(NH2) 7-8ARM-PEG-DCOO heterodyne multi armed polyethylene glycol

(NH2) 7-8ARM-PEG-DCOO heterodyne multi armed polyethylene glycol

Key product information

Chinese name:Eight arm polyethylene glycol, seven arm amino, one arm diphenyl cyclooctylene

English name:8arm PEG，1arm-DBCO，7arm-Amine

Abbreviation:(NH2)7-8ARM-PEG-DBCO

Brand: Meiluo Technology（Melopeg ）

Structure:

Purity:Over 95%

定制：NH2and The proportion of DBCO can be customized at any ratio

Molecular weight: PEG2K、PEG5K、PEG10K、PEG20k， Other molecular weight consultation customer service

Precautions

Keep dry

Storage conditions

-Freezing and drying below 20 ℃

(NH2) 7-8ARM-PEG-DCOO heterodyne multi armed polyethylene glycol

application

(NH ₂) 7-8ARM-PEG-DCOO is an eight armed star shaped PEG, in which seven arm ends are free amino groups (- NH ₂) and one arm end is connected to DBCO (strain promoted copper free click reaction group), belonging to asymmetric multifunctional PEG molecules.

Its chemical reactivity is divided into two parts:

1. The amino group (7-arm) is the main chemical coupling site, which can react with activated carboxyl groups (such as NHS esters, EDC/NHS systems), acid anhydrides, isocyanates, etc., forming stable amide bonds or urea/carbamate bonds, suitable for multi-point connection or crosslinking.

2. DBCO (1 arm) is specifically used for copper free click reaction (SPAAC) with diazo groups (- N3), without the need for copper catalysis. The conditions are mild and the selectivity is high, generating stable triazole bonds. It belongs to the biological orthogonal reaction (does not interfere with common functional groups).

In applications, it is commonly used for a two-step function building strategy:
1) First, connect PEG to the surface of materials, drugs, or carriers using 7 amino groups to achieve fixation or cross-linking;
2) Then use DBCO-N ∝ click reaction to accurately introduce targeted molecules or probes (such as azide modified peptides, DNA, fluorescent molecules, etc.).
The advantages of this division of labor design are multiple connection points, flexible functional integration, and specific and clean reactions, which are common in drug delivery, biomaterials, and molecular probe construction.

Related directories:

(NH2)7-8ARM-PEG-BocNH Eight arm polyethylene glycol, seven arm amino, one arm tert butoxycarbonylamino

(Nor)7-8ARM-PEG-Biotin Eight arm polyethylene glycol, seven arm de icing, graphene, and one arm biotin

(NH2)7-8ARM-PEG-N3 Eight arm polyethylene glycol, seven arm amino, one arm azide

(NHS)7-8ARM-PEG-Mal Eight arm polyethylene glycol seven arm active lipid one arm maleimide

(COOH)7-8ARM-PEG-Mal Eight arm polyethylene glycol, seven arm carboxyl group, and one arm maleimide