NatureThink endothelial cell fluid shear stress stimulation culture instrument

Product Introduction

The pathological and physiological mechanisms of sepsis are complex and a series of comprehensive manifestations, with excessive inflammation and immune suppression intertwined. Sepsis can cause severe damage to endothelial function, including vascular dilation and contraction regulation, barrier function, inflammation, and coagulation, leading to microcirculatory pathology and organ failure. Fluid shear force is a frictional force generated by blood flow. As long as the vascular wall maintains sufficient fluid shear force circulation, inflammation and its sequelae can be reduced, and the delivery of anti infective drugs may be improved. Therefore, physiological shear forces maintain endothelial homeostasis and play a key role in regulating endothelial inflammatory responses. Non physiological shear forces can cause endothelial dysfunction. When endothelial dysfunction occurs, it can lead to an escalation of inflammation and coagulation reactions. If not corrected in a timely manner, it can result in organ dysfunction and death.

NatureThink endothelial cell fluid shear stress stimulation culture instrumentUsed for simulating physiological and non physiological shear stress stimulation environments in vitro, studying the effects of different laminar shear forces on endothelial function. This system is widely used in fields related to cardiovascular and cerebrovascular diseases, tumors, and orthopedics. Experiments can be conducted to study the pharmacological effects of drugs on endothelial cells under shear stress, and to compare the effects of constant flow and oscillatory flow on cells.

NatureThink endothelial cell fluid shear stress stimulation culture instrumentBy controlling the pump system through a computer system, important parameters such as flow rate, shear force, and time can be set independently; The fluid device can be placed in the incubator for use or used separately; Widely applicable and suitable for interdisciplinary fusion experimental research.

Parameter Description

• Cultivation area: sufficient for protein extraction64square centimetre;

• Range of fluid shear force stimulation:0-50dyne/cm²；

• Fluid shear force modes: steady flow, pulsating flow, oscillatory flow;

• Pre set different fluid shear stress stimuli in sequence in the same experiment.

Product Advantages

• Widely applicable and suitable for long-term cell culture of cells;

• Multiple shear force stimulation modes;

• The ratio of cultivation area to culture medium is small;

• Four channel culture: Each channel can be used for different cell cultures;

• User defined time, fluid shear force, direction, etc;

• Loading physiology/Non physiological blood flow shear stress;

• Long term use, closer to physiological state.

Possible application research:

Experimental study on the effect of fluid shear force on cell stimulation in mechanically sensitive ion channels.

Simulate experiments on inducing differentiation of bone marrow mesenchymal stem cells into different cells under different shear stress stimuli.

Experimental study on the interaction between drugs, cells, and tissues under simulated blood flow shear stress.

Experimental simulation of the effect of blood flow shear force stimulation on the morphology of cancer cells.

Experimental study on the effect of simulated blood flow shear stress stimulation on tumor cell metastasis.

Simulating the phagocytic response of astrocytes under blood flow shear stress state.

Simulate the effect of blood flow shear stress stimulation on endothelial function.

14. Simulate the effect of blood flow shear stress stimulation on inflammatory response.

Simulate the effect of blood flow shear stress stimulation on the function of the glycocalyx barrier.

Simulate the morphological changes of cells under the stimulation of blood flow shear force.

Simulate the effect of fluid shear force on bone remodeling during orthodontic procedures.

Study on the mechanism of simulated blood flow shear stress stimulation and venous thrombosis formation.

Simulate the effect of blood flow shear stress stimulation on the proliferation and migration of corneal cells.

The effect of simulated blood flow shear force on the cytoskeleton of cochlear vascular endothelial cells.

NaturethinkWe are one of the earliest domestic enterprises engaged in the research and sales of biomimetic cell culture instruments. Years of technological accumulation have enabled us to have independent research and development capabilities and core technologies in the field of human biomimetic environment cultivation; We provide users with improvement, design, and research and development services for instruments and equipment.

At the same time, our company also provides various specifications of cell fluid shear stress systems, endothelial and smooth muscle cell in vitro co culture systems, biomimetic pressure culture instrument NK-P40, parallel plate flow chamber, cell tensile stress (strain) stimulation experimental system, cell positive pressure stimulation experimental room system, cell comprehensive stress experimental system, blood circulation simulation culture system, cell tissue construction culture system, 3D printer, cell co culture device, cell mechanics loading device, organ in vitro culture instrument and other scientific research equipment.

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