NatureThink Cell Venous Fluid Shear Stimulation Culture Instrument

Product Introduction

Venous thrombosis is a serious life-threatening disease, including deep vein thrombosis and pulmonary thromboembolism. Venous thrombosis is related to vascular wall shear force, blood flow velocity, and blood viscosity. Endothelial cells can sense wall shear forces, and high or low shear forces can have adverse effects on blood vessels. Higher wall shear force can cause endothelial cell damage, while lower shear force can lead to thrombosis.

The venous valve is a structure that exists within the veins, and its shape is mainly a crescent shaped double valve. In a healthy state, the venous return volume must be equal to the cardiac output volume. The main function of venous valves is to maintain blood reflux in the veins and play an important role in blood circulation. For example, when muscles contract, blood in veins compresses and valves open; When muscles expand, the valves close, preventing blood from flowing back.

NatureThink Cell Venous Fluid Shear Stimulation Culture InstrumentThis system is used to simulate physiological and non physiological shear stress stimulation environments in vitro. It can simulate three fluid modes: constant current shear stress, pulse shear stress, and oscillatory shear stress. It is possible to compare the effects of steady-state flow and oscillatory flow on endothelial cell function, or the effects of steady-state flow and pulsatile flow on endothelial cell function. Experimental studies on the efficacy of endothelial cell drugs can be conducted. This product can conduct corresponding experimental research according to different needs, mainly used for in vitro culture of cells, tissues, organoids, and organs. More experiments can be adjusted according to the user's own needs, thus simulating the real in vivo environment.

NatureThink Cell Venous Fluid Shear Stimulation Culture InstrumentYou can set important parameters such as flow rate, shear force, and time by yourself; The fluid device can be placed in the incubator for use or used separately; Widely applicable and suitable for interdisciplinary fusion experimental research.

Parameter Description

• Cultivation area: 64 square centimeters;

• Reusable: The part of the instrument in contact with the culture medium can be sterilized under high temperature and pressure;

• Fluid shear force modes: constant blood flow, pulsed blood flow, oscillatory blood flow;

• Four channel culture: Each channel can be used for different cell cultures;

• User defined time, fluid shear force, and direction, etc.

  
  

Product Advantages

• Used for adherent cells;

• Long term cell culture;

• Multiple shear force stimulation modes;

• The ratio of cultivation area to culture medium is small;

• Widely applicable and suitable for long-term cultivation of bone cells;

• The cell culture area is large, meeting the demand for protein extraction;

• The contact area of the culture medium can be sterilized and disinfected under high temperature and pressure.

Possible application research:

Experimental study on the effect of fluid shear force on cell stimulation in mechanically sensitive ion channels.

Simulate experiments on inducing differentiation of bone marrow mesenchymal stem cells into different cells under different shear stress stimuli.

Experimental study on the effect of shear stress stimulation in simulating interstitial flow on osteoclast migration.

Experimental study on the interaction between drugs, cells, and tissues under simulated blood flow shear stress.

The relationship between circulating tumor cells stimulated by simulated blood flow shear force and the occurrence and development of breast cancer.

Simulate the effect of blood flow shear force on the proliferation, invasion, migration, and survival of circulating tumor cells in the blood.

Experimental simulation of the effect of blood flow shear force stimulation on the morphology of cancer cells.

Experimental study on the effect of simulated blood flow shear stress stimulation on the migration of liver cancer cells.

Experimental study on the effect of simulated blood flow shear stress stimulation on tumor cell metastasis.

Experimental study on epithelial mesenchymal transition and ovarian cancer cell metastasis under simulated blood flow shear stress in ovarian cancer.

Simulating the phagocytic response of astrocytes under blood flow shear stress state.

Simulate the effect of blood flow shear stress stimulation on endothelial function.

Simulate the effect of blood flow shear stress stimulation on inflammatory response.

Simulate the effect of blood flow shear stress stimulation on the function of the glycocalyx barrier.

Simulate the morphological changes of cells under the stimulation of blood flow shear force.

Simulate the effect of shear stress on bone remodeling during orthodontic procedures.

Study on the mechanism of simulated blood flow shear stress stimulation and venous thrombosis formation.

Simulate the effect of blood flow shear stress stimulation on the proliferation and migration of ocular membrane cells.

NaturethinkWe are one of the earliest domestic enterprises engaged in the research and sales of biomimetic cell culture instruments. Years of technological accumulation have enabled us to have independent research and development capabilities and core technologies in the field of human biomimetic environment cultivation; We provide users with improvement, design, and research and development services for instruments and equipment.

At the same time, our company also provides various specifications of in vitro biomimetic mechanical loading systems, cell fluid stimulation culture instruments, tensile strain loading devices, organ in vitro culture devices, biomechanical stimulation devices, biological 3D printers, dampers, vascular tissue simulators, arterial and venous in vitro loading devices, organ in vitro culture instruments and other scientific research equipment.

We promise that all products sold are independently developed and do not infringe on intellectual property rights. Users can use them with confidence

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