NatureThink Interstitial Flow Stimulation Tumor Cell Experiment Instrument

Product Introduction

Ovarian cancer is the second leading cause of gynecological cancer death in women, and is a malignant tumor of the ovary, classified as epithelial ovarian cancer. At present, significant progress has been made in the biochemical regulatory signaling pathways involved in the metastasis of epithelial ovarian cancer. Existing research has simulated the importance of fluid shear stress on tumor formation and development, including cancer-related fibroblasts, angiogenesis, and the resulting tumor vascular system. Regarding epithelial ovarian cancer, there are studies on how shear stress affects epithelial to mesenchymal transition and ovarian cancer cell metastasis.

NatureThink Interstitial Flow Stimulation Tumor Cell Experiment InstrumentUsed to simulate physiological and non physiological shear stress stimulation environments in vitro, exploring the effects of various shear forces on cancer cells during metastasis under shear stress. This system is widely used in the study of tumor related disease mechanisms such as hemangiomas, sarcomas, aneurysms, lymphangiomas, and myeloma. Experiments can be conducted on the stimulation of cancer cells by shear forces under physiological and non physiological conditions, the stimulating effect of drugs on cancer cells under shear forces, and the comparison of the effects of constant and oscillatory currents on cancer cells.

NatureThink Interstitial Flow Stimulation Tumor Cell Experiment InstrumentBy controlling the pump system through a computer system, important parameters such as flow rate, shear force, and time can be set independently; The fluid device can be placed in the incubator for use or used separately; Widely applicable and suitable for interdisciplinary fusion experimental research.

Parameter Description

• Cultivation area: 64 square centimeters;

• Reusable: The part of the instrument in contact with the culture medium can be sterilized under high temperature and pressure;

• Fluid shear force mode:Stable blood flowPulse blood flowOscillatory blood flow;

• Four channel culture: Each channel can be used for different cell cultures;

• User defined time, fluid shear force, and direction, etc.

  
  

Product Advantages

• Used for adherent cells;

• Long term cell culture;

• Multiple shear force stimulation modes;

• The ratio of cultivation area to culture medium is small;

• Widely applicable and suitable for long-term cultivation of bone cells;

• The cell culture area is large, meeting the demand for protein extraction;

• The contact area of the culture medium can be sterilized and disinfected under high temperature and pressure;

  
  

Possible application research:

1. Experimental simulation of the effect of fluid shear force on cell stimulation in mechanically sensitive ion channels.

2. Simulate experiments on inducing differentiation of bone marrow mesenchymal stem cells into different cells under different shear stress stimuli.

3. Experimental simulation of the effect of shear stress stimulation in interstitial flow on osteoclast migration.

4. Experimental simulation of drug cell tissue interactions under blood flow shear stress.

5. The relationship between circulating tumor cells stimulated by simulated blood flow shear force and the occurrence and development of breast cancer.

6. The effect of simulated blood flow shear force on the proliferation, invasion, migration, and survival of circulating tumor cells in the blood

7. Experimental study on the effect of simulating blood flow shear force on the morphology of cancer cells

8. Experimental study on the effect of simulated blood flow shear stress stimulation on the migration of liver cancer cells

9. Experimental study on the effect of simulated blood flow shear stress stimulation on tumor cell metastasis

10. Experimental study on epithelial mesenchymal transition and ovarian cancer cell metastasis under simulated blood flow shear stress in ovarian cancer

11. Simulate the phagocytic response of astrocytes under blood flow shear stress conditions.

13. Simulate the effect of blood flow shear stress stimulation on endothelial function.

14. Simulate the effect of blood flow shear stress stimulation on inflammatory response.

15. Simulate the effect of blood flow shear stress stimulation on the function of the glycocalyx barrier.

16. Simulate the morphological changes of cells under the stimulation of blood flow shear force.

17. Simulate the effect of fluid shear force on bone remodeling during orthodontic procedures.

18. Study on the mechanism of simulated blood flow shear stress stimulation and venous thrombosis formation.

19. Simulate the effect of blood flow shear stress stimulation on the proliferation and migration of ocular membrane cells.

20. Simulate the effect of blood flow shear force on the cytoskeleton of cochlear vascular endothelial cells.

Research on Fluid Dynamics Factors Related to Skeletal Diseases

• Joint problems: osteoarthritis, ankylosing spondylitis, etc; The effect of shear force stimulation on cartilage matrix metabolism and chondrocyte proliferation in joint chondrocytes is crucial for the repair of joint cartilage injuries.

• Skeletal problems: osteoporosis, osteoporosis, fragility fractures, traumatic fractures, etc; Shear force is the main stress that skeletal cells can perceive, and its effect on skeletal cells and the basic structure of bones is of great significance.

• Orthodontic issues: jaw deformities; Orthodontics, etc; Mechanical force stimulates the release of extracellular matrix related factors to participate in periodontal physiological functions, ensuring sustained bone resorption activity.

NaturethinkWe are one of the earliest domestic enterprises engaged in the research and sales of biomimetic cell culture instruments. Years of technological accumulation have enabled us to have independent research and development capabilities and core technologies in the field of human biomimetic environment cultivation; We provide users with improvement, design, and research and development services for instruments and equipment.

At the same time, our company also provides various specifications of cell fluid shear stress systems, endothelial and smooth muscle cell in vitro co culture systems, biomimetic pressure culture instrument NK-P40, parallel plate flow chamber, cell tensile stress (strain) stimulation experimental system, cell positive pressure stimulation experimental room system, cell comprehensive stress experimental system, blood circulation simulation culture system, cell tissue construction culture system, 3D printer, cell co culture device, cell mechanics loading device, organ in vitro culture instrument and other scientific research equipment.

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