NK periodontal ligament fibroblast fluid shear stress stimulation culture instrument

Product Introduction

In the correction of malocclusion, the movement of teeth is based on the remodeling and reconstruction of periodontal tissue. Periodontal ligament fibroblasts are the most important type of cell in periodontal tissue, playing a role in connecting, buffering external forces, and transmitting information. During orthodontic treatment, periodontal ligament fibroblasts are the first cells to be subjected to orthodontic forces. When mechanical forces cause fluid flow in the periodontal ligament and generate fluid shear forces, the mechanical signals are converted into biomechanical signals, leading to the differentiation and proliferation of periodontal ligament fibroblasts. By applying shear forces of different durations and sizes in vitro, the expression of proteins in periodontal ligament fibroblasts induced by mechanical forces can be studied.

NK periodontal ligament fibroblast fluid shear stress stimulation culture instrumentUsed for simulating physiological and non physiological shear stress stimulation environments in vitro, to study the effects of shear stress stimulation on the function of periodontal ligament fibroblasts, providing new research ideas for orthodontic research. Experiments on the effects of shear stress stimulation on bone formation in periodontal ligament fibroblasts can be conducted in vitro, and the effects of constant current and oscillatory current on cell function can be compared

NK periodontal ligament fibroblast fluid shear stress stimulation culture instrumentBy controlling the pump system through a computer system, important parameters such as flow rate, shear force, and time can be set independently; The fluid device can be placed in the incubator for use or used separately; Widely applicable and suitable for interdisciplinary fusion experimental research.

Parameter Description

• Cultivation area: 64 square centimeters;

• Reusable: The part of the instrument in contact with the culture medium can be sterilized under high temperature and pressure;

• Fluid shear force mode: stable blood flow, pulsed blood flow, oscillatory blood flow,

• Four channel culture: Each channel can be used for different cell cultures;

• User defined time, fluid shear force, and direction, etc.

  
  

Product Advantages

• Used for adherent cells

• Long term cell culture;

• Multiple shear force stimulation modes;

• The ratio of cultivation area to culture medium is small;

• Widely applicable and suitable for long-term cultivation of bone cells;

• The cell culture area is large. Meet the demand for protein extraction;

• The contact area of the culture medium can be sterilized and disinfected under high temperature and pressure;

Possible application research:

Experimental study on the effect of fluid shear force on cell stimulation in mechanically sensitive ion channels.

Simulate experiments on inducing differentiation of bone marrow mesenchymal stem cells into different cells under different shear stress stimuli.

Experimental study on the effect of shear stress stimulation in simulating interstitial flow on osteoclast migration.

Experimental study on the interaction between drugs, cells, and tissues under simulated blood flow shear stress.

Experimental simulation of the effect of blood flow shear force stimulation on the morphology of cancer cells.

Experimental study on the effect of simulated blood flow shear stress stimulation on the migration of liver cancer cells.

Experimental study on the effect of simulated blood flow shear stress stimulation on tumor cell metastasis.

Simulating the phagocytic response of astrocytes under blood flow shear stress state.

Simulate the effect of blood flow shear stress stimulation on endothelial function.

The influence of mechanical mechanics on bone remodeling during simulated orthodontic procedures.

Research on Fluid Dynamics Factors Related to Skeletal Diseases

• Joint problems: osteoarthritis, ankylosing spondylitis, etc; The effect of shear force stimulation on cartilage matrix metabolism and chondrocyte proliferation in joint chondrocytes is crucial for the repair of joint cartilage injuries.

• Skeletal problems: osteoporosis, osteoporosis, fragility fractures, traumatic fractures, etc; Shear force is the main stress that skeletal cells can perceive, and its effect on skeletal cells and the basic structure of bones is of great significance.

• Orthodontic issues: jaw deformities; Orthodontics, etc; Mechanical force stimulates the release of extracellular matrix related factors to participate in periodontal physiological functions, ensuring sustained bone resorption activity.

• Muscle problems: connective tissue diseases, muscle atrophy, etc; ……

NaturethinkWe are one of the earliest domestic enterprises engaged in the research and sales of biomimetic cell culture instruments. Years of technological accumulation have enabled us to have independent research and development capabilities and core technologies in the field of human biomimetic environment cultivation; We provide users with improvement, design, and research and development services for instruments and equipment.

At the same time, our company also provides various specifications of cell fluid shear stress systems, cell stretching systems, cell solid stress systems, cell force systems, fluid shear stress systems, dynamic cell co culture systems, cell comprehensive stress experimental systems, blood circulation simulation culture systems, cell tissue construction culture systems, biological 3D printers, cell co culture devices, vascular organ in vitro simulation systems, organ in vitro culture instruments and other scientific research equipment.

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