Serum drug concentration detector

GI-3000YMSerum drug concentration detector

And canTesting drugsProduct type

Model: GI-3000YM

Brand: Innovative Universal

Specification: all-in-one machine

Product Name: Two dimensional liquid chromatographysystem /Blood drug concentration detector Model: GI-3000YM

1. ProductsPurpose:

Used in clinical practice for qualitative and quantitative detection of organic compounds derived from human blood samples,Scope of detectable drugs: psychiatric drugs, antiepileptic drugs, hypnotic sedatives, anti-tumor drugs, antibiotics, anti tuberculosis drugs, monoamines, analgesic drugs, circulatory system drugs, gastrointestinal drugs, or other drugs.

2、 Gong Gongcan andTechnical specifications：

1. Comprehensive functional parameters of the detection system

1.1 Detection and analysis method: High performance liquid chromatography is used;

1.2 The instrument system adopts technology: two-dimensional liquid chromatography technology, with intuitive guidance and operation interface of the two-dimensional system, which can display the real-time status of the measured sample;

★1.3 Dual quaternary low-pressure constant flow pump system, eight channel online deaerator and flow path.

★1.4 has 10Inch TFT high-resolution touch color screenIt also has two functions: direct control on the large screen and reverse control by computer software

1.5 Testing duration for each sample: 5-10 minutes;

1.6 System repeatability RSD6 (qualitative): ≤ 0.5%;

1.7 System repeatability RSD6 (quantitative): ≤ 1%；

1.8 spiked recovery rate: within the range of 90% -110%;

1.9 Onboard equipped with 40 commonly used methods for detecting the concentration of therapeutic drugs in multiple disciplines;

The instrument has the function of unmanned operation after operation, which can achieve automatic measurement, operation, standby, light off, and shutdown functions.

1.11 has emergency function, which can urgently handle blood samples that need to be tested.

1.12 The instrument has multi item detection function, and can automatically detect multiple drugs in one batch. It can automatically replace different drug varieties and clean the pipeline without manual intervention.

★1.13 Sample processing automation, using precision metering pump volume automatic extraction technology, and changing the injection volume size at any time through a computer; And it has eight independent mobile phases (reagents) and their flow paths. The equipment can automatically control the selection of different reagents and dosages, and mix and prepare various drugs online with the required supporting detection reagents.

1.14 The chromatographic column has strong compatibility, and a set of chromatographic columns can complete the detection of 40 drugs. Avoid frequent replacement of chromatography columns.

2、built-inquaterniongradientConstant flow pump:

★2.1 Adopting dual servo motors to independently drive two precision ball screw constant flow pump infusion systems, the plunger stroke is adjustable from 20uL to 140uL, enablingGradient mixing can be completed within a constant flow pump, eliminating the need for an independent gradient mixer, thereby reducing the dead volume of the instrument system and improving the accuracy and speed of repeated detection,Improve the detection accuracy, stability, and durability of the system.

2.2 Flow range: 0.001-10.000ml/min； Set step size: 0.001mL/min

2.3 Built in online deaerator, equipped with high-efficiency Teflon AF tube, with a dead volume of less than 300uL

★2.4 Built in quaternary gradient proportional valve, analyzing quaternary gradientsProportional valve lifespan >50 million cycles, with a lifespan of over 10 million cycles for the pre-processing quaternary gradient proportional valve,

2.5 It has real-time pressure detection display, high pressure limit, low pressure limit alarm, and automatic flow rate compensation with system pressure changes

2.6 Flow accuracy:<± 1%;

2.7 Gradient error: ± 1%

3、built-inautosampler：

3.1 Automatic sampler should use high-pressure injection and mobile phase needle passing technology, without the need to clean the inner wall of the injection needle. The outer wall should be automatically cleaned to reduce sample residue.

3.2 The outer wall of the injection needle can be automatically cleaned before injection to reduce sample cross contamination

3.3 The online processing capability of 1000 µ l ultra large samples (typical value of 500 µ l), and the system automatically completes enrichment online.

