Nanoscribe assists in the research and development of nanoparticle drug delivery

In long-term research on drug delivery, scholars have found that nanoparticles have become suitable carriers to overcome the limitations of conventional drug formulations and their related pharmacokinetics. With the development of innovative mixing and filtering technologies in microfluidic devices, the exploration of new fields in drug research is constantly expanding. Especially the new discovery of lipid nanoparticles carrying drugs has attracted strong interest from researchers. Liposomes have been proven to have advantages in dissolving therapeutic drugs, as they can control long-term drug release and greatly extend the drug's circulation life.

The performance of microfluidics has significant advantages for the precise preparation of lipid nanoparticles as drug carriers at extremely small sizes. In this field, a research team from Brunswick University of Technology (TU) in Germany, a customer of Nanoscribe, utilizesNanoscribe's two-photon 3D printing systemInvented a specially designed microfluidic chip. The chip includes an innovative mixer for producing monodisperse drug loaded nanoparticles and precise particle size control. This will help promote the development of new drug delivery concepts.The production of effective and cost-effective customized drugs has attracted widespread attention in the pharmaceutical industry. The characteristics of poorly soluble drugs limit their oral and parenteral administration. To solve the problem of poor solubility, lipid nanoparticles containing poorly soluble drugs will become effective candidate drugs because they provide faster dissolution rates. However, producing these lipid nanoparticles is highly challenging. The entire process includes multiple steps, such as the preparation of nanoparticles and the binding of drug carriers with nanoparticles.

The coaxial laminated mixer shown in the diagram can eliminate contact with the organic phase with channel walls, while effectively mixing the organic and aqueous phases. This mixer, which includes coaxial injection nozzles, a series of stretching and folding elements, and an inlet filter, cannot be achieved through traditional 2.5D micro nano processing, but 3D two-photon polymerization technology can be used for manufacturing. Image from Peer Erfle, TU Braunschweig

Nanoscribe, founded at Karlsruhe University of Technology, known as the "European Massachusetts Institute of Technology", is a manufacturer of high-precision 3D printing equipment for balls. It has been dedicated to promoting research in innovative fields such as mechanical metamaterials, micro/nano robots, microelectromechanical engineering, biomedical engineering, and micro/nano optics, while also providing various optimized process solutions for the university's research community.

In the production process of nanoparticles, it is important to manage the narrow particle size distribution to achieve the required range of 70 nm to 200 nm. Therefore, compared with batch mixing technology, microfluidic systems provide a more optimized solution. Microfluidics can precisely control and regulate the mixing of very small amounts of liquid, and the mixing in microfluidics can simultaneously achieve the preparation of nanoparticles. And this requires the use of more effective and complex mixing elements to regulate the properties of nanoparticles and optimize the mixing mechanism. Nowadays, scientists are utilizingNanoscribe two-photon lithography technologyProduce free-form three-dimensional microfluidic components and integrate them into complex microfluidic chips. The use of this multifunctional 3D microfabrication aims to achieve a reduction in particle size distribution.

Scientists useNanoscribe two-photon lithography technologyPerform printing. Simply put, two-photon lithography is a high-precision laser 3D printing technology based on nonlinear optical principles. The resolution of ordinary single photon based 3D laser printing technology is easily affected by optical resolution and interlayer displacement mechanical errors, resulting in low accuracy. However, two-photon lithography technology uses high-energy femtosecond laser pulses to cure photosensitive resin in a very small spatial range, thereby improving the printing resolution to an incredible hundred nanometer level accuracy. This result confirms that 3D printing based on Nanoscribe two-photon lithography technology can produce highly repetitive nanoparticles with narrow particle size distribution. These findings have significant implications for the future parallel production and manufacturing of nanoparticles.

Additive manufacturing has revolutionized the way objects are produced and manufactured. At the micro nano scale,Nanoscribe is based on two-photon polymerization technologyThe processing accuracy of additive manufacturing methods is *, which can almost meet the 3D processing of any shape object. Whether the structure is simple or complex, Nanoscribe's automated 3D maskless lithography process can achieve one-step processing and shaping of the required devices, even for the processing of complex biological organs and tissues, truly achieving what you see is what you get.

Welcome to the original literature:

Goodbye fouling: a unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles

More information about 3D two-photon maskless lithography technology and product consultation

Welcome to contact Nanoscribe China Branch - Nano 3D Technology (Shanghai) Co., Ltd

German Nanoscribe ultra-high precision two-photon micro nano 3D maskless lithography system:

Photonic Professional GT2 Two Photon Micro Nano 3D Maskless Lithography System

Quantum X Align Two Photon Nano Automatic Alignment System

Quantum X shape two-photon high-performance 3D micro nano machining system

bio X quantity Two photon high-precision 3D bioprinting system