Somalogic high-throughput proteome detection technology

Future Medical Research——Somalogic high-throughput proteome detection technology

——Embark on a new era of proteomics to assist in health and disease research

The study of proteomics plays a crucial role in the fields of biology and medicine. In biology, analyzing the proteome can reveal the functions and regulatory mechanisms of proteins in important biological processes such as cellular function, signal transduction, and metabolic pathways. In the field of medicine, proteomic research can uncover potential biomarkers for early diagnosis and monitoring of disease progression, providing a foundation for personalized medicine and important targets and strategies for drug development. Through high-throughput proteomics, it is possible to systematically analyze the expression profile changes of proteins in disease states, and more quickly discover biomarkers related to disease occurrence, development, and prognosis. The SomaScan Assay technology launched by Somalogic, as a next-generation high-throughput proteomics detection platform, is driving revolutionary progress in this field.

1、 Technical advantages

1. Ultra high throughput detection:SomaScan Assay PlatformIt can detect over 7000 types of proteins (up to 11K) at once, covering about one-third of the protein types in the human body, greatly improving the efficiency and breadth of proteomic research, with a sample size of only 55 μ L.

2. Detection sensitivity: The detection sensitivity of this technology is as high as 10 ^ -13 molar concentrations, which can accurately detect extremely low concentrations of proteins, ensuring the accuracy and reliability of research data.

3. Wide dynamic range of protein detection: It can accurately detect both high abundance and low abundance proteins simultaneously, covering a dynamic range of ten orders of magnitude from micromolar concentration to micromolar concentration, providing a more comprehensive protein expression profile, and effectively solving the dilemma of mass spectrometry (MS) technology being able to measure high abundance proteins but unable to measure low concentration proteins.

4. Low error rate and excellent CV value: The median detection error of SomaScan Assay is only 5%, and its coefficient of variation (CV value) is as low as 5%, which is significantly better than traditional antibody and mass spectrometry based detection methods, improving the effectiveness of data and the accuracy of research results.

2、 Technical principles

The core principle of SomaScan Assay is based on excellent nucleic acid aptamer technology (SOMAmer Reagents). By chemically synthesizing SOMAmer reagents, target proteins can be specifically captured. SOMAmer reagent carries fluorescent groups and achieves relative quantification of proteins on the chip by detecting fluorescent signals.

1. Biomarker discovery:SomaScan technology plays an important role in the discovery of biomarkers, aiding in early disease diagnosis and monitoring.

2. Large queue research: Somalogic technology is suitable for large-scale population studies and can efficiently process large amounts of samples, providing powerful tools for epidemiological research and large-scale studies, helping to discover risk factors and biomarkers of diseases.

3. Research on disease mechanisms:This technology has been widely applied in the study of various disease mechanisms such as cardiovascular disease, kidney disease, aging, respiratory and neurological diseases, tumors, and inflammation, revealing the molecular mechanisms of many diseases.

4. Drug development:Through high-throughput proteomics detection,SomaScan Assay accelerates the identification of drug targets and drug development processes, providing strong technical support for the development of innovative drugs.

Somalogic is committed to advancing scientific research and clinical practice. ourSomaScan Assay PlatformWe have analyzed nearly 600000 samples and published nearly 1000 articles, making it an important tool for proteomics research. Choosing Somalia is choosing a pioneering future. We look forward to working together with researchers and clinical doctors to explore the mysteries of life sciences and promote revolutionary progress in health and disease research.

Somalogic high-throughput proteome detection technology