Tert butoxycarbonyl hexadecyl polyethylene glycol hydroxyl

Common names:Tert butoxycarbonyl hexadecyl polyethylene glycol hydroxyl

Description:

Tert butoxycarbonyl hexadecyl polyethylene glycol hydroxyl（t-Boc-PEG16-OH）It is a typical polyethylene glycol (PEG) derivative that combines a tert butoxycarbonyl (t-Boc) protecting group and sixteen ethylene glycol units (PEG16) with a hydroxyl (- OH) terminal functional compound. It has a wide range of applications in biomolecule modification, drug delivery, and synthetic chemistry, especially in protein, peptide synthesis, and polymer chemistry.

molecular structure

1. Tert butoxycarbonyl (t-Boc) protecting group

• Tert butoxycarbonyl (t-Boc) is a commonly used protective group, typically used to protect reactive functional groups such as amino (- NH ₂) or hydroxyl (- OH), preventing unwanted reactions during synthesis.

• The t-Boc group can be easily removed under acidic conditions, making it highly suitable for protection and deprotection operations during the synthesis process.

2. PEG16 chain

• This compound contains 16 ethylene glycol units (PEG16), endowing it with good hydrophilicity and biocompatibility.

• The presence of PEG chains can significantly improve the solubility and stability of molecules, and reduce protein adsorption and immunogenicity, making them widely used in drug delivery systems and biomedical research.

3. Hydroxyl (- OH) terminal

• The hydroxyl end is a functional group of the compound that can participate in further chemical reactions such as esterification, etherification, or coupling with other molecules.

Main properties

1. Protect functional groups

• The tert butoxycarbonyl (t-Boc) group protects the amino or hydroxyl groups in the molecule, preventing them from participating in the reaction under inappropriate reaction conditions, ensuring high selectivity and controllability of the synthesis.

2. Good water solubility

• Due to the introduction of PEG chains, this compound has good solubility in water and is suitable for reactions in aqueous environments, especially for biomolecule modification and drug delivery systems.

3. biocompatibility

• The length and properties of PEG16 make the compound highly biocompatible, reducing immune reactions and not causing strong immune reactions when used in vivo.

4. adjustability

• The t-Boc group can be easily removed under acidic conditions (such as using trifluoroacetic acid, etc.), leaving a reactive hydroxyl (- OH) functional group for subsequent chemical reactions or coupling.

application

1. Biomolecular modification

• T-Boc-PEG16-OH can be used to modify proteins, peptides, DNA, or other biomolecules, especially in synthetic processes that require protection of functional groups.

• The t-Boc group provides protection during the synthesis process, ensuring that other chemical reactions can proceed under controlled conditions.

2. Drug delivery system

• PEG16 chains can enhance the water solubility and stability of compounds, reduce drug degradation in vivo, and thus improve the bioavailability of drugs.

• This compound can be used to construct targeted drug delivery systems, connecting drug carriers and targeted molecules together.

3. Synthetic Chemistry and Polymer Chemistry

• This compound is commonly used in the synthesis of polymers, cross-linked molecules, or multifunctional compounds, especially in the construction of multifunctional materials, sensors, and biomedical materials.

4. crosslinking reaction

• The reactivity of the hydroxyl end allows the compound to crosslink with other molecules or polymers, forming more complex molecular networks.

Reaction conditions and purification

1. T-Boc to protect the reaction

• The t-Boc group can be removed under acidic conditions, and commonly used deprotection reagents include trifluoroacetic acid (TFA) or hydrogen chloride (HCl).

• The deprotection reaction is usually carried out in a solvent, and after removing the protective group, the hydroxyl (- OH) end is obtained, which is suitable for further reactions.

2. synthetic reaction

• Due to its hydroxyl terminal, this compound can undergo esterification, etherification, and other reactions with other chemical reagents to form new functionalized compounds.

• In the selection of solvents, DMSO, DMF and other solvents are commonly used, and the reaction conditions need to be adjusted according to the properties of the target compound.

3. Purification method

• Conventional purification methods, such as dialysis, gel filtration, reverse phase high performance liquid chromatography (HPLC) and other methods can be used to remove unreacted reagents and by-products.

Storage and operation precautions

1. store

• This compound should be stored in a dry and cool place to avoid high temperatures and moisture affecting its stability.

• When stored for a long time, it can be placed at -20 ° C to maintain stability.

2. operation

• Proper protective equipment should be worn during operation to avoid direct contact with chemical reagents.

• Due to the sensitivity of t-Boc groups to acid, excessive exposure to acidic environments should be avoided during the reaction process.

main advantages

1. Selective protection of functional groups

• The t-Boc group can effectively protect reactive functional groups and achieve selective control in the required chemical reactions.

2. biocompatibility

• The introduction of PEG chains ensures low immune response and good biocompatibility of the compound in vivo, making it suitable for drug delivery and biomolecule modification.

3. High reactivity and adjustability

• The hydroxyl terminal of this compound gives it high reactivity and tunability in chemical synthesis, making it easy for subsequent functionalization.

Tert butoxycarbonyl hexadecyl polyethylene glycol hydroxylIt is a PEG derivative with protective groups, widely used in biomolecule modification, drug delivery systems, and chemical synthesis. The introduction of t-Boc protecting groups can precisely control the reaction process, ensuring high selectivity and adjustability, and has important application value.

Purity: 90%+

Packaging: Bottled!

Origin: Xi'an

Purpose: Scientific research!

Specification: mg/g

Kind reminder: For scientific research only, not for human experiments!

About us: Xi'an Huirui Biotechnology's main business directions include synthetic phospholipids, polymer polyethylene glycol derivatives, block copolymers, paramagnetic/superparamagnetic nanoparticles, nanogold and nanogold rods, near-infrared fluorescent dyes, reactive fluorescent dyes, fluorescently labeled dextran BSA and streptavidin, protein crosslinkers, small molecule PEG derivatives, click chemistry products, dendritic polymers, cyclodextrin derivatives, macrocyclic ligands, fluorescent quantum dots, hyaluronic acid derivatives, graphene or graphene oxide, carbon nanotubes, fullerenes, etc. We also provide a variety of customized product services!

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The above information is provided by the editor kx and is only for scientific research purposes!