Two dimensional liquid chromatography system/drug concentration detector GI-3000YT

Two dimensional liquid chromatography system/drug concentration detector GI-3000YT

Two dimensional liquid chromatographySystem/Drug Concentration Detector GI Shenzhen General Instrument

Model:GI-3000YT

Brand: Innovative Universal

Specification: all-in-one machine

picture1 Bid product:Physical photo of GI-3000YT two-dimensional liquid chromatography system

1. ProductsPurpose:

The product is used in clinical practice for qualitative and quantitative detection of organic and non-polar compounds derived from human blood samples,Scope of detectable drugs: antiepileptic drugs, psychiatric drugs, hypnotic sedatives, anti-tumor drugs, antibiotics, anti tuberculosis drugs, analgesic drugs, hormone drugs, circulatory system drugs, gastrointestinal drugs, or other drugs.

2、 Technicalcanparameter：

1. Comprehensive functional parameters of the detection system

1.1 Detection and analysis method: High performance liquid chromatography is used;

1.2 The instrument system adopts technology: two-dimensional liquid chromatography technology, with intuitive guidance and operation interface of two-dimensional system,Real time display of sample status for measurement;

1.3 Dual quaternary low-pressure constant flow pump system with eight online degassing flow paths;

1.4 with 10 inchesTFT high-resolution touch color screenIt also has two functions: direct control on the large screen and reverse control by computer software

1.5 Testing duration for each sample: 3-10 minutes;

1.6 System repeatability RSD6 (qualitative):≤0.5%；

1.7 System repeatability RSD6 (quantitative):≤1% ；

1.8 spiked recovery rate: within the range of 90% -110%;

1.9 onboardEquipped with concentration detection methods for commonly used therapeutic drugs in multiple disciplinesMore than 40 types；

1.10 Sample processing only uses dilution to remove protein;

1.11 The instrument has the function of unmanned operation after operation, which can achieve automatic measurement, operation, standby, light off, and shutdown functions.

1.12 All hardware of the instrument, except for the computer, is integrated into one box, which can optimize the layout of the instrument system pipeline, shorten the system flow path, reduce the dead volume of the system, optimize the system circuit layout, improve the electromagnetic compatibility performance of the equipment, and thus improve the overall performance indicators of the instrument;

1.13 With emergency function, it can urgently handle blood samples that require testing.

1.14 The instrument has multi item detection function, and can automatically detect multiple drugs in one batch. It can automatically replace different drug varieties and clean the pipeline without manual intervention.

1.15 The product meets the requirementsISO 13485 requirements

2、built-inquaterniongradientConstant flow pump:

2.1 Using servo motors to drive a constant current pump infusion system with two precision ball screws, the plunger stroke can be adjusted from 20uL to 140uL, allowing forGradient mixing can be completed within a constant flow pump, eliminating the need for an independent gradient mixer, thereby reducing the dead volume of the instrument system and improving the accuracy and speed of repeated detection,Improve the detection accuracy, stability, and durability of the system.

2.2 Constant flow pump pressure resistance: 45MPa

2.3 Built in online deaerator, the deaerator adopts high-efficiency technologyTeflon AF tube, deaerator dead volume<300uL

2.4 Built in four element gradient proportional valve, proportional valve lifespan>10 million times

2.5 It has real-time pressure detection display, high pressure limit, low pressure limit alarm, and automatic flow rate compensation with system pressure changes

2.6 Flow range:0.001-10.000ml/min； Set step size: 0.001mL/min

2.7 Flow accuracy:<±1%；

2.8 Gradient error: ± 1%

2.9 The pressure of the pump can be accurately displayed0.01MPa， Facilitating further observation and mastery of subtle changes in pressure fluctuations.

3、built-inautosampler：

3.1 Automatic sampler, to be usedHigh pressure injection,Mobile phase needle passingtechnologyNo need to clean the inner wall of the injection needle, the outer wall is automatically cleaned, which can reduceSample residue.

3.2 Automation of sample processing,Using a precision metering pump for automatic extraction, the injection volume can be changed at any time through a computer,No need to replace the quantitative ring.

3.3 The outer wall of the injection needle can be automatically cleaned before injection to reduce sample cross contamination

3.4 With an online processing capacity of 1000 µ l for ultra large samples (typical value of 500 µ l), the system automatically completes enrichment online.

