(COOH) 3-4ARM-PEG-MAL Heretic Four Arm Polyethylene Glycol

(COOH) 3-4ARM-PEG-MAL Heretic Four Arm Polyethylene Glycol

keyProduct Information

Chinese name:Four arm polyethylene glycol, three arm carboxyl, and one arm maleimide

English name:4arm PEG，1arm-Maleimide，3arm-Acetic Acid

Abbreviation: (COOH)3-4ARM-PEG-Maleimide

Brand: MeloPEG Technology

Structure:

Purity:Over 95%

定制：The ratio of COOH and MAL can be customized at any ratio

Molecular weight: PEG2K、PEG5K、PEG10K、PEG20k， Other molecular weight consultation customer service

Precautions

Keep dry

Storage conditions

-Freezing and drying below 20 ℃

(COOH) 3-4ARM-PEG-MAL Heretic Four Arm Polyethylene Glycol

application

(COOH) 3-4ARM-PEG-Maleimide is an asymmetric multifunctional polyethylene glycol material with a four arm PEG skeleton, carboxyl groups that can form amide bonds with amino groups on three arms, and maleimide that can specifically add to thiol groups on one arm.

Application in drug delivery

1. Constructing multifunctional nanocarriers

The three armed carboxyl group can pass throughEDC/NHS forms amide bonds with amino groups on drugs or ligands, allowing the carrier to graft hydrophobic groups, hydrophilic layers, or targeted molecules, thereby self-assembling into stable nanoparticles or micelles, achieving improved drug loading efficiency and blood circulation stability.

2. Realize drug coupling with precise single point connection

Maleimide arms and thiol drugs or thiol modified proteins/Peptides undergo highly selective addition, which can achieve "single site anchoring" of drugs, avoid heterogeneity caused by random connections of multiple sites, and greatly improve the uniformity and activity retention of coupled drugs.

3. Construction of injectable and controllable release PEG hydrogel system

The COOH end is used to react with cross-linked groups containing NH ₂, and the Mal end reacts with cross-linked compounds containing – SH, which can form three-dimensional PEG hydrogels under mild conditions. It is suitable for local administration, tissue repair, slow release drug implantation and other scenarios, and has excellent biocompatibility.

4. Achieve surface functionalization and improved targeting

three armsCOOH can be used to graft functional modules such as cell targeting ligands, glycosides, and signal peptides, while Maleimide can connect thiol stabilizers or active drugs to form a "multi-point modification+single point precise loading" structure on the surface of nanocarriers, improving targeting, cell uptake, and tissue selectivity.

5. Used for protein, peptide, and biomacromolecule drug delivery

with the help ofThe broad adaptability of COOH-NH ₂ and the high specificity of Mal-SH enable the molecule to simultaneously immobilize multifunctional groups and selectively bind to biopharmaceuticals, achieving stabilization, long cycling, and directed release of biomolecules. It is an ideal connecting skeleton for constructing controllable release and precise delivery platforms.

Related directories:

(Maleimide)3-4ARM-PEG-Biotin Four arm polyethylene glycol, three arm maleimide, and one arm biotin

(Maleimide)2-4ARM-PEG-(Biotin)2 Four arm polyethylene glycol, two arm maleimide, and two arm biotin

(Biotin)3-4ARM-PEG-Maleimide Four arm polyethylene glycol, three arm biotin, one arm maleimide

(Maleimide)3-4ARM-PEG-NHS Four arm polyethylene glycol, three arm maleimide, one arm active lipid

(Maleimide)2-4ARM-PEG-(NHS)2 Four arm polyethylene glycol, two arm maleimide, two arm active lipid

(NHS)3-4ARM-PEG-Maleimide Four arm polyethylene glycol, three arm active lipid, one arm maleimide