Ultra sensitive factor electrochemiluminescence analyzer

MSD（S600）Ultra sensitive factor electrochemiluminescence analyzerIt is an immune analyzer based on the principle of electrochemiluminescence,The ability to measure 1-100 different indicators in 24, 96, and 384 well plates can be achieved,It has the characteristics of high sensitivity, wide linear range, simple and convenient operation, easy maintenance, and easy implementation of automation.Widely used in various fields such as biology, medicine, pharmacy, environment, food, immunology, and clinical research of drugs.

MSD（S600）Ultra sensitive factor electrochemiluminescence analyzerIntroduction:

The ultra sensitive multi factor electrochemiluminescence analyzer is a high-throughput analyzer based on the principle of electrochemiluminescence, which has the ability to measure multiple indicators in one well. It can achieve multifunctional detection of cytokines, biomarkers, phosphorylated proteins, hormones, antibody subtypes, drug toxicology, immunogenicity, and more.
Features:

1. High sensitivity: Based on the principle of electrochemiluminescence, the sensitivity is improved by 100 compared to conventional immunoassay techniques. The conventional sensitivity can reach 0.05pg/ml, and the ultimate sensitivity can reach fg/ml.
2. Wide linear range: A wide linear range of up to 6log, focusing on analytes ranging from picograms to nanograms in a single detection.
3. Low sample size: 1-25ul of sample is sufficient for multi index testing.
4. High reproducibility: intra plate CV<6-8%, inter plate CV<10%, inter batch CV<12%.
5. High load carrier: Processed graphite electrode plates can be coated with 10-100 times the amount of protein in traditional enzyme-linked immunosorbent assay plates. It can bind various biomolecules on the carrier, including but not limited to proteins, peptides, polysaccharides, nucleic acids, viruses, cell membranes, and cells.
Scope of application:

1. Cytokine research: Achieve multi factor research with a conventional sensitivity of 0.05pg/ml. Multi factor testing that meets GLP requirements.

2. Signal pathway research: simultaneous detection of phospho/total phosphorylated proteins can be achieved in just 4.5 hours.

3. Research on neurodegenerative diseases: Complex matrix samples such as cerebrospinal fluid (CSF) were used for detection without matrix effects.

4. Drug safety assessment: High sensitivity multi indicator testing that meets FDA standards.

5. Immunogenicity assessment: Compatible with high concentration blood drug interference up to 50ug/ml, achieving ADA detection sensitivity of<100ng/ml, meeting FDA requirements.

6. Antibody subtype typing: rapid identification of different subtypes in samples, with a sensitivity level of up to 0.1ng/ml

7. Antibody epitope analysis: Identify up to 10 different epitopes at once.

8. Multi valent vaccine efficacy evaluation: shortened to a 1.5-hour evaluation process.

9. Antibody affinity testing: affinity determination based on SET methodology, capable of analyzing up to 10-15 affinity samples.

10. Neutralization antibody assay: Based on cellular level, it is more in line with the requirements of actual organisms.

11. Cell level binding test: Cell Base Binding test, with a linear range of up to 6log, can identify the binding level and affinity of cell surface receptors to corresponding complement

12. Biological process residue determination: One detection can identify multiple host cells and multiple protein residues in purification processes, with basic sensitivity of nanograms to ensure identification effectiveness.
Basic operation method:

Firstly, encapsulate the antibodies/antigens/cells/nucleic acids onto a microporous graphite electrode plate; Then add the sample to be tested (such as blood, body fluids, etc.) to the electrode plate; The antigen/antibody/peptide/nucleic acid in the test substance binds with the pre coated substance in the plate to form a reaction complex. Add the detection antibody labeled with Tripyrimidine Ruthenium, put it into the instrument, and excite the bottom electrode of the plate to make Tripyrimidine Ruthenium emit electron luminescence from the donor. The luminescence intensity is correlated with the amount of the substance to be tested in the sample, from which qualitative or quantitative detection results can be obtained.
Purpose:

The high-sensitivity multi factor electrochemiluminescence instrument is a widely used biological testing and medical device, based on enzyme-linked immunosorbent assay, with the luminescence intensity of tris (pyrimidine) ruthenium for qualitative or quantitative analysis. This is a third-generation immunoassay technique that combines classical immunology with high-tech electrochemistry. It can be used for disease biomarker determination, monoclonal antibody screening, coagulation separation, antibiotic sensitivity, clinical toxicology evaluation of drugs, efficacy evaluation, and other aspects.

This instrument is suitable for clinical laboratory, microbiology, epidemiology, immunology, endocrinology, and agricultural and forestry sciences. Widely used in hospitals, blood stations, epidemic prevention stations, biological products and other departments.