N3-PEG35-CH2CH2Br， Small molecule PEG

Common names:N3-PEG35-CH2CH2Br， Small molecule PEG

Description:

N3-PEG35-CH2CH2Br， Small molecule PEGIt is a polyethylene glycol (PEG) derivative containing azide groups (- N ∝) and bromoethyl groups (- CH ₂ CH ₂ Br). It consists of a PEG chain consisting of 35 ethylene glycol units combined with two active groups (azide group and bromoethyl group), exhibiting high reactivity and multifunctionality.

molecular structure

1. Azide group (- N ∝)

• The azide group is a reactive functional group commonly used in 'click chemistry' reactions, especially with triphenylphosphine (TPP) or other alkynyl compounds.

• It can react with various molecules and is widely used for biomolecule labeling, cross-linking, and coupling reactions.

2. PEG35 chain

• This compound is composed of 35 ethylene glycol units, providing good water solubility, low immunogenicity, and biocompatibility.

• The presence of PEG chains can enhance the stability of molecules in aqueous solutions and reduce immune reactions in vivo.

3. Bromoethyl group (- CH ₂ CH ₂ Br)

• Bromoethyl group is a common reactive functional group that can react with various nucleophilic reagents, especially suitable for nucleophilic substitution reactions with amino and thiol groups.

• Its reactivity makes this compound widely used in molecular coupling and polymer synthesis.

Main properties

1. Hydrophilicity and water solubility

• N₃- PEG35-CH ₂CH₂BrDue to the presence of PEG chains, it has excellent hydrophilicity and water solubility.

• The hydrophilicity of PEG contributes to the distribution and stability of molecules in living organisms.

2. reactivity

• Diazo groupHighly reactive, especially suitable for click chemistry reactions with triphenylphosphine (TPP) or molecules containing alkynyl groups.

• Bromoethyl groupHas nucleophilicity and can react with amino and thiol groups to form stable covalent bonds.

3. biocompatibility

• PEG chains provide lower immunogenicity, making the compound biocompatible in drug delivery and biomedical applications.

application

1. molecular coupling

• The azide group can undergo click chemistry reactions with alkynyl molecules or triphenylphosphine (TPP), and is widely used for labeling and modification of biomolecules such as proteins, peptides, and antibodies.

• Bromoethyl groups can react with nucleophilic reagents such as amino groups and thiol groups, and are widely used in coupling and crosslinking reactions.

2. Drug delivery system

• This compound can be used as a drug carrier, and PEG chains can improve the water solubility and stability of drugs, while reducing immune reactions in the body.

• The reactivity of bromoethyl and azide groups makes it suitable for targeted delivery and controlled release of drugs.

3. Surface modification and functionalization

• It can be used to modify the surface of nanoparticles, microparticles, or other biomaterials, enhancing their biocompatibility, stability, and functionalization.

• The reactivity of azide groups and bromoethyl groups makes it suitable for multifunctional material design.

4. Polymer synthesis and crosslinking

• The combination of azide groups and bromoethyl groups allows this compound to be used to construct cross-linked networks, form multifunctional polymers or materials, and be suitable for various chemical and biological studies.

Reaction conditions and purification

1. coupling reaction

• Diazo groupIt usually reacts with molecules containing alkynyl groups or triphenylphosphine for click chemistry reactions, usually in organic solvents such as DMSO.

• Bromoethyl groupCan undergo nucleophilic substitution reactions with amino and thiol groups, often using organic solvents (such as DMF, DMSO) and appropriate alkaline conditions.

2. Purification method

• After the reaction is completed, it is often purified by dialysis, gel filtration or high performance liquid chromatography (HPLC) to remove unreacted reagents and by-products.

Storage and operation precautions

1. store

• This compound should be stored in a dry, cool place to avoid the effects of high temperature and humidity.

• Bromoethyl and azide groups are sensitive to air and moisture, and should be avoided from exposure to humid environments.

2. operation

• During operation, it is recommended to wear appropriate protective equipment such as gloves and goggles to avoid direct contact with chemical reagents.

• Due to the strong nucleophilicity of bromoethyl groups, attention should be paid to avoiding reactions with inappropriate chemical reagents.

main advantages

1. versatility

• The combination of azide and bromoethyl groups makes the compound highly reactive, capable of various chemical reactions, and suitable for different coupling and crosslinking strategies.

2. Good water solubility and biocompatibility

• The PEG moiety provides good water solubility and biocompatibility, reducing immune reactions and non-specific cellular absorption.

3. High reactivity

• The presence of azide and bromoethyl groups makes the compound highly reactive in various chemical reactions, making it suitable for click chemistry, coupling, and cross-linking reactions.

N₃- PEG35-CH ₂CH₂BrIt is a functionalized polyethylene glycol derivative with good water solubility, biocompatibility, and high chemical reactivity, widely used in fields such as drug delivery, molecular coupling, surface modification, and polymer synthesis.

Purity: 90%+

Packaging: Bottled!

Origin: Xi'an

Purpose: Scientific research!

Specification: mg/g

Kind reminder: For scientific research only, not for human experiments!

About us: Xi'an Huirui Biotechnology's main business directions include synthetic phospholipids, polymer polyethylene glycol derivatives, block copolymers, paramagnetic/superparamagnetic nanoparticles, nanogold and nanogold rods, near-infrared fluorescent dyes, reactive fluorescent dyes, fluorescently labeled dextran BSA and streptavidin, protein crosslinkers, small molecule PEG derivatives, click chemistry products, dendritic polymers, cyclodextrin derivatives, macrocyclic ligands, fluorescent quantum dots, hyaluronic acid derivatives, graphene or graphene oxide, carbon nanotubes, fullerenes, etc. We also provide a variety of customized product services!

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The above information is provided by the editor kx and is only for scientific research purposes!