Removing serum albumin from crab eating macaques

Removing serum albumin from crab eating macaquesIt is a serum product obtained by efficiently removing albumin from the serum of healthy crab eating macaques (Macaca fascicularis, Cynomolgus Monkey) using specific affinity chromatography technology. Albumin is the protein with the highest content in serum (accounting for 50-60% of total protein). In proteomics, biological analysis, and immune detection experiments, it can seriously mask the signal of low abundance proteins, leading to a decrease in experimental sensitivity. This product efficiently removes albumin while preserving the natural structure and biological activity of other serum proteins to the greatest extent possible, making it an essential key reagent in preclinical research of non-human primates. The genetic similarity between crab eating macaques and humans is as high as 93%, and their serum protein profile is highly similar to that of humans. They are the most commonly used non-human primate experimental animals in drug development, toxicology evaluation, and disease model research.

Core features:

High specificity monoclonal antibody affinity chromatography

Specific affinity chromatography

Albumin removal rate>99%

Strictly follow the ethical regulations for experimental animals and comply with the drug application process

Specification: 10mL

Storage method: ≤ -70 ℃

Transportation conditions: Dry ice

Main application scenarios

1. Proteomics and biomarker discovery

Serum proteomics analysis: significantly improves the detection sensitivity of low abundance proteins, and can identify 2-3 times more proteins

Screening of disease biomarkers: discovery and validation of differentially expressed proteins in crab eating monkey disease models

Study on the mechanism of drug action: analysis of changes in serum protein expression profile before and after drug treatment

2. Drug development and preclinical evaluation

Study on drug protein binding rate: accurate determination of the binding characteristics between small molecule drugs and non albumin serum proteins

Pharmacokinetic studies: Evaluating the distribution and elimination patterns of drugs in non-human primates

Toxicological research: detecting drug-induced changes in serum protein expression and evaluating drug toxicity

3. Immunology and Biological Analysis

Western blot: eliminates interference from albumin bands and clearly displays the target protein

Enzyme linked immunosorbent assay (ELISA): reduces non-specific background and improves detection signal-to-noise ratio

Antibody drug development: used for the detection of drug-resistant antibodies (ADA) and stability research of therapeutic proteins

Related products:

Removing serum albumin from crab eating macaquesIPHASE Cynomolgus Monkey Albumin Depleted Serum

Removing Albumin from Human Serum IPHASE

Simultaneously removing albumin, IgG serum/albumin, and IgG double removal serum

Complement serum

Purified Cynomolgus Monkey Albumin IPHASE

IPHASE Purified Human Albumin

Other species and strains can be customized for production

IPHASE/Huizhi Heyuan is the most professional biological matrix supplier in China, which can provide blank biological matrices such as real collected serum, plasma, whole blood, