Organoid chip

Organoid chip

For traditional in vitro cell culture（2D&3D）As a result, cells are in a quiescent environment and only bear the effects of drugs when they are added, making it difficult to reproduce the complex microenvironment of blood flow and different organs, tissues, and cells in the body. Therefore, it is difficult to simulate the exchange of metabolites, hormones, immune modulators, and other chemical substances between organs; For animal models, species differences can lead to significant differences in cellular, genetic, immune, and pharmacokinetic aspects. Therefore, it is difficult to infer the true response of the human body to drug absorption using animal models. It is precisely because of the limitations of animal experiments that people need a more controllable and predictable experimental method, which has drivenOrganoid chipThe development of technology.

Therefore, developing reliable and possessingclinicalPredictive preclinical models are crucial for screening various drugs and immunotherapy methods. due toThere are different organs and tissues in the human bodyDifferent from othersThe blood flow velocity,And fluidshear forcecanSignificant impact on cellsofbehaviorIn order to better simulate the blood supply environment in the human body, ItalyReact4lifeThe company has proposed a method toclassOrgan chips andBiomimetic perfusion technologyThe combined technology can construct vascularized tissue structures under biomimetic fluid dynamics conditions, creating humanized disease models with fluid dynamics properties and clinical relevance. This system aims to partially replace animals and humans for drug testing, testing drugs in the preclinical development stagetoThe toxicity and efficacy of target organs help to screen for more effective drugs in the early stages of experimentsThe prospectCandidate drugs provide reliable references for clinical trials and help accelerate drug development.

Application fields:

Disease model construction: cancer, lung, blood-brain barrier, tumor metastasiscell migration

Tumor Immunology: Immune and Tumor Cell Interactions

Drug evaluation: toxicology, efficacy, absorption

3DOrganizational Culture: Regenerative Medicine, Tissue Engineering, Stem Cells

Product advantages:

lDynamic perfusion system: making in vitro drug testing results more clinically predictive

l3Dorganization/Patient biopsy: providing more personalized precision medicine

lMulti organ linkage: evaluating safer drugs

lHigh throughput: Faster drug testing

lEasy Sampling: Cells/The culture medium can be easily sampled from the upper and lower chambers and used for downstream molecular biology analysis

lOptical grade translucent material: can be directly observed under a microscope