(COOH) 7-8ARM PEG Mal heterodyne multi armed polyethylene glycol

(COOH) 7-8ARM PEG Mal heterodyne multi armed polyethylene glycol

keyProduct Information

Chinese name:Eight arm polyethylene glycol, seven arm carboxyl group, and one arm maleimide

English name:8arm PEG，1arm-Maleimide，7arm-Acetic Acid

abbreviation :(COOH)7-8ARM-PEG-Mal

Brand: Meiluo Technology（Melopeg ）

Structure:

Purity:Over 95%

定制：The ratio of MAL and COOH can be customized at any ratio

Molecular weight: PEG2K、PEG5K、PEG10K、PEG20k， Other molecular weight consultation customer service

Precautions

Keep dry

Storage conditions

-Freezing and drying below 20 ℃

(COOH) 7-8ARM PEG Mal heterodyne multi armed polyethylene glycol

application

structural characteristics

·Typical eight armed star shape（3D radial PEG topology, with 8 equally long PEG chains connected to the central core, highly symmetrical spatial conformation, and strong accessibility of arm end groups.

·End group composition1 arm Maleimide (thiol reactive arm)+7 arm carboxyl (- COOH, amine conjugated), forming an asymmetric but orthogonal synergyThe same reaction layout has the potential for separation and regulation of both structural construction and functional coupling.

Coupling chemical properties

·Carboxyl groups can be converted into carbodiimide in aqueous phase (such as...) After activation, EDC/NHS undergoes nucleophilic acyl substitution with primary amines, forming stable amide bonds.

·Maleimide rapidly forms irreversible thioether bonds with thiol groups through Michael conjugated addition in neutral/weak alkaline aqueous phase.

·The two types of reactions are orthogonal and do not interfere with each other, with high site selectivity, high conversion efficiency, and few side reactions, suitable for physiological compatibility coupling and covalent crosslinking.

Drug delivery applications

·Polymer carriers with vertex like multi sites can be used for high-density drug or ligand covalent coupling, improving drug loading and molecular engineering flexibility.

·star-shaped The PEG structure ensures the solubility and cycling stability of the aqueous phase, and is suitable for nano drug carriers (Micelle/NP surface modification) and injection into gel controlled release systems.

Typical uses include:

·Mal arm construction for core anchoring or particle crosslinking with thiol containing drugs/thiol linkers;

·Carboxyl arm linked amine drugs and targeted peptides/Small molecule ligands, cleavable controlled release linkers (enzyme/pH responsive linkers);

Establish a targeted delivery/stimulus responsive controlled release/local high-density drug delivery platform.

Related directories:

(Biotin)7-8ARM-PEG-NHS Eight arm polyethylene glycol seven arm biotin one arm active lipid

(NH2)7-8ARM-PEG-SH Eight arm polyethylene glycol, seven arm amino, one arm thiol

(NH2)7-8ARM-PEG-Nor Eight arm polyethylene glycol, seven arm amino, and one arm de icing-Pianene

(N3)7-8ARM-PEG-AC Eight arm polyethylene glycol, seven arm azide, and one arm propylene-Acid esters

(ACA)7-8ARM-PEG-Biotin Eight arm polyethylene glycol, seven arm acrylamide, and one arm bio-Physical element

(NH2)7-8ARM-PEG-Mal Eight arm polyethylene glycol, seven arm amino, one arm maleimide