Twin screw hot melt extruder

Twin screw hot melt extruder - equipment using melt extrusion technology. Hot melt extrusion technology was originally developed by the plastic industry and is now becoming a new type of drug delivery technology. It creatively combines processing technology with pharmacy for drug delivery research, mainly used to improve the solubility of insoluble drugs, prepare sustained-release formulations, etc. This technology can treat polymer materials above their glass transition temperature, promoting effective mixing of thermoplastic adhesives and/or polymers and active ingredients at the molecular level.

　　1、 Hot Melt Extrusion:

Mix the drug and carrier evenly;

During the extrusion process, the carrier softens and the drug melts;

By squeezing the screw, different levels of mixing between the carrier and the drug can be achieved;

Can be used to prepare solid dispersions.

Hot melt extrusion technology combines many advantages of solid dispersion technology and mechanical preparation, achieving dust-free, continuous operation, good reproducibility, and efficient production efficiency. This technology can not only promote the dissolution of insoluble active ingredients to improve their bioavailability, but also be used to delay the dissolution of water-soluble active ingredients and prepare sustained-release or enteric coated formulations; In addition, it can also be applied to the preparation of taste masking microspheres or other special shaped formulations, such as film agents, stick agents, etc. Due to the short duration of the entire extrusion process and the absence of water or organic solvents, there is no need for heating and drying, making it less prone to hydrolysis and other issues.

　　2、 Application of twin-screw hot melt extruder product: improving the solubility of insoluble drugs

Drug crystal transformation: It exists in an amorphous or molecular dispersed form in the carrier, and the dissolution process does not require overcoming lattice energy.

Increased wettability: The drug is encapsulated in a water-soluble carrier and can be fully wetted by the medium.

Solubilization effect of carriers: Carriers with amphiphilic properties have a certain solubilization ability for drugs.

Micellar solubilization effect: Amphiphilic carriers can form small particle size micelles in vivo, increasing drug dissolution.

　　3、 Application of twin-screw hot melt extruder product: Long acting formulation - implant agent

Development concept: Optimize biodegradable materials, PLGA， And based on the ratio and polymerization degree of PLA and PGA, design the process parameters for hot melt extrusion and develop long-lasting formulations.

　　4、 Advantages of twin-screw hot melt extruder products:

The device has low energy consumption, with a total power of only (0.75+1.95) kW and a conventional 220V power supply;

Lightweight design of the equipment, with a total weight of only 75Kg;

The temperature zone has 7 independent sections and can adapt to various sample situations, with a maximum temperature of 250 ℃;

Low noise, using a large reduction ratio gearbox for transmission;

Configure intelligent panel, easy to operate.