Cartilage Tissue Organ Chip Culture System

BiomimX

A clinically relevant in vitro model of human organs and pathology based on the regulation of mechanical microenvironment, innovative technology combines mechanical stimulation and 3D structure with the advantages of microsystems.

BiomemX is committed to developing innovative preclinical solutions that meet the 3R standards, which will change the standards for drug and medical device testing.

The system integrates 3D cell culture, mechanical force stimulation, uECG technology electrical recording, micro patterns, and microfluidics, and is capable of constructing cell patterned culture, tissue tissue interfaces, organs, and organ interactions, generating complex 3D human micro tissues in vitro and providing physiological or pathological mechanical stimulation to them, similar to a natural active microenvironment; Train cells to generate mature and functional miniature organs, thereby simulating the complex structure, microenvironment, and physiological/pathological functions of human organs. Capable of testing the toxicity/function of compounds to accurately reproduce the function of human organs and human disease states.

UBeat platformSupport the cultivation of three independent 3D microstructure models in a single device. The uBeat platform can obtainpatentThe uBeat technology provides controlled mechanical stimulation to microstructures. Specifically, the uBeat platform has suspension rods with geometric features that can load different product types, such as uBeat stretching and uBeat compression.

UBeat provides a 3D microenvironment and mechanical microenvironment control system for human multi organ chip models

--Dynamic mechanical force stimulation (tension, pressure stimulation)

--3D cultivation

--Micro pattern

--Microfluidics

--UECG technology electrical recording

UBeat technology can establish various organ models

In addition, other versions of these platforms in terms of deformation strength can be provided according to customer requirements!

UBox Mechanical Stimulation Control System

UBox is a control system that can provide mechanical stimulation for each uBeat platform. By connecting a pressurized air source to uCase, uBox allows operators to choose from several modes (characterized by frequency, duty cycle, and switch timing values), and even create personalized modes with customizable complexity.

--Control the type, magnitude, loading frequency, and loading cycle of mechanical force

--Cartilage and heart preset stimulation modes

--Customizable stimulation modes (frequency, duty cycle, and on/off timing)

UCase chip integrated combination device

--Organize up to 4 uBeat platforms together

--Optical transparency, convenient for real-time imaging analysis

--Can be sterilized under high temperature and pressure to maintain sterility

--Reusable

UKnee 3D osteoarthritis model

The first in vitro human chip based cartilage mini model of osteoarthritis (OA) can reproduce the condition of human joints. uKnee provides measurements of key indicators of OA, including changes in the balance of synthesis metabolism catabolism, inflammation, production of matrix degrading enzymes, and changes in key molecular pathways.

Animal models and other in vitro platforms cannot mimic human pathology to this extent. UKnee can be used to test the efficiency of potential novel anti OA candidate drugs in reversing pathology, making it the first in vitro platform capable of replicating OA disease.