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Hangzhou Xunshu Technology Co., Ltd
Microscopic analysis, colony counting screening, and antibacterial zone measurement combined instrument
NegotiableUpdate on 05/06
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Overview
The new MF6 is a multifunctional all-in-one machine upgraded by Xunshu Technology, which helps to achieve intelligence in routine microbial experiments: microscopic cell observation and analysis, automatic colony counting and screening, antibacterial zone measurement, and potency analysis. $r $n Microscopic Digital Imaging is composed of a German Zeiss PrimoStar microscope paired with a thermoelectric cooling camera (SONY CCD chip), providing clear cell images, good color reproduction, and high sensitivity under low light conditions. The imaging of bacterial colonies and inhibition zones is carried out using a color CCD camera combined with an ultra-high resolution fixed focus lens (200 Lp/mm), resulting in vivid color images
Product Details
MF6 Microscopic Cell Analysis, Colony Counting, Screening, and Antibacterial Zone Measurement Combined Instrument
The new MF6 is a multifunctional all-in-one machine upgraded by Xunshu Technology, which helps to achieve intelligence in routine microbial experiments: microscopic cell observation and analysis, automatic colony counting and screening, antibacterial zone measurement, and potency analysis.
Microscopic digital imaging is composed of a German Zeiss PrimoStar microscope combined with a thermoelectric cooling camera (SONY CCD chip), which provides clear cell images, good color reproduction, and high sensitivity under low light conditions. The imaging of bacterial colonies and inhibition zones is carried out using a color CCD camera combined with a high-resolution fixed focus lens (200 Lp/mm), resulting in vivid colors and sharp details in the images.
The system also has data security, audit tracking, and information management functions toAnti tampering technology, intelligent reconstruction technology of testing environment testing process, watermark signature technologyAs the core, we will build a multi-level and mutually restrictive safety management and guarantee system, which meets the requirements of the State Food and Drug Administration for food and drug testing computer information systems.
Microscopic image analysis
Microscopic image acquisition
The Zeiss PrimoStar high-definition microscope is used for optical image acquisition, and the optical images are converted into high-quality digital signals through a 1.4 million pixel cold CCD. Thermoelectric cooling CCD can effectively reduce thermal noise, thereby obtaining high-resolution images, suitable for image capture in low light conditions.
cell counting
It has a large number of statistical functions, such as regional statistics, diameter classification statistics, color recognition statistics, adhesion segmentation, impurity removal, mouse click statistics, etc., which can quickly count spores and cells.
Image processing and annotation
Built in 27 image processing methods, such as adaptive enhancement, color component enhancement, and image processing
Flattening, edge sharpening, filtering, edge detection, morphological operations, etc. can significantly improve the microscopic observation effect and meet the special needs of users. Text and graphic embedding tools can provide assistance for writing scientific research papers.
Flattening, edge sharpening, filtering, edge detection, morphological operations, etc. can significantly improve the microscopic observation effect and meet the special needs of users. Text and graphic embedding tools can provide assistance for writing scientific research papers.Microscopic measurement function
Can accurately measure the diameter, angle, curvature, and circumference of cells and hyphae
Area, as well as the length of any manually drawn lines, arcs, curves, etc., and automatically generate measurement results.
Area, as well as the length of any manually drawn lines, arcs, curves, etc., and automatically generate measurement results.colony counting
Tri color LED hybrid light source, color temperature adjustment
Scientific research aims to accurately reflect the color of bacterial colonies, as traditional white LED lighting tends to produce bluish images. Long life, low power consumption, environmentally friendly three color LED mixed light, with a color temperature range of 3500K-8500k controlled by the ratio of warm and cool colors, captures the most realistic color of bacterial colonies.
Culture dish imaging system
Adopting SONY high-sensitivity and large area array CCD, it has the characteristics of ultra-low readout noise level, wide dynamic range, and high sensitivity design. Combined with a 10 megapixel F1.4 large aperture fixed focus lens (200Lp/mm) and suspended dark field illumination, it can clearly display small colonies, bubbles, and scratches in the deep layers of the culture medium.
Fully enclosed darkroom shooting
Adopting fully enclosed, wide light strip lighting technology and ergonomic porthole door design, it isolates the interference of ambient light, eliminates the light spot and halo phenomenon formed by the refraction of stray light in glass culture dishes, and provides light and shadow conditions for accurate live bacterial counting. The upper light source provides 360 degree flexible mixed light illumination, which can highlight the color and texture of the colony, making the wrinkles, depressions, and jagged edges of the colony surface more three-dimensional; The bottom light source is a crystal sharp suspended dark field illumination, which not only clearly outlines the outline of bacterial colonies, but also distinguishes the basal hyphae and aerial hyphae of fungi or actinomycetes.
Fourth generation intelligent recognition technology for bacterial colonies
The fourth generation colony counter of Xunshu is based on the international cutting-edge image segmentation technology "level set active contour model" as the core, creatively developing advanced image segmentation technologies such as "fast active contour model", "color level set active contour model based on RGB constraints", "multiphase level set active contour model" for microbial colony diversity. It has the advantages of strong noise resistance, good numerical stability, smooth and continuous segmentation boundaries, and can handle topological structures, achieving accurate counting of complex colonies.
Multi regional parallel statistics
In the field of medical research, there is often a need for separate statistical analysis of multiple regions, such as OPKA (regulated phagocytic bactericidal test) for testing the efficacy of pneumococcal vaccines, SBA (serum bactericidal test) for detecting the bactericidal ability of specific antibodies, plaque counting for virus titer determination, and various porous plate clone counts. Fast counting multi region statistical algorithms can easily achieve synchronized one click counting of any number of regions.
