Fully automatic transdermal diffusion system

The Huarong TD-12AT PLUS fully automatic transdermal diffusion system includes a diffusion host and an automatic sampler, suitable for in vitro drug release and transdermal experiments of ointments, patches, and other formulations. Its main features include compliance with regulatory requirements, vertical diffusion pool design, precise temperature control, automatic exhaust bubbles, automatic sampling, high-precision flow path design and sampling, comprehensive user management and audit tracking functions, as well as support for paperless report management and remote system upgrades. Huarong provides a comprehensive technical service system to ensure the stability of instrument performance and the reliability of experimental results, bringing users a convenient and efficient operating experience.

Product Introduction

HuarongTD-12AT PLUSFully automatic transdermal diffusion systemIt consists of a diffusion host and an automatic sampler.TD-12The transdermal diffusion host consists of two sets6A diffusion pool for diffusion experiments. The Huarong transdermal diffusion system is suitable for in vitro drug release and transdermal experiments of ointments, patches, coatings, films, and aerosols, and studies the efficiency of drug penetration through the skin through a model of transdermal absorption. The specific technical features are as follows:

Key Features:

1.Compliant with regulatory requirements

HuarongTD-12AT PLUSFully automatic transdermal diffusion systemThe performance meets the requirements of regulations and standards such as the United States Pharmacopeia and the Technical Guidelines for Pharmaceutical Research of Chemical Generic Transdermal Patch in China. It is a reliable and highly reproducible method for determining the release of semi-solid dosage forms, and is currently the most widely used method.

2.Composition of diffusion pool

The diffusion pool is a vertical diffusion pool, mainly composed of a glass receptor chamber, a membrane placement chamber, a membrane, a sealed membrane cover, a transparent anti evaporation cover, etc. There is a liquid inlet at the bottom of the glass receptor chamber/The liquid extraction hole and the upper end of the membrane placement chamber are equipped with bubble discharge holes.

3. temperature control

①The diffusion system adopts dry heating method, which has high heating efficiency and accurate temperature control of the receiving chamber and donor chamber (deviation)≤±0.5℃）；

②Vertical diffusion pool anti evaporation cap+The dual insulation design of the body protective cover prevents solvent evaporation in the sample during the experimental process, while also preventing the temperature of the pool and sample from being affected by the external environment;

③Real time monitoring and recording of the temperature of the dry heating module and the receiving tank medium, and generating temperature curves;

④Each diffusion pool is equipped with an independent temperature monitoring module to monitor the temperature of the medium inside the diffusion pool, ensuring the accuracy of the temperature of the receptor medium;

⑤Same temperature fluid replacement design to avoid the impact of fluid replacement temperature fluctuations on in vitro release or transdermal experiments.

4.Selection of transdermal diffusion pool
①Material: Improved TypeFranzVertical diffusion pool, made of glass material, good heat transfer, fixed1.77cm2（φ=15mm）Release area;

②Quantitative administration: Quantitative rings of different thicknesses (thickness)1mm/2mm/3mm）Flexibly control different dosages of medication;

③Variable volume of diffusion tank: With different volumes of agitators, the volume of the diffusion tank can be flexibly changed;

④Adaptive compression device: spring+Knob design, adaptive clamping and adjustment of the gap between the receiving chamber and the donor chamber.

5.Automatic exhaust bubble

①Automatic exhaust design ensures that the skin or the lower surface of the filter membrane comes into contact with the receiving liquid throughout the entire experimental process;

②The diffusion pool automatically tilts as a whole, and as the medium released from the bottom of the diffusion pool is added, bubbles are discharged from the upper pipeline.

6.automatic sampling

①Automatic sampling design, adding and extracting media from the bottom of the diffusion pool, can achieve full flux sampling and partial sampling;

②Simultaneous operation on the same machine12Penetration testing of a sample, with two sets of upper and lower samples6+6(Reference)+Self developed), can set different temperatures and stirring speeds.

7.Flow path design
①Excellent flow path design, automatic lubrication and cleaning of the pipeline before sampling, and automatic emptying of the pipeline after sampling to avoid sample cross contamination;
② 12Each pool is an independent medium channel that can be operated simultaneously12Group release medium investigation;
③After the experiment is completed, the diffusion pool and pipeline system will be automatically cleaned and emptied;
④An online solvent deaerator can be optionally selected to deaerate the release medium.

8.Accurate sampling
①High precision imported injection pump can achieve fast and accurate sampling, with sampling errors≤±0.1ml；
②The sampler is automatically compatible with large test tubes（10ml）Sampling from liquid phase vials,39A sampling point.

9. Instrument Verification System

①After the instrument is installed, Huarong after-sales engineers will verify the hardware and software of the instrument;

②Can provide strict3QVerification service（IQTheOQThePQ）.

10. *The User Management System

①Can store all records and experimental reports;

②Allocated at least3Permission levels: system administrator, supervisor, operator;

③Can be preset1000A login account;

④Can establish user groups and set group member permissions;

⑤Customers can customize role permissions based on their own risk assessment;

⑥Can connect to enterprise servers and synchronize enterprise office domain accounts.

11. Equipped with audit tracking function

①Login records, operation records, experiment records, and system anomaly reports automatically generate accurate and consistent electronic data, and all electronic data is protected and cannot be altered or deleted;

②Large data storage capacity, capable of storing approximately25000Batch experiment report.

③can pass throughUDrive or connect to enterprise servers for real-time backup, allowing remote login to the enterprise server to view and print all records and experimental reports.

12. Paperless report management

The instrument can be connected to a network printer and stored locally on the machineUSearch and print disks, enterprise servers, etc. according to experimental requirements.

13. Remote upgrade of operating system

Huarong Instrument supports remote system upgrades and can provide free remote system upgrade services based on customer needs, saving time and manpower, and providing customers with a more friendly and convenient interface operation experience.

14. Complete technical service system

①Technical Support Huarong provides customers with fast and effective personal support through telephone, email, remote access, and on-site maintenance. Huarong operates nationwide20Multiple major cities have engineer stations to provide fast and efficient localized services;

②Spare parts service: Establish a spare parts warehouse, sign spare parts service agreements with key suppliers, shorten procurement cycles, and ensure the continuity of spare parts supply;

③Annual maintenance: Every year1-2Deep maintenance of the secondary system to eliminate hidden dangers;

④System upgrade: Assist customers in remotely upgrading and optimizing their existing systems;

⑤Verification: Arrange engineers to be stationed on site to comprehensively address customer emergency needs.