Nano particle size and potential analyzer

NS-90ZNano particle size and potential analyzerIt is a new product launched by Zhuhai Ouaike Instrument Co., Ltd. after successfully introducing and absorbing Malvern Panalytical nanoparticle characterization technology, and further adding zeta potential testing function on the basis of NS-90 nanoparticle analyzer. NS-90Z has * particle size and potential analysis capabilities, which can meet the testing needs of particle size and surface potential for a wide range of nanomaterials, formulation development, and production users. This instrument uses electrophoretic light scattering technology to measure zeta potential, dynamic light scattering technology to measure particle and molecular particle size, and static light scattering technology to determine the molecular weight of proteins and polymers. NS-90Z integrates Malvern Panaco M3-PALS phase analysis and detection technology, and widely uses high-quality optoelectronic components from a global supply chain, such as imported avalanche photodiode (APD) detectors and He Ne gas lasers. In addition, precise internal temperature control technology, closed fiber optic paths, and advanced software algorithms ensure high repeatability, accuracy, and sensitivity of data, allowing this model of instrument to analyze samples with a wide range of particle sizes, concentrations, and potentials. NS-90Z supports both SOP standard operations and intelligent evaluation of measurement data, making it convenient for users to use.

Working Principle:

NS-90ZNano particle size and potential analyzerThree technologies are integrated into a compact device instrument:

Dynamic light scattering technology:

The NS-90Z mainly uses 90 degree angle Dynamic Light Scattering/DLS technology to measure particle size and molecular size. Dynamic light scattering technology is also known as Photon Correlation Spectroscopy/PCS technology. This technology uses a photodetector to measure the scattered light intensity fluctuation signal generated by Brownian motion of particles in the sample, and then obtains the correlation function through a digital correlator. Finally, the Stokes Einstein equation is used to calculate the particle size and distribution of the particles. The particle size measured by this technology is the hydrodynamic diameter of an equivalent hard sphere that diffuses at the same speed as the measured particle.

Static light scattering technology:

NS-90Z uses Static Light Scattering (SLS) technology to measure the molecular weight of proteins and polymers. Static light scattering is a non-invasive technique used to characterize molecules in a solution. The scattered light intensity generated by particles is proportional to the square of the weight average molecular weight and the particle concentration. Static light scattering can be used to determine the molecular weight of proteins and polymers. Similar to the working mode of dynamic light scattering, when laser irradiates particles in the sample, the particles scatter in various directions. Unlike dynamic light scattering technology, static light scattering technology measures the time averaged intensity of scattered light over a period of time. Because this time averaged light intensity cannot reflect the dynamic changes of the signal over time, it is called "static light scattering". The molecular weight unit is Da (Dalton) or g/mol.

Electrophoretic light scattering technology:

NS-90Z uses laser Doppler microelectrophoresis (Electrophoretic Light Scattering/ELS) to measure zeta potential. Molecules and particles undergo electrophoretic motion under the action of an applied electric field, and their velocity is directly related to the zeta potential. The NS-90Z used mixed mode measurement, phase analysis light scattering/M3-PALS to successfully address the impact of capillary electrophoresis on testing, and simultaneously obtained the average zeta potential and distribution curve in one testing process.

Purpose:

NS-90Z is a cost-effective nanoparticle characterization instrument, suitable for applications that require high particle size measurement sensitivity or require the same results as using a 90 ° scattering angle system. The instrument is suitable for the analysis of lotion, suspension, protein and other samples.

Typical applications:

• Colloid and lotion characterization

• Drug dispersions and lotion

• Liposomes and vesicles

Zeta potential of particles and surfaces

• Improvement in ink, toner, and pigment performance

Optimize the dosage of coagulants in water treatment to reduce water treatment costs

• Shorten the development time of stable dispersions and protein solutions

• Understand the reasons for the stability or instability of the product and improve its shelf life

• Prevent the formation of protein aggregates

Maintain stability when increasing protein concentration

Technical parameters:

【 Particle size 】

1. Measurement range: 0.3nm-5000nm (based on the sample)

2. Measurement principle: dynamic light scattering method

3. Repeatability error:<1% (NIST traceable latex standard)

4. Minimum sample volume: 20 µ L

5. Minimum sample concentration of 0.1mg/mL (based on the sample)

Molecular weight

6. Molecular weight measurement range: 342 Da -2 × 107 Da, estimated from hydrodynamic diameter (dynamic light scattering)

