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(NHS) 7-8ARM-PEG-DCOO Heterogeneous Multi arm Polyethylene Glycol
NegotiableUpdate on 05/06
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Overview
(NHS) 7-8ARM PEG DBCO heterodyne multi armed polyethylene glycol $r $nNHS ester can undergo efficient amidation reaction with primary amine groups and is widely used for covalent coupling with proteins, peptides, polypeptides, and other amino containing molecules; The DBCO group can achieve rapid and specific triazole cycloaddition reactions through strain induced copper free click chemistry (SPAAC) and azide (- N3) modification molecules. This molecule combines the multifunctional modification ability and the biocompatibility of click reaction, and is often used to construct complex multi-component biomaterial systems, such as hydrogels, biological probes, drug delivery carriers, etc.
Product Details
(NHS) 7-8ARM-PEG-DCOO Heterogeneous Multi arm Polyethylene Glycol
keyProduct Information
Chinese name:Eight arm polyethylene glycol, seven arm active lipid, one arm diphenyl cyclooctane
English name:8arm PEG，1arm-DBCO，7arm-NHS
Abbreviation:(NHS)7-8ARM-PEG-DBCO
Brand:MeloPEG Technology
Structure:
Purity:Over 95%
定制：The ratio between NHS and DBCO can be customized at any ratio
Molecular weight:PEG2K、PEG5K、PEG10K、PEG20k， Other molecular weight consultation customer service
Precautions
Keep dry
Storage conditions
-Freezing and drying below 20 ℃
(NHS) 7-8ARM-PEG-DCOO Heterogeneous Multi arm Polyethylene Glycol
application
(NHS) ₇ -8ARM-PEG-DCOO is a bifunctional polymer coupling agent based on a star shaped polyethylene glycol (8-arm PEG) skeleton. Its structure consists of seven active arms modified with N-hydroxysuccinimide ester (NHS ester) at the end and one arm terminated with diphenylcyclooctyne (DBCO) at the end. NHS esters can undergo efficient amidation reactions with primary amine groups and are widely used for covalent coupling with proteins, peptides, polypeptides, and other amino containing molecules; The DBCO group can achieve rapid and specific triazole cycloaddition reactions through strain induced copper free click chemistry (SPAAC) and azide (- N3) modification molecules. This molecule combines the multifunctional modification ability and the biocompatibility of click reaction, and is often used to construct complex multi-component biomaterial systems, such as hydrogels, biological probes, drug delivery carriers, etc.
Application Description:
Biomolecular coupling
NHS esters are used for covalent bonding with primary amine containing molecules such as proteins, antibodies, and peptides.
Copper Free Click Chemistry
The DBCO group is used for rapid and mild triazole cycloaddition with azide modified molecules, suitable for in vivo environments.
Preparation of functional hydrogel
The hydrogel with controllable network structure is constructed by cross-linking different biomacromolecules with two functional groups.
Drug delivery system
Used to couple the carrier separately with targeted molecules and functional molecules to achieve precise delivery.
Surface modification of biomaterials
Realize multifunctional surface modifications, such as cell adhesion, biosensing, or anti fouling coatings.
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