NK Atherosclerosis Fluid Shear Force Cell Culture Instrument

Product Introduction

The local hemodynamic environment of atherosclerosis plays a very important role in the process of atherosclerosis. The branches and bends of arteries have low and reciprocating shear stress, which will disturb and up regulate the inflammatory molecules in vascular endothelial cells, thus inducing the adhesion of circulating monocytes and invading the artery wall, followed by the differentiation and migration of smooth muscle cells to the endothelium, starting the occurrence of atherosclerosis. In contrast, laminar flow with unidirectional shear force in the straight part of the artery has anti-inflammatory and atherosclerotic protective effects on the vascular system. Therefore, in the process of studying atherosclerosis, more and more researchers will pay attention to the magnitude of blood flow shear force.

NK Atherosclerosis Fluid Shear Force Cell Culture InstrumentUsed for simulating physiological and non physiological shear stress stimulation environments in vitro. The system has three fluid modes: constant current shear stress, pulse shear stress, and oscillation shear stress. It is possible to compare the effects of steady-state flow and oscillatory flow on endothelial cell function, or the effects of steady-state flow and pulsatile flow on endothelial cell function. Experimental studies on the efficacy of endothelial cell drugs can be conducted.Corresponding experimental research can be conducted according to different needs, mainly applied to in vitro culture of cells, tissues, organoids, and organs. More experiments can be adjusted according to users' own needs to simulate real in vivo environments.

NK Atherosclerosis Fluid Shear Force Cell Culture InstrumentBy controlling the pump system through a computer system, important parameters such as flow rate, shear force, and time can be set independently; The fluid device can be placed in the incubator for use or used separately; Widely applicable and suitable for interdisciplinary fusion experimental research.

Product Advantages

• Used for adherent cells;

• Long term cell culture;

• Multiple shear force stimulation modes;

• The ratio of cultivation area to culture medium is small;

• Widely applicable and suitable for long-term cultivation of adherent cells;

• The cell culture area is large, meeting the demand for protein extraction;

• The contact area of the culture medium can be sterilized and disinfected under high temperature and pressure;

Possible application research:

Experimental study on the effect of fluid shear force on cell stimulation in mechanically sensitive ion channels.

Experimental study on the effect of shear stress stimulation in simulating interstitial flow on osteoclast migration.

Experimental study on the interaction between drugs, cells, and tissues under simulated blood flow shear stress.

Experimental study on the effect of simulated blood flow shear stress stimulation on tumor cell metastasis

Experimental study on epithelial mesenchymal transition and ovarian cancer cell metastasis under simulated blood flow shear stress in ovarian cancer

Simulating the phagocytic response of astrocytes under blood flow shear stress state.

Simulate the effect of blood flow shear stress stimulation on endothelial function.

Simulate the effect of blood flow shear stress stimulation on inflammatory response.

Simulate the effect of blood flow shear stress stimulation on the function of the glycocalyx barrier.

Simulate the morphological changes of cells under the stimulation of blood flow shear force.

Simulate the effect of fluid shear force on bone remodeling during orthodontic procedures.

Study on the mechanism of simulated blood flow shear stress stimulation and venous thrombosis formation.

Simulate the effect of blood flow shear stress stimulation on the proliferation and migration of ocular membrane cells.

The effect of simulated blood flow shear force on the cytoskeleton of cochlear vascular endothelial cells.

Research on Fluid Dynamics Factors Related to Skeletal Diseases

• Joint problems: osteoarthritis, ankylosing spondylitis, etc; The effect of shear force stimulation on cartilage matrix metabolism and chondrocyte proliferation in joint chondrocytes is crucial for the repair of joint cartilage injuries.

• Skeletal problems: osteoporosis, osteoporosis, fragility fractures, traumatic fractures, etc; Shear force is the main stress that skeletal cells can perceive, and its effect on skeletal cells and the basic structure of bones is of great significance.

• Orthodontic issues: jaw deformities; Orthodontics, etc; Mechanical force stimulates the release of extracellular matrix related factors to participate in periodontal physiological functions, ensuring sustained bone resorption activity.

NaturethinkWe are one of the earliest domestic enterprises engaged in the research and sales of biomimetic cell culture instruments. Years of technological accumulation have enabled us to have independent research and development capabilities and core technologies in the field of human biomimetic environment cultivation; At the same time, we provide users with instrument and equipment improvement, design, and research and development services.

At the same time, our company also provides various specifications of cell fluid shear stress systems, endothelial and smooth muscle cell in vitro co culture systems, biomimetic pressure culture instrument NK-P40, parallel plate flow chamber, cell tensile stress (strain) stimulation experimental system, cell positive pressure stimulation experimental room system, cell comprehensive stress experimental system, blood circulation simulation culture system, cell tissue construction culture system, 3D printer, cell co culture device, cell mechanics loading device, organ in vitro culture instrument and other scientific research equipment.

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