7. Molecular weight measurement range: 9800 Da -2 × 107 Da, calculated by Debye diagram (static light scattering)

8. Measurement principle: dynamic light scattering, static light scattering

9. Minimum sample volume: 20 µ L (3-5 sample concentrations required)

Zeta potential

10. Measurement principle: electrophoretic light scattering

11. Sensitivity: 10mg/mL 66kDa protein

12. Zeta potential range:Not limited to -500mV~+500mV

13. Maximum sample concentration: 40% w/v (based on the sample)

14. Minimum sample volume: 20 μ L

15. Maximum conductivity: 200mS/cm

16. Detection technology: M3-PALS

17. Detection angle: 90 °+13 °

18. Laser source: High stability He Ne laser, wavelength 633nm, power 4mW.

19. Laser safety: Class 1, compliant with CDRH and CE standards

20. Detector: Avalanche photodiode (APD) detector, QE>50%

21. Correlator: Sampling time 25ns – 8000s, 4000 channels, 1011 dynamic linear range

22. Condensation control method: dry air blowing*

23. Temperature control range: 0 ° -90 ° C

24. Temperature control accuracy: ± 0.1 ° C

25. Power supply: AC 90-240V, 50-60Hz

26. Power: 50W

[Weight and Size]

27. Size: 320mm × 600mm × 260mm (W × D × H)

28. Weight: 19 kg

29. Computer configuration: Intel Core 2 Duo, 4GB memory, 160GB hard drive, display resolution 1440 × 900 32-bit or higher

30. Computer interface: USB 2.0

31. Operating systems: Windows 7, Windows 10

32. Temperature range: 15 ° C-40 ° C

33. Environmental humidity: 20% -70%, no condensation

34. An external gas source is required

Performance characteristics:

Advanced Optical System Design

The NS-90Z integrates electrophoresis light scattering, dynamic light scattering, and static light scattering technologies in one instrument. Measure zeta potential using electrophoretic light scattering technology, measure particle size and molecular size using dynamic light scattering technology, and determine the molecular weight of proteins and polymers using static light scattering technology. This technology requires the stability of the entire system, and every design element must be standardized to ensure high accuracy and reproducibility.

NS-90Z adopts a closed optical path design to prevent pollution. The algorithm uses the full range Mie Theory.

Feature rich software optimizes user experience

Provide standard operating procedures (SOP) to simplify routine measurements; Automatically adjust the optimal settings for various samples; Easy to operate, no need for alignment, calibration or maintenance; Intelligent, capable of automatically assessing the quality of data reports.

High performance detector

Efficient avalanche photodiode (APD) detectors have much higher sensitivity than photomultiplier tubes (PMT). High cost but guaranteed * testing performance.

Research level digital correlators

Using high-speed digital correlators with 4000 channels and sampling times as low as 25ns.

Stable laser light source and optical path system

Using a highly stable He Ne gas laser to ensure data repeatability, with a wavelength of 633nm and a power of 4mW. The laser attenuator can be automatically adjusted within a dynamic range of 300000:1.

Accurate internal temperature control system

The independent circulating temperature control tank can be set arbitrarily within the range of 0-90 ℃, with a control accuracy of 0.1 ℃, ensuring high reproducibility.

Software functions:

1. Advanced software technology and interface are used, with simple operation.

2. Fully automatic setup and measurement: With simple training, the instrument can be set up, including sample pool position, data recording, analysis, and result display.

3. Support SOP standard operating procedures to ensure consistency and data repeatability of operations.

4. Evaluation of measurement data: The instrument software can automatically determine the quality of the data report based on the testing conditions.

5. Printing or displaying reports on screen is easy to use; With a report designer, you can customize different reports according to your needs by selecting graphics and input parameters at specific locations.

6. Sample data and results are stored in measurement files for easy comparison of data.

7. Data analysis: The data is presented in the form of graphics or tables, and the distribution algorithm is suitable for various samples including monodisperse samples, widely distributed samples, and samples with multiple patterns.

8. A media granularity database with *