Micro needle strength tester

A microneedle refers to an array containing multiple micro needles, with needle lengths typically ranging from tens of micrometers to a few millimeters, and a diameter of several tens of micrometers or less. Microneedle is an efficient, safe, and novel transdermal drug delivery technology that has advantages that cannot be achieved by other traditional transdermal drug delivery techniques. Firstly, microneedles break down the major barrier in transdermal drug delivery - the stratum corneum, which blocks drug delivery. This not only greatly improves the efficiency of drug delivery, but also makes transdermal delivery of large molecule drugs and hydrophilic drugs possible. Secondly, due to its small structural characteristics, microneedles can break through the barrier of the stratum corneum without touching the nerve tissue inside the dermis during application, achieving painless and minimally invasive drug delivery and improving patient compliance.

At present, many scholars have studied microneedles made of different materials, such as glass, sugar, metal, silicon, polymer, hydrogel, etc; There are also many different types of microneedles, such as hollow microneedles, solid microneedles, soluble microneedles, and swollen microneedles, which have been applied in local anesthesia, immunization, microsampling, DNA administration, skin beauty, protein and peptide drug delivery, and other fields. However, the commercialization of microneedle products is still relatively low at present, and there are many reasons for this, such as the existence of many mechanical problems during the microneedle insertion process, which affect its puncture effectiveness; Safety issues during the use of microneedles, such as harmful residues caused by microneedle breakage; Compared to other dosage forms, microneedles have a smaller drug loading capacity; The impact of minimally invasive administration of microneedles on the skin.

Among them, the puncture performance of microneedles is the decisive factor for their successful application, and also a key factor limiting the development and promotion of microneedles, especially for soluble microneedles prepared from polymer materials. During the puncture processDue to the unevenness of the skin and inevitable movement during the puncture process, microneedles are subjected to various forces. When the external force reaches a certain level, the microneedle will undergo deformation such as breakage and bending, which will affect its puncture performance. Therefore, microneedles need to have a certain mechanical strength to overcome the potential failures caused by these factors, and different puncture methods, biological factors, etc. can affect the puncture performance of microneedles.

1Micro needle strength testerIntroduction

The Shanghai Tengba microneedle strength tester has high accuracy and stability, making it very suitable for mechanical performance testing of small samples such as microneedles and micro force samples. It can obtain indicators such as yield force, fracture force, penetration force into skin and skin models, and elastic modulus of microneedles.

Microneedle fracture forceThe probe applies an axial force perpendicular to the base of the microneedle at a certain speed, and the force at the moment of sudden drop is the fracture force of the microneedle.

Micro needle insertion forceThe minimum force required for a microneedle to puncture the skin is the penetration force.

two、Micro needle strength testerPerformance characteristics

1 Test indicators：Fracture force, yield force, puncture force, puncture strength, elastic modulus, stress, strain and other indicators.

2 Instrument accuracy：0-1kg， Resolution accuracy: 0.0001g (software synchronized real-time display); Using replaceable load sensing components, future options for 0.5kg, 5kg, 10kg, 20kg, 30kg, 50kg, 100kg load sensing components can be selected according to customer needs.

3 Test moving distance：0-420mm， Distance accuracy: 0.0001mm (software synchronized real-time display); It can also be highly customized according to customer requirements.

4 Detection speed：0-50mm/s， Speed resolution: 0.001mm/s; Software configuration and control.

5 Measurement parametersIt can be used to measure multi-dimensional data such as load, time, displacement, strain, stress, load/width, load/thickness, elongation, etc.

6 Instrument protection functionOverload protection for force sensing elements and upper and lower limit protection for instruments.

7 External dedicated software：Switching between Chinese and English,Conduct texture analysis and physical property testing on various samples; Testing process: Equipped with a real-time display box, the detection process data and graph drawing are synchronously displayed in real time, and users can directly observe changes in the detection graph; Analysis process: No additional programming is required, testing is completed, users can directly select parameters, and the software automatically calculates and displays data results.

8 Test curve coordinatesThe horizontal and vertical coordinates of stress, strain, load, displacement, time, and elongation can be freely switched.

9 Types of Test MethodsCompression test, tensile test, peel test, tear test, fatigue test, creep test, relaxation test, custom test, etc. can be programmed according to the testing needs.

10 Results ProcessingEasy creation of custom reports and experimental graphs; The test data can be directly exported to Excel and other formats for operations such as drawing, saving, comparing, printing, and generating professional reports. Multiple texture curve graphs can be overlaid for comparative analysis, making it convenient and intuitive.