Two dimensional liquid chromatography system (detection of blood lithium drug concentration)

Two dimensional liquid chromatography system (detection of blood lithium drug concentration)

Two dimensional liquid chromatographysystem/Blood drug concentration detector

Model: GI-6060

Brand: Innovative Universal

1Purpose:

Used clinically to analyze organic compounds derived from human blood samplesAnd inorganic ionic substancesQualitative and quantitative testing.Detectable drugs:Psychiatric drugs（Including blood lithium）Antiepileptic drugs, hypnotic sedatives, anti-tumor drugs, antibiotics, anti tuberculosis drugs, monoamines, analgesic drugs, circulatory system drugs, gastrointestinal drugs, and other inorganic ion drugs.

2、 Gong Gongcan andTechnical specifications：

1. Comprehensive functional parameters of the detection system

1.1 Detection and analysis methods: High performance liquid chromatography and ion chromatography are used;

★1.2The instrument system adopts technologies such as two-dimensional liquid chromatography and two-dimensional ion chromatography, with intuitive guidance and operation interface for the two-dimensional system;

★1.3 Dual quaternary low-pressure constant flow pump system, eight online deaerator and flow path;

★1.4 have5inchTFT high-resolution touch color screenAnd it has direct screen control andTwo functions of computer software reverse control；

1.5 Testing duration for each sample: 5-10 minutes;

1.6 SystemrepetitivenessRSD6 (qualitative)：≤0.5%；

1.7 SystemrepetitivenessRSD6 (quantitative)：≤1% ；

1.8 spiked recovery rate: within the range of 90% -110%;

1.9 onboardEquipped with concentration detection methods for commonly used therapeutic drugs in multiple disciplines60 or more;

1.10 The instrument has the function of unmanned operation after operation, which can achieve automatic measurement, operation, standbyTurn off the lightsstop function；

1.11 With emergency function, it can urgently handle blood samples that require testing;

1.12 The instrument has multi item detection function, and can automatically detect multiple drugs in one batch. It can automatically replace different drug varieties and clean the pipeline without manual intervention;

1.13 Sample processing automation，adoptPrecision metering pumpquantityAutomatic Extraction TechnologyChange the injection volume size at any time through the computerAnd it has eight independent mobile phases (reagents) and their flow paths. The equipment can automatically control the selection of different reagents and dosages, and perform online mixing and preparation of matching detection reagents required for various drugs;

1.14 The chromatographic column has strong compatibility, and a set of chromatographic columns can complete the detection of 60 drugs. Avoid frequent replacement of chromatography columns;

★1.15 We can provide the registration certificate of the original equipment's matching chromatography column;

2、doublequaterniongradientconstant flow pump(Built in)Combination pump system）：

★2.1 adoptdual servomotor，Independently separatedriveTwo rootsPrecision ball screw constant flow pump infusion system, plunger stroke2Adjustable from 0uL to 140uL,makeGradient mixing can be completed in a constant flow pump，removeIndependentGradient mixer，thusreduceInstrument systemDead volume，Improve the accuracy and speed of repeated detection in the system，Improve the detection accuracy, stability, and durability of the system；

2.2 Flow range:0.001-5.000ml/min； Set step size: 0.001mL/min；

2.3 Built in online deaerator, the deaerator adopts high-efficiency technologyTeflon AF tube, deaerator dead volume<300uL；

★2.4 Built in quaternary gradient proportional valve,System Two Four Element GradientsProportional valve lifespanall >110 million times；

2.5Equipped with real-time pressure detection display, high pressure limit, low pressure limit alarm, and automatic flow rate compensation with system pressure changes；

2.6 Traffic accuracy:<±1%；

2.7 Gradient error:±1%；

3High pressure dilutionpump(Built in)Combination pump system）：

3.1 Flow range:0.001-5.000ml/min，Set step size:0.001mL/min；

3.2 Traffic accuracy:<±1%；

3.3 Computer control, with online automatic dilution function. No matter the injection volume, there is no need for nitrogen blowing operation, fully automatic processing, eliminating the trouble of manual intervention.

4、autosampler：

4.1 Automatic sampler, to be usedHigh pressure injection,Mobile phase needle passingtechnologyNo need to clean the inner wall of the injection needle，Automatic cleaning of outer wall，canreduceSample residue；

4.2 Before injection, it is possible toautomatic cleaningInjection needle outer wall to reduce sample cross contamination；

4.3 1000 µ l ultra large sample online processing capability (typical value of 500 µ l), the system automatically completes enrichment online;

4.4 Sample bottle quantity: There are two injection methods, 80 positions (2mL ordinary sample bottle) or 192 positions (two 96 well plates)

4.5 Injection linearity:≥0.999；

5. Integrated Separation Analysis System：

★5.1 The system is compatible with both two-dimensional liquid chromatography and two-dimensional ion chromatography working modes, andTwo dimensional liquid chromatography system and two-dimensional ion chromatography systemAutomatically switch between organic compound drugs and inorganic ion drugs on the same device system for automatic detection,Contains the concentration of lithium carbonate drug.

