(Biotin) 7-8ARM-PEG-NHS heterodox multi armed polyethylene glycol

(Biotin) 7-8ARM-PEG-NHS heterodox multi armed polyethylene glycol

Key product information

Chinese name:Eight arm polyethylene glycol seven arm biotin one arm active lipid

English name:8arm PEG，1arm-NHS，7arm-Biotin

Abbreviation:(Biotin)7-8ARM-PEG-NHS

Brand: Meiluo Technology（Melopeg ）

Structure:

Purity:Over 95%

定制： Biotin and The proportion of NHS can be customized at any ratio

Molecular weight: PEG2K、PEG5K、PEG10K、PEG20k， Other molecular weight consultation customer service

Precautions

Keep dry

Storage conditions

-Freezing and drying below 20 ℃

(Biotin) 7-8ARM-PEG-NHS heterodox multi armed polyethylene glycol

application

1、 Overall composition

PEG Core (8-arm PEG Core)

Radiating outward from a central nucleus (usually a glucose or polyol) 8 symmetrical PEG chains.

Each chain has flexibility, hydrophilicity, and high biocompatibility, serving as the main body of the scaffold and connecting arm.

7 arm Biotin

among which Seven PEG arms are connected to biotin molecules at the ends.

Biotin, as a targeting ligand, can interact with avidin/Streptavidin binds strongly and is used for precise localization or capture.

1 NHS active ester (1arm NHS)

第 Eight PEG arms end with NHS (N-hydroxysuccinimide) activated ester.

As a functional reaction site, it can react with primary amines Amide coupling is used for subsequent covalent modification with proteins, nanocarriers, or biomaterials.

2、 Structural Features

1. Highly symmetrical eight arm structure

The 8-arm radiating PEG provides multi site modification capability, giving the material the characteristics of multivalence and multifunctionality.

2. 7+1 oriented functionalization

Seven arms are biological elements:Provide multivalent and biometric capabilities to enhance targeting or binding ability.

One arm is NHS esters:Retain the reactive active end for covalent connection with the target molecule.

formationThe structural layout of "multi-target+single coupling" facilitates the control of the directionality of subsequent biochemical connections.

3. PEG skeleton provides excellent solubility and biocompatibility

PEG's high hydrophilicity gives it good water solubility and low immunogenicity as a whole.

Flexible scaffolds that can be used as drugs, proteins, or probes to avoid aggregation.

4. Flexible molecular configuration and adjustable spacing

PEG arms provide appropriate chain length to ensure uniform spatial distribution of biotin and reduce mutual interference.

The NHS arm remains exposed and easily accessible to the target primary amine group, improving coupling efficiency.

5. Suitable for multifunctional livingMaterial materialsMaterial construction

Multiple biotin sites support crosslinking, immobilization, and polymerization reactions;

single The NHS site is suitable for constructing directed biological hybrid systems (such as protein labeling, nanoparticle modification, etc.).

Related directories:

(NH2)7-8ARM-PEG-N3 Eight arm polyethylene glycol, seven arm amino, one arm azide

(NHS)7-8ARM-PEG-Mal Eight arm polyethylene glycol seven arm active lipid one arm maleimide

(Biotin)7-8ARM-PEG-NHS Eight arm polyethylene glycol seven arm biotin one arm active lipid

(NH2)7-8ARM-PEG-SH Eight arm polyethylene glycol, seven arm amino, one arm thiol

(ACA)7-8ARM-PEG-Biotin Eight arm polyethylene glycol, seven arm acrylamide, and one arm biotin

(NH2)7-8ARM-PEG-Mal Eight arm polyethylene glycol, seven arm amino, one arm maleimide