Two dimensional liquid chromatography drug concentration measurement

Two dimensional liquid chromatography drug concentration measurement

Two dimensional liquid chromatography

Model: GI-3000YT

Brand: Innovative Universal

Specification: all-in-one machine

1、 Product Usage:

The product is used in clinical practice for qualitative and quantitative detection of organic and non-polar compounds derived from human blood samples. The detectable drug range includes antiepileptic drugs, psychiatric drugs, hypnotic sedatives, anti-tumor drugs, antibiotics, anti tuberculosis drugs, analgesic drugs, hormone drugs, circulatory system drugs, gastrointestinal drugs, or other drugs.

GI-3000YTTwo dimensional liquid chromatographymainFunction andTechnical specifications：

1. Comprehensive functional parameters of the detection system

(1) Detection and analysis method: High performance liquid chromatography is used

(2) The instrument system adopts technology: two-dimensional liquid chromatography technology, with intuitive guidance and operation interface of two-dimensional system.

(3) All parts of the instrument's software and hardware are designed and manufactured by a single manufacturer to ensure overall consistency and strong stability of the instrument system

★ (4) Testing duration for each sample: 5-10 minutes

★ (5) Additive recovery rate: must be within the range of 90% -110%

(6) System repeatability RSD6 (qualitative):≤0.5%

(7) System repeatability RSD6 (quantitative):≤1%

★(8) There are over 40 methods for detecting the concentration of clinical therapeutic drugs on board.

(9) Sample processing only uses dilution to remove protein

(10) The work curve should remain stable within 30 working days

2Four yuanUltra high voltage resistanceConstant flow pump:

★ (1) The infusion system of the constant flow pump adopts a dual stepper motor, which independently drives two precision ball screws. The plunger stroke is adjustable from 20uL to 140uL, and can be easily set and adjusted by a computer.

★ (2) Equipped with a 5-inch 16:9 TFT high-resolution touch color screen (800 * 480 dot matrix). And it has two functions: direct control on the large screen and reverse control by computer software

(3) Constant flow pump with high pressure resistance: 50MPa

(4) Pressure pulsation: ≤± 0.02MPa.

(5) The constant flow pump system does not require an independent gradient mixer, and gradient mixing is completed inside the pump to reduce dead volume and improve the system's repeated detection accuracy.

(6) Built in online deaerator, equipped with high-efficiency Teflon AF tube, with a dead volume of less than 300uL

(7) Built in four element gradient proportional valve, proportional valve life>10 million times

(8) Precision ball screw driven dual plunger reciprocating pump, with real-time pressure detection display, high pressure limit, low pressure limit alarm, and automatic flow rate compensation with system pressure changes

(9) Flow range: 0.001-9.999ml/min; Set step size: 0.001mL/min

(10) Flow accuracy:<± 1%;

(11) The pressure of the pump can be displayed up to 0.01 MPa, which facilitates further observation and mastery of subtle changes in pressure fluctuations.

3、autosampler：

★(1) Automatic sampler, to be usedHigh pressure injection,Mobile phase needle passingtechnologyNo need to clean the inner wall of the injection needle, the outer wall is automatically cleaned, which can reduceSample residue.

(2) Using a high-pressure metering pump for automatic extraction, the injection volume can be changed at any time through a computer,No need to replace the quantitative ring.

(3) Before injection, the outer wall of the injection needle can be automatically cleaned to reduce cross contamination of the sample

(4) The online processing capability of 1000 µ l ultra large samples (typical value of 500 µ l), and the system automatically completes enrichment online.

(5) Sample residue: less than 0.005%

★(6) Number of sample bottle positions: not less than 144

(7) Power supply 220V±10%，50hz 150w

4UV detector:

(1)Wavelength range:190nm-700nm；

(2)Spectral bandwidth:5nm；

(3) Wavelength indication error: ≤± 1nm;

(4) Wavelength scanning: multi wavelength time programming（10Band)；

(5)Pool volume:8ML；

(6)The detector has a computer software anti control function

(7) The detector adopts dual channel data, high-precision 24 bit AD conversion, and a high-speed data collector with a signal sampling frequency of up to 80Hz/s, ensuring high-speed, low-noise, low drift, and ultra-high sensitivity detection of the detector.

(8)Adopting a new typeHType flow pool, bidirectional convection, ensuring minimal fluctuations in the baseline

5、Integrated Separation Analysis Unit：

(1)Temperature control range:5℃～80℃ (room temperature ＜25℃）；

(2)Temperature control accuracy:≤±0.1℃；

(3)The parameters of the integrated unit can be set and controlled by the chromatographic data processing workstation

(4)Temperature can be controlled in both directions: cooling and heating, intelligent temperature control.

(5)Temperature setting resolution:0.1℃

(6)The integrated unit has computer software reverse control function

6High pressure dilutionPump:

(1)Flow range:0.001-9.999ml/minSet step size:0.001mL/min

(2)Flow accuracy:<±1%；

(3)Large pump pressure:45mpa

（4）Computer control, with online automatic dilution function. No matter the injection volume, there is no need for nitrogen blowing operation, fully automatic processing, eliminating the trouble of manual intervention.

7. Chromatographyworkstation:

(1)The software hasMeet GMP requirementsUser permission management,auditTracking function

(2)The software comes withMySQL database management function, all key data is stored in the database, with data import and export functions.

★ (3) The software is designed by the original factory and has independent public and private instrument methods, analysis methods, and reporting methods. When modifying private methods, the public methods are not changed, which facilitates the establishment and management of sample table methods. The establishment, modification, and deletion of instrument methods, analysis methods, and reporting methods all have permission management and audit tracking functions, making the database more secure and efficient.

(4) It has a sample table batch processing function, which means that after the sample table is established, all sample tests can be completed with one click. After the sample is completed, automatic column flushing and intelligent shutdown can be set to achieve unmanned operation.

(5) The software should be highly integrated, with data setting, collection, analysis, and viewing completed in one software, and easy to operate.

(6) The main interface can complete most operations without switching back and forth between multiple interfaces.

Data analysis is based on actual collected data to ensure its authenticity.

(7) The software is written in pure object-oriented JAVA language, which has high scalability and cross platform running functionality.

(8)The software can perform full reverse control operation control, automatic data acquisition, spectrum processing, etc. on the system.

(9)The method files used can provide long-term storage and unified management of analytical parameters, spectral data, and analysis reports of the chromatograph;

(10)Full Chinese operation menu,Intuitive and convenient user-friendly interface;

(11)The workstation has the ability to compare spectra in multiple forms, which is beneficial for chromatographic research;

★(12)Control method:Equipped with computer reverse control function.

(13)working method:Implement data collection, calculation, organization, storage, and printing on the front and rear consoles

3、 After sales service:

The product comes with a three-year warranty, free software upgrades, and lifetime service provided by the manufacturer.

Two dimensional liquid chromatography drug concentration measurement