Advanced Tools - Background Text, Speckle Elimination
The symbols and stains marked with a marker pen at the bottom of the culture dish can interfere with the automatic recognition of bacterial colony images. The background restoration tool developed by Xunshu only requires two steps to restore the culture dish image to its original state, thereby improving the accuracy of colony image segmentation.
Colony screening
Double circle analysis
Xunshu provides specialized characteristic analysis tools for double circle problems such as antibacterial circle, transparent circle, color changing circle, and growth circle. By accurately measuring the outer circle diameter and colony diameter, the area ratio and diameter ratio of the two are automatically calculated. Automatically sort and locate corresponding colonies based on the size of the ratio, which can be used for screening antibiotics, enzyme preparations, organic acids, etc.
Multi strain classification and recognition
In microbial research, it is sometimes necessary to classify and count target bacteria in the presence of multiple bacterial mixtures. The example image shows a mixed probiotic preparation of Bacillus licheniformis and Bacillus subtilis, which utilizes the subtle differences in color, size, and contour between the two bacteria for accurate image recognition.
Color colony recognition
With the increasingly widespread use of chromogenic culture media, new requirements have been put forward in the fields of scientific research and detection: classifying and counting colonies of different colors at once. Traditional multi-color colony automatic classification generally uses the method of colored cubes, but the effect is often not good. The latest research by Xunshu Technology, "Multi color Clustering of Level Set Active Contour Model Based on RGB Constraints," incorporates the RGB model into the constraints of the CV level set active contour model and achieves ideal image segmentation results.
The description of colony morphology is necessary in the basic research of microorganisms. Because everyone's language is different, the traditional description is arbitrary. Xunshu has established a digital description system for colony morphology, which not only standardizes the characterization of bacteria, yeast, actinomycetes, and fungi, but also directly imports precise measurement data of colonies into the database. Especially for colony color, automatically generate color text descriptions based on the three-dimensional color data of the value points.
The traditional fungal research experiments, such as mycelial growth rate, fungal growth amount, mycelial growth inhibition rate, and indoor toxicity determination, use the cross method to measure the colony growth diameter. Due to the spread, looseness, and irregular edge divergence of most fungal colonies, there is a large human error in measurement, resulting in low efficiency. The "one click mold measurement" module of Xunshu can instantly measure the area, circumference, length, and length of large molds by clicking once on the edge of the colony with a "magic wand".
The four tiered system architecture of "system administrator, data administrator, operator, and reviewer" is divided into functions and permissions to ensure the security, integrity, and authenticity of data information.
System administrator: responsible for creating and managing accounts and login passwords for all operators and auditors.
Data administrator: responsible for archive management, sealing, and computer database management of all test data.
Operator: Responsible for testing, self checking, correcting, generating electronic reports, submitting for review, and printing reports on approved documents for culturing dish colonies
Auditor: Responsible for reviewing the test reports submitted by operators.
① Multi user password login, electronic signature, computer-generated operation review date;
② All operational procedures, such as images, dilution ratios, statistical tools, parameters used, test values, correction situations, etc., are automatically recorded in the database by the computer and cannot be modified by the operator;
③ By reproducing the testing environment and process, the reviewer can trace all the operations of the operator.
Antibacterial zone measurement
Szone multimodal measurement technology
The tube disk diffusion method requires a circular and clear edge of the antibacterial zone, but there may still be situations such as unclear or broken edges in the experiment. The S-zone antibacterial zone multi-mode measurement technology uses three different high-speed algorithms to accurately extract the pixels that make up the edge of the antibacterial zone, thus completing high-precision measurement.
Complies with the Chinese Pharmacopoeia 2020 edition two dose method, three dose method, and combined calculation requirements
Please. High definition imaging and high-precision digital measurement ensure the accuracy of potency determination. The relative error of repetitive self check is less than 0.01%; The relative error of uniformity self-test is less than 0.1%; The accuracy of potency measurement is greater than 99.7%.
Please. High definition imaging and high-precision digital measurement ensure the accuracy of potency determination. The relative error of repetitive self check is less than 0.01%; The relative error of uniformity self-test is less than 0.1%; The accuracy of potency measurement is greater than 99.7%.The issue of antibiotic residues has become one of the important factors affecting the safety of dairy products. In order to test whether β - lactase is added to milk, Xunshu provides a fast measurement and intelligent judgment software, which intelligently judges whether β - lactase is positive or negative through pure water verification, parallel sample detection, and average value calculation.
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Main functions and technical indicators
1、 Digital imaging of bacterial colonies and inhibition zones
1. Light source
2. Light path and lighting control
3. Optoelectronic conversion
2、 Colony analysis module
1. Basic colony counting function
2. Advanced colony counting function
3. Grid filter membrane and 3M test piece
4. Typical bacterial screening
5. Description of colony characteristics
6. Microbial limit analysis tool
7. Special Line Analysis
8. Advanced Tools
9. Calibration and Measurement
10. Image processing
3、 Data Security and Management
1. The four tiered system architecture of "system, data, operation, and review" is divided into functions and permissions to ensure the security, integrity, and authenticity of data information
2. Data storage and export
3. Watermark signature technology, tamper proof technology, and intelligent reconstruction technology for testing processes to achieve effective audit tracking
4. Anti tampering technology
5. Watermark signature technology
6. Intelligent refactoring technology for testing process
4、 Antibacterial zone analysis module
1. Multi mode measurement technology for Szone inhibition zone
2. Determination of antibiotic potency
3. Shubatan sensitive β - lactase test
5、 Microscopic Cell Analysis Module
1. Microscopic imaging
2. Image display and conversion
3. Microscopic image processing
4. Target measurement
5. Particle statistics
6. Drawing and Annotation
6、 Instrument specifications and configuration
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