NatureThink Osteosarcoma Cell Hydrodynamics Cell Culture Instrument

Product Introduction

Osteosarcoma (OS), as a primary and highly malignant bone tumor, is a hereditary malignant bone tumor. The occurrence and development of osteosarcoma in biology are related to many factors. Mechanical sensitive ion channels (Piezo1, Piezo2, etc.) play a crucial role in the mechanical signal transduction of osteosarcoma cells, and shear force, as a physiological activator of ion channels, can regulate the expression of osteosarcoma cells by increasing the number of mechanical sensitive ion channels, thereby promoting apoptosis of osteosarcoma cells. Shear force, as a common mechanical force in skeletal tissue, is not only associated with apoptosis of osteosarcoma cells, but also promotes the expression and apoptosis of osteoblasts, oral squamous cells, and cancerous alveolar basement membrane epithelial cells.

NatureThink Osteosarcoma Cell Hydrodynamics Cell Culture InstrumentThis system is used to simulate physiological and non physiological shear stress stimulation environments in vitro. It is widely used in the study of hemodynamics in hollow organs such as lungs, blood vessels, bladder, stomach, etc. It can conduct experiments on the stimulation effect of drugs on osteosarcoma cells under shear stress, compare the effects of constant flow and oscillatory flow on osteosarcoma cells, and further study the mechanical sensitivity mechanism in osteosarcoma, which may provide more choices for individualized diagnosis and treatment of osteosarcoma.NatureThink Osteosarcoma Cell Hydrodynamics Cell Culture InstrumentBy controlling the pump system through a computer system, important parameters such as flow rate, shear force, and time can be set independently; The fluid device can be placed in the incubator for use or used separately; Widely applicable and suitable for interdisciplinary fusion experimental research.

Parameter description:

• Cultivation area: 64 square centimeters.

• Reusable: The part of the instrument in contact with the culture medium can be sterilized under high temperature and pressure.

• Fluid shear force modes: constant blood flow, pulsed blood flow, oscillatory blood flow.

• Four channel culture: Each channel can be used for different cell cultures.

• User defined time, fluid shear force, and direction, etc.

  
  

Product advantages:

• Used for adherent cells;

• Long term cell culture;

• Multiple shear force stimulation modes;

• The ratio of cultivation area to culture medium is small;

• Widely applicable and suitable for long-term cultivation of adherent cells;

• The cell culture area is large, meeting the demand for protein extraction;

• The contact area of the culture medium can be sterilized and disinfected under high temperature and pressure;

  
  

NaturethinkWe are one of the earliest domestic enterprises engaged in the research and sales of biomimetic cell culture instruments. Years of technological accumulation have enabled us to have independent research and development capabilities and core technologies in the field of human biomimetic environment cultivation; At the same time, we provide users with instrument and equipment improvement, design, and research and development services.

We promise that all products sold are independently developed and do not infringe on intellectual property rights. Users can use them with confidence

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