Pilot freeze-drying machine

NACHT (Nacht)Pilot freeze-drying machineSimulated the technical requirements of industrial freeze-drying machines, with a compact and reasonable design, a large redundancy range, and compliance with GMP and FDA standards. The freezing capacity is 6-20kg, and WRL controller and liquid temperature control shelf are used to enable the pre freezing and freeze-drying processes to be controlled on the main machine. The process results are highly comparable to those of production machines. In addition to supporting eutectic point testing system, weighing system, online sampling system, and freeze-drying curve recording software, engineering WRL control software can also be optionally selected to directly control the freeze-drying process through graphical computer control. H2O2 sterilization and high-pressure steam sterilization can be configured, or an integrated glove box system can be used for cleanroom operations through wall penetrations. The cold trap and freeze-drying chamber are designed with 316L stainless steel to ensure the cleanliness of the chamber as much as possible, as well as good ultimate vacuum degree and vacuum leakage rate.

Pilot freeze-drying machineTechnical Specifications:

Pilot freeze-drying machineApplication of freeze-drying technology:

Freeze dried products have a sponge like appearance, no drying shrinkage, good rehydration properties, and low moisture content. After packaging, they can be stored and transported at room temperature for a long time. Because the vacuum freeze-drying method has the advantages of other drying methods, it has been favored by people and has been increasingly widely used in pharmaceuticals, biological products, and food. In addition, biological products such as serum, bacterial strains, and traditional Chinese and Western medicine are mostly bioactive substances, and vacuum freeze-drying technology also provides a good solution for preserving biological activity.

Example of process exploration:

Using freeze-drying technology as an example, explain the exploration of freeze-drying technology. Multiple factors that may affect the freeze-drying process were experimentally studied (20 units per batch). Through the study of various factors such as solution preparation, pre freezing, and temperature rise rate and form in freeze-drying, a preliminary optimized process route was obtained. This process route shortened the original freeze-drying cycle from 78 hours to 45 hours and reduced the quality deviation within the batch from 2% to 1.5%. Through multiple exploratory experiments, it was found that there are four factors that have a significant impact on the freeze-drying process: filling volume, feeding method, slow sublimation period, and high-speed sublimation period. Next, multiple exploratory experiments will be conducted on the four factors of vacuum degree, gas content, slow sublimation period, and high-speed sublimation period to investigate their synergistic effects on the freeze-drying process and obtain a further optimized freeze-drying route. Afterwards, this process will be applied to pilot experiments (300 units per batch) for further adjustment and optimization at the pilot level. Finally, the process was applied to industrial scaling up (10000 units per batch) and successfully solved problems such as long production cycles and large quality deviations within batches.