3.5 Sample residue: less than0.005%

3.6 Sample Bottle Quantity: Compatible with 2 96 well plates or 2mL * 80 regular sample bottles

3.7 Injection linearity: ≥ 0.999

4. Built in UVUV detector:

4.1 Wavelength range:190nm-700nm；

4.2 Spectral bandwidth:5nm；

4.3 Wavelength indication error:≤±1nm；

4.4 Wavelength repeatability: ≤ 1nm

4.5 Baseline noise:≤±1×10^-5 AU(甲醇、1ml/min、254nm、20℃)；

4.6 Baseline drift:≤±3×10^-4 AU/h(甲醇、1ml/min、254nm、20℃)；

4.7 Detection concentration:≤2×10^-10G/ml (naphthalene);

4.8 Wavelength scanning: multi wavelength time programming（10 bands)

4.9 Measurement range: 0.0001 to 2.0000 AUFS

4.10 Pool volume:8μL；

4.11 The detector has computer software reverse control function

4.12 Detector adopts dual channel data and high precision24 bit AD conversion, signal sampling frequency up to 80Hz/s high-speed data collector, ensuring high-speed, low-noise, low drift, and ultra-high sensitivity detection of the detector.

4.13 Adopting a new typeHType flow pool, bidirectional convection, ensuring minimal fluctuations in the baseline

5、Built in comprehensive separation and analysis unit：

5.1 Temperature control range: Room temperature -10 ℃~60℃

5.2 Temperature control accuracy:≤±0.1℃；

5.3 There is no need for a sample buffer column between one-dimensional and two-dimensional columns. Precise valve control technology is used to quickly and accurately switch, directly completing sample impurity removal, enrichment, purification, and transfer to the two-dimensional analysis column. The purified sample is then separated and detected by the two-dimensional chromatography column to avoid sample contamination, making sample detection faster and achieving better separation and detection results.

5.4 Temperature can be controlled in both directions: cooling and heating, intelligent temperature control.

5.5 Temperature setting resolution:0.1℃

5.6 The integrated unit has computer software reverse control function

6. Built inHigh pressure dilutionPump:

6.1 Flow Range:0.001-10.000ml/min； Set step size: 0.001mL/min

6.2 Flow accuracy:<±1%；

6.3 Maximum pump pressure:45Mpa

6.4 Computer control, with online automatic dilution function. No matter the injection volume, there is no need for nitrogen blowing operation, fully automatic processing, eliminating the trouble of manual intervention.

1. chromatographyworkstation:

   7.1 The software meets the requirementsGMP requirementsUser permission management, audit tracking function

   7.2 Full Chinese operation menu, intuitive and convenient user-friendly interface

   7.3 The software is designed uniformly by the original factory and has independent settings for public and private instrument methods, analysis methods, and reporting methods. When modifying private methods, the public methods are not changed, which facilitates the establishment and management of sample table methods. The establishment, modification, and deletion of instrument methods, analysis methods, and reporting methods all have permission management and audit tracking functions, making the database more secure and efficient.

   7.4 It has a sample table batch processing function, which means that after the sample table is established, all sample tests can be completed with one click. After the sample is completed, automatic column flushing and intelligent shutdown can be set to achieve unmanned operation.

   7.5 The software should be highly integrated, with data setting, collection, analysis, and viewing completed in one software, and easy to operate.

   7.6 The software can perform full reverse control operation control, automatic data acquisition, spectrum processing, etc. on the system.

   7.7 The method files used can provide long-term storage and unified management of the analytical parameters, spectral data, and analysis reports of the chromatograph;

   7.8 The software has MySQL database management function, and all key data is stored in the database, with data import and export functions.

   7.9 The workstation has the ability to compare spectra in multiple forms, which is beneficial for chromatographic research;

   7.10 Control methodHas computer reverse control function.

   7.11 working methodImplement data collection, calculation, organization, storage, and printing on the front and rear consoles

   
   

   IIIInstrument configuration

   1Drug concentration detector/Two dimensional liquid chromatography a set

   Built in configuration:

   （1）Four element gradient constant flow pump Two sets

   （2）High pressure dilution pump a set

   （3）UVUV detector a set

   （4）Integrated Separation Analysis System a set

   （5）Automatic sampler a set

   （6）Degassing machine（8One set of Road Online System

   (7) Chromatography control software system a set

   (8) Analysis column a

   (9) One SPE solid-phase extraction column

   2. Supporting computer a set

   3. One matching printer

4、 After sales service:

The product comes with a three-year warranty, free software upgrades, and lifetime service provided by the manufacturer.

Two dimensional liquid chromatography system/drug concentration detector GI-3000YT

Explanation of professional terms:

ISO 13485 is a quality management system certification standard for the medical device industry. It is based on ISO 9001 and focuses more on the safety and effectiveness of medical devices, clarifying the design and production processes

The quality control requirements from production to after-sales are aimed at ensuring that medical devices comply with regulations and user needs, and are widely recognized and adopted in the field of medical devices.