5.2 Temperature control range：room temperature-10℃～60℃；

5.3 Temperature control accuracy:≤±0.1℃；

5.4 Temperature can be controlled in both directions:canRefrigeration and HeatingIntelligent temperature control;

5.5 Temperature setting resolution:0.1℃；

5.6 Integrated UnitEquipped with computer software anti control function

6、UVUV detector(Built in)Integrated Separation Analysis System）：

6.1 Wavelength range:190nm-700nm；

6.2 Spectral bandwidth:5nm；

6.3 Wavelength indication error:≤±1nm；

6.4 Wavelength repeatability:≤1nm

6.5 Baseline noise:≤±1×10^-5 AU(甲醇、1ml/min、254nm、20℃)；

6.6 Baseline drift:≤±3×10^-4 AU/h(甲醇、1ml/min、254nm、20℃)；

6.7 Detection concentration:≤2×10^-10G/ml (naphthalene);

6.8 Wavelength scanning: multi wavelength time programming（10 bands)；

6.9 Measurement range:0.0001～2.0000AUFS；

6.10 Pool volume:8μL；

6.11 DetectorEquipped with computer software anti control function

6.12 The detector adopts dual channel data and high precision24 bit AD conversion, signal sampling frequency up to 80Hz/s high-speed data collector, ensuring high-speed, low-noise, low drift, and ultra-high sensitivity detection of the detector.

7Bipolar conductivity detector unit（Built inIntegrated Separation Analysis System）：

★7.1 Bipolar Conductivity Detector, Range: 0.0001-16000 μ S, No Shift Required

7.2 Pressure resistance: 10Mpa (1500psi)

7.3 Instrument linearity: ≥ 0.999

7.4 Qualitative repeatability: ≤ 1.0%

7.5 Quantitative repeatability: ≤ 1.0%

8. Chromatographyworkstation:

8.1 Full Chinese operation menu, intuitive and convenient user-friendly interface

8.2The software hassatisfyGMP requirementsUser permission management,auditTracking function

8.3 softwareDesigned uniformly by the original factoryHaving independent public and private instrument methods、analytical method、Setting of reporting methodsfunctionWhen modifying private methods, do not change public methods, which facilitates the establishment and management of sample table methods. Instrument method、analytical methodandEstablishment of reporting methods、modify、DeleteallHaving permission management andauditTracking function makes the database more secure and efficient.It can meet the needs of both clinical testing and scientific experiments.

8.4 It has a sample table batch processing function, which means that after the sample table is established, all sample tests can be completed with one click. After the sample is completed, automatic column flushing and intelligent shutdown can be set to achieve unmanned operation.

8.5 The software needs to be highly integrated, with data settings、collect、Analyze and view a software that is easy to operate.

8.6 The software can perform full reverse control operation control, automatic data acquisition, spectrum processing, etc. on the system.

8.7 The method file used can analyze the parameters, spectral data, and analysis reports of the chromatographlongLong term storage and unified management;

8.8 The software comes withMySQL database management function, all key data is stored in the database, with data import and export functions.

8.9 The workstation has the ability to compare spectra in multiple forms, which is beneficial for chromatographic research;

8.10 Control methodHas computer reverse control function.

8.11 working methodImplement data collection, calculation, organization, storage, and printing on the front and rear consoles

IIIInstrument configuration

1、Combination pump system a set

among whichbuilt-in:

（1）Four element gradient constant flow pump Two sets

（2）High voltageDilution pump a set

（3）degassingMachine（8Road OnlineOne set of system

2. Automatic sampler a set

3. Integrated Separation Analysis System a set

Built in among them

（1）UVUV detector a set

（2）Bipolar conductivity detector a set

4. Chromatography control software system a set

5. accessories

（1）ChromatographyAnalysis column a

（2）SPESolid phase extraction column a

（3）Cation analysis chromatography column a

（4）Cation suppressor one

（5）Pre processingIon column a

2Supporting computer a set

3One matching printer

4、 After sales service

Product warranty for five years, softwarefreeUpgrade, the manufacturer provides lifelong service.

Two dimensional liquid chromatography system (detection of blood lithium drug concentration)