3.4 Sample residues:Less than 0.005%

3.5 Number of sample bottle positions:60 positions (2mL regular sample bottle)

3.6 Injection linearity: ≥ 0.999

4. Built in UVUV detector:

4.1 Wavelength range: 190nm-700nm;

4.2 Spectral bandwidth: 5nm;

4.3 Wavelength indication error: ≤± 1nm;

4.4 Wavelength repeatability: ≤ 1nm

4.5 Baseline noise: ≤± 1 × 10^-5 AU(甲醇、1ml/min、254nm、20℃)；

4.6 Baseline drift: ≤± 3 × 10^-4 AU/h(甲醇、1ml/min、254nm、20℃)；

4.7 Detection concentration:≤2×10^-10G/ml (naphthalene);

4.8 Wavelength scanning: multi wavelength time programming (10 bands)

4.9 Measurement range: 0.0001 to 2.0000 AUFS

4.10 Linear range: ≥ 10⁴

4.11 Pool volume: 8 μ L;

4.12 detectorEquipped with computer software anti control function

4.13 The detector adopts dual channel data, high-precision 24 bit AD conversion, and a high-speed data collector with a signal sampling frequency of up to 80Hz/s, ensuring high-speed, low-noise, low drift, and ultra-high sensitivity detection of the detector.

5、Built in comprehensive separation and analysis unit：

5.1 Temperature control range: room temperature-10℃～60℃

5.2 Temperature control accuracy: ≤± 0.1 ℃;

★5.3 By using online caching technology, the entire system only requires two chromatography columns, and there is no need for a sample caching column (third column) between one-dimensional and two-dimensional columns. Central cutting technology and precision valve control technology are used to quickly and accurately switch, directly completing sample impurity removal, enrichment, purification, and transfer to the two-dimensional analysis column. The purified sample is then separated and detected by the two-dimensional chromatography column to avoid sample contamination, making sample detection faster and separation detection more effective.

5.4 Temperature can be controlled in both directions:Capable of cooling and heating, with intelligent temperature control.

5.5 Temperature setting resolution: 0.1 ℃

5.6 Comprehensive unit has computer software reverse control function

6. Built inHigh pressure dilutionPump:

6.1 Flow range: 0.001-10.000ml/min； Set step size: 0.001mL/min

6.2 Flow accuracy:<± 1%;

6.3 Maximum pump pressure: 50Mpa

6.4 Computer control, with online automatic dilution function. No matter the injection volume, there is no need for nitrogen blowing operation, fully automatic processing, eliminating the trouble of manual intervention.

7chromatographyworkstation:

7.1 Full Chinese operation menu, intuitive and convenient user-friendly interface

7.2 The software hasMeet GMP requirementsUser permission management, audit tracking function

★7.3 The software is designed uniformly by the original factory and has independent settings for public and private instrument methods, analysis methods, and reporting methods. When modifying private methods, the public methods are not changed, which facilitates the establishment and management of sample table methods. The establishment, modification, and deletion of instrument methods, analysis methods, and reporting methods all have permission management and audit tracking functions, making the database more secure and efficient. It can meet the needs of both clinical testing and scientific experiments.

7.4 It has a sample table batch processing function, which means that after the sample table is established, all sample tests can be completed with one click. After the sample is completed, automatic column flushing and intelligent shutdown can be set to achieve unmanned operation.

7.5 The software should be highly integrated, with data setting, collection, analysis, and viewing completed in one software, and easy to operate.

7.6 The software can perform full reverse control operation control, automatic data acquisition, spectrum processing, etc. on the system.

7.7 The method file used can provide detailed analysis parameters, spectral data, and analysis reports for the chromatographLong term storage and unified management;

The 7.8 software has MySQL database management function, where all key data is stored in the database and has data import and export functions.

7.9 The workstation has the ability to compare spectra in multiple forms, which is beneficial for chromatographic research;

7.10 Control mode: Equipped with computer reverse control function.

7.11 Working method: Implement data collection, calculation, organization, storage, and printing on the front and back desk

IIIInstrument configuration

1、Two dimensional liquid chromatographysystem a set

Built in configuration:

（1）Four element gradient constant flow pumpTwo sets

（2）High voltageDilution pumpa set

（3）UVUV detector a set

（4）Integrated Separation Analysis Systema set

（5）Automatic samplera set

（6）Degassing machine（8Road OnlineOne set of system

（7）A set of chromatographic control software system

（8）Analyze one column

（9）SPESolid phase extraction columna

2Supporting computer a set

3One matching printer

7、 After sales service:

The product comes with a three-year warranty, free software upgrades, and lifetime service provided by the manufacturer.

Simply put, the production process of GMP tubes and the experimental process of GLP tubes are both aimed at ensuring the quality and safety of products or research.

Serum drug concentration detector