid cation resins: D113, D152, D151, 110; Various gel type and macroporous strong base anion exchange resins: 201x4, 201x7, 205x7, D290, D296, D261, 280, D284; Various macroporous weak base anion exchange resins: D301, D301, GD370, D371, D392, D380, D382; Chelating ion exchange resin: D401, D403, D418; Various macroporous adsorption resins: D3520、D4006、D4020、H103、H107、H1020、X-5、AB-8、NKA、NKA-2、NKA-9、S-8 Waiting for other large holes to suck1. Product Introduction
1.1 Specification standards:
Product Name: Macroporous Adsorption Resin
Brand (Type) Number: D-101
Structure: Styrene type copolymer PDVB
Polarity: Non polarity
1.2 Technical indicators:
Particle size range: 0.31.25 (mm)>90%
Moisture content: 6575%
Wet true density: 1.10-1.18 (g/ml)
Wet visual density: 0.60.7 (g/ml)
Apparent density: 0.280.34 (g/ml)
Skeleton density: 0.84-1.10 (g/ml)
Specific surface area: 550600m ²/g
Average pore size: 90100A º
Porosity: 70%
1.3 Main purpose:
This product is widely used for extracting, isolating, and purifying various saponin active substances from natural plants, such as ginseng
Saponins, Panax notoginseng saponins, anthocyanins, etc.
2. User Manual
2.1 Introduction to resin properties:
This resin is an artificially synthesized polymer macroporous adsorbent, characterized by the ability to produce
Adsorption and desorption processes are used to achieve the separation and purification of substances. It is related to activated carbon, alumina, and silicon
The function of natural adsorbents such as glue is similar, but different. Its characteristic is that it is easy to regenerate and can be repeatedly used
Use it.
This resin is an adsorbent with divinylbenzene as the skeleton structure, and the benzene ring connected to the main chain is a
A plane with uniform electron distribution, suitable for molecules with similar properties and various cyclic aromatic compounds
Strong adsorption capacity, which increases with the enhanced lipophilicity of the adsorbed molecules. It has been produced naturally in recent years
In the separation of substances, especially for water-soluble compounds, purification shows that their single fruit is therefore in
The separation and purification process of herbal extracts plays an extremely important role.
This product has stable physicochemical properties and is insoluble in acids, bases, and organic solvents. It does not melt when heated and can withstand temperatures up to 150 degrees Celsius
The following uses. Good selection of organic compounds, unaffected by inorganic salts; Easy to regenerate, optional regenerant
Use water, dilute acid, dilute alkali or low boiling point organic solutions such as methanol, ethanol, acetone, etc. The appearance color is light white,
It brings convenience to processing operations, is easy to observe, and has a long service life.
2.2 Precautions for use and possible handling methods for abnormal situations:
a. The entire use process should avoid mechanical impurities from entering the resin, and complex raw materials must undergo strict testing
Filter.
b. The resin has a moisture content of about 70% and needs to be stored at room temperature to prevent the sphere from cracking due to freezing caused by moisture in winter,
Destruction intensity.
c. The resin should be stored in a wet state. If some spherical particles are exposed to air and lose water, they can be impregnated with ethanol or acetone
Process and then use.
d. Interrupted use, long downtime, resin must be washed clean and stored, and water should be changed regularly to prevent bacteria
Organic pollution. It can also be soaked in saturated saline or ethanol solution for long-term storage.
2.3 Resin usage method:
a. Pre treatment method for resin: Soak the resin column in ethanol that is 10 centimeters higher than the resin layer for 4 hours
At that time, release the soaking solution until the washing solution is diluted with water in the test tube and no longer turbid, and the washing solution is scanned with ultraviolet spectroscopy
Until no absorption peak can be detected. Wash with water until the ethanol content is less than 1%, then it can be used.
Qualification evaluation criteria for resin pretreatment:
(A) Wash the resin column with three times the amount of ethanol, and the eluent should not be turbid when an equal amount of water is added;
(B) The eluent cannot detect any absorption peak by scanning with ultraviolet spectroscopy;
b. After resin column installation, the reverse flow injection method can be used to exhaust the gas in the resin, otherwise it will be affected during use
Gas resistance affects adsorption. At the same time, maintain the liquid level during use to prevent air from entering.
c. Suggested operating conditions:
Step Flow Rate Flow Rate Remarks
Wet method of filling and column installation, with resin filling height less than 3 meters
Reverse flow column washing to remove small particles and broken resin
Pre treatment of 15BV/h 3BV with ethanol, acetone, etc
Wash with water to remove 15BV/h 3BV. If necessary, use a buffer solution based on the pH value of the adsorbent
Adsorption of 14BV/h should be below the adsorption capacity based on the adsorption capacity, PH=58， Temperature<50
Adding salt to the drug solution on the column is beneficial for increasing the adsorption capacity
Wash with 23BV/h 0.5-1BV to remove impurities adhered to the resin
Desorption of 0.53BV/h 2-3BV ethanol, acetone, and other (aqueous) solutions at a temperature of
Raising is beneficial for desorption
Regeneration of 0.53BV/h 3-4 BV using solvents such as ethanol, acetone, and alkaline ethanol multiple times
After washing with 2-3 BV/h of water and regenerating with 3-4 BV alkali, add acid for neutralization
Note: The specific operation should be adjusted according to the process conditions
d. Method for strengthening and regenerating resin:
After several cycles of use, the adsorption capacity of the resin decreases, and it can be treated once with an appropriate amount of 5% NaOH solution.
When the resin is severely contaminated and its adsorption capacity decreases significantly, it is necessary to strengthen regeneration. The method is to add more than
Soak the 10cm resin layer in a 2% -3% hydrochloric acid solution for 24 hours, then use a salt solution three times the volume of the resin
Pass the acid solution through the column and wash it with clean water until it is close to neutral; Soak in 5% * solution for 2-4 hours,
Using the same method as above, pass a solution of the same concentration that is three times the volume of the resin through the column, and then rinse with clean water until
The pH value is neutral, then wash the column with 2-3 times the volume of resin in ethanol, and then rinse the ethanol with pure water before adding it
Enter into use. It is possible to add some new resin to supplement the regeneration loss or apply new and old resins.
3. Reference value for effective service life of resin
The resin has stable performance and will not fail if stored properly. It can still be used after several years of storage. effective use
The date is mainly determined by the actual application process, and industrial production changes every few months to several years, with significant differences,
Generally, when the adsorption capacity decreases by more than 30% after strengthening regeneration, consider replacing the resin