Needle permeability tester

1. Needle permeability of injection drugs

The needle permeability of injected medication is an important indicator for both intravenous and subcutaneous injections. The definition of needle penetration is that the injected medication can be smoothly removed through the syringe and needle, without sticking to the barrel wall or blocking the needle. By testing the needle permeability to demonstrate the usability of the injection, manufacturers can optimize its usability and patient comfort, while ensuring quality control and product safety.

In the past, the patency of drug injections or injectable vaccines was often evaluated by manually pushing or suctioning with a syringe. Although the manual injection method is relatively simple, due to the large individual differences in the human body, it is difficult to accurately control the force of the hand, and the measured results are difficult to form a unified standard. It is also difficult to compare the results of different units.

RTA-SYT developed by Shanghai Tengba Instrument Technology Co., LtdNeedle permeability testerIt has the characteristics of easy operation, objective data, high instrument accuracy, and good repeatability, which can avoid the errors caused by human factors during manual injection testing of needle penetration, making the test results more accurate and objective. thisNeedle permeability testerSuitable for testing the injection of medication and the needle penetration of drugs.

2Needle permeability testertest method

The needle penetration of injection drugs mainly relies on the force required by the syringe to push the solution out of the injection needle. Fix the syringe on the syringe support device, apply pressure to the syringe piston through the upper fixing device connected to the force sensing element, push the injected liquid through the syringe and needle until the solution is pushed out of the needle, and calculate the average force of the solution flowing out of the needle as the needle permeability test indicator of the solution.

The needle permeability of the test solution is easily affected by the diameter of the syringe piston, injection flow rate, needle diameter and length, as well as the viscosity of the injection solution. The viscosity of the injection is related to the needle penetration and stability of the formulation. If the viscosity is too small, particles are prone to aggregation and sedimentation, and the system tends to be unstable; If the viscosity is too high, the needle penetration is poor and injection is inconvenient.

3Needle permeability testerperformance parameters

(1) Force sensing element: using replaceable load sensing components, available in 0.5kg, 1kg, 5kg, 10kg, 20kg, 30kg load sensing components. Third party standard weights can be used for metrological verification and calibration.

(2) Sample spatial distance: 0-360mm, displacement accuracy: 0.001mm.

(3) Test speed: 0-35mm/s, speed resolution: 0.005mm/s

(4) External dedicated software: can switch between Chinese and English at any time, with optional testing modes. The testing speed, parameters, and targets can be set arbitrarily. The software has a positioning function that can locate the probe in a certain position.

(5) During the software testing process, there is a real-time display box, and the detection process data can be displayed in real time, allowing users to directly observe changes in the detection map. The test curve is located in the middle of the software, and the test indicators and parameters are located below the test curve for easy observation and analysis.

(6) The raw data is automatically saved in Excel format for easy later analysis. Multiple test curves can be stacked for comparative analysis, or a single test curve can be exported; The test results can be exported in bulk in Excel format, which is convenient and fast.