NatureThink glial cell hemodynamic stimulation experimental apparatus

Product Introduction

Astrocytes are a widely distributed and largest type of glial cell in the brain, with most of their cell membrane surfaces in close contact with neurons. In the study of mechanical transduction that converts mechanical force into cellular signals, it has been found that membrane receptors can convert external forces into cellular changes through signal transduction. These mechanical sensors stimulate various cellular responses, from cell proliferation to contraction and remodeling of the cytoskeleton. Astrocytes under fluid conditions react much faster than cells under static conditions. Astrocytes are activated by shear forces, which can cause faster remodeling of the cytoskeleton in response. Helps with the migration of astrocytes. Further understanding the effect of shear force on the activity of astrocytes may provide new research ideas for fields such as traumatic brain injury and central nervous system repair.

NatureThink glial cell hemodynamic stimulation experimental apparatusUsed for simulating physiological and non physiological shear stress environments in vitro, studying the phagocytic response of astrocytes under shear stress, or exploring the migration of astrocytes under shear stress. This system is widely used in fields related to cardiovascular and cerebrovascular diseases, tumors, and orthopedics. Experiments can be conducted on the stimulation of cells by shear forces under physiological and non physiological conditions, the stimulating effect of drugs on cells under shear forces, and the comparison of the effects of constant and oscillatory currents on cells.

NatureThink glial cell hemodynamic stimulation experimental apparatusBy controlling the pump system through a computer system, important parameters such as flow rate, shear force, and time can be set independently; The fluid device can be placed in the incubator for use or used separately; Widely applicable and suitable for interdisciplinary fusion experimental research.

Parameter Description

• Cultivation area: sufficient to extract protein of 64 square centimeters;

• Fluid shear force stimulation range: 0-50 dyne/cm ²;

• Fluid shear force modes: steady flow, pulsating flow, oscillatory flow;

• Pre set different fluid shear stress stimuli in sequence in the same experiment.

Product Advantages

• Widely applicable and suitable for long-term cell culture of cells;

• Multiple shear force stimulation modes;

• The ratio of cultivation area to culture medium is small;

• Four channel culture: Each channel can be used for different cell cultures;

• User defined time, fluid shear force, and direction, etc;

• Load physiological/non physiological blood flow shear stress;

• Long term use, closer to physiological state.

Possible application research:

Experimental study on the effect of fluid shear force on cell stimulation in mechanically sensitive ion channels.

Simulate experiments on inducing differentiation of bone marrow mesenchymal stem cells into different cells under different shear stress stimuli.

Experimental study on the effect of shear stress stimulation in simulating interstitial flow on osteoclast migration.

Experimental study on the interaction between drugs, cells, and tissues under simulated blood flow shear stress.

The relationship between circulating tumor cells stimulated by simulated blood flow shear force and the occurrence and development of breast cancer.

Simulate the effects of blood flow shear force on the proliferation, invasion, migration, drug sensitivity, and survival of circulating tumor cells in the blood.

Experimental simulation of the effect of blood flow shear force stimulation on the morphology of cancer cells.

Experimental study on the effect of simulated blood flow shear stress stimulation on tumor cell metastasis.

Simulating the phagocytic response of astrocytes under blood flow shear stress state.

Simulate the effect of blood flow shear stress stimulation on endothelial function.

Simulate the effect of blood flow shear stress stimulation on inflammatory response.

Simulate the effect of blood flow shear stress stimulation on the function of the glycocalyx barrier.

Simulate the morphological changes of cells under the stimulation of blood flow shear force.

Simulate the effect of fluid shear force on bone remodeling during orthodontic procedures.

Study on the mechanism of simulated blood flow shear stress stimulation and venous thrombosis formation.

Simulate the effect of blood flow shear stress stimulation on the proliferation and migration of ocular membrane cells.

The effect of simulated blood flow shear force on the cytoskeleton of cochlear vascular endothelial cells.

NaturethinkWe are one of the earliest domestic enterprises engaged in the research and sales of biomimetic cell culture instruments. Years of technological accumulation have enabled us to have independent research and development capabilities and core technologies in the field of human biomimetic environment cultivation; We provide users with improvement, design, and research and development services for instruments and equipment.

At the same time, our company also provides various specifications of parallel plate flow chambers, cell fluid mechanical stress loading devices, cell pressure stimulation devices, cell tensile strain systems, cell mechanical stimulation systems, cell tensile stimulation systems, cell comprehensive stress experimental systems, blood circulation simulation culture systems, cell tissue construction culture systems, 3D printers, cell co culture devices, cell mechanical loading devices, organ in vitro culture devices and other scientific research equipment.

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