(NHS) 7-8ARM PEG Mal heterodox multi armed polyethylene glycol

(NHS) 7-8ARM PEG Mal heterodox multi armed polyethylene glycol

Key product information

Chinese name:Eight arm polyethylene glycol seven arm active lipid one arm maleimide

English name:8arm PEG，1arm-Maleimide，7arm-NHS

abbreviation : (NHS)7-8ARM-PEG-Mal

Brand: Meiluo Technology（Melopeg ）

Structure:

Purity:Over 95%

定制：The ratio between MAL and NHS can be customized at any ratio

partSub quantity: PEG2K、PEG5K、PEG10K、PEG20k， Other molecular weight consultation customer service

Precautions

Keep dry

Storage conditions

-Freezing and drying below 20 ℃

(NHS) 7-8ARM PEG Mal heterodox multi armed polyethylene glycol

application

(NHS) ₇ -8ARM-PEG Mal is a bifunctional multi armed polyethylene glycol with one Maleimide reaction arm and seven NHS active ester arms. It belongs to the amine thiol orthogonal coupling precursor and is commonly used in the construction and functionalization of biomaterials.

The function of 8-arm PEG

As the molecular backbone and multi arm connection platform, it ensures the material's hydrophilicity, flexibility, resistance to non-specific protein adsorption, and good biocompatibility. The eight arm structure provides high spatial accessibility, enabling efficient covalent or molecular crosslinking, uniform network, and stable structure.

The function of Maleimide (1 arm)

As a thiol specific reaction inlet, it can be achieved through Michael conjugate addition rapidly and selectively couples with SH (such as Cys, thiolated PEG, thiol peptides or proteins), mainly responsible for directional crosslinking or biomolecule anchoring, generating stable thioether bonds and providing controllable single thiol reaction sites.

The role of NHS (7-arm)

As a high-density amine reaction arm, with NH ₂ (such as peptide N-terminus, protein Lys, amine ligands, or functional molecules) undergoes nucleophilic acyl substitution to form amide bonds, mainly used for loading bioactive molecules or constructing functional interface/surface modification layers, providing most orthogonal modifiable sites.

Related directories:

(Nor)7-8ARM-PEG-Biotin Eight arm polyethylene glycol and seven arm de icing-Pianene one arm biotin

(NH2)7-8ARM-PEG-Biotin Eight arm polyethylene glycol, seven arm amino, one arm bio-Physical element

(NHS)7-8ARM-PEG-Mal Eight arm polyethylene glycol seven arm active lipid one arm maleimide

(COOH)7-8ARM-PEG-Mal Eight arm polyethylene glycol, seven arm carboxyl group, and one arm maleimide

(HO)7-8ARM-PEG-ACA Eight arm polyethylene glycol, seven arm hydroxy, one arm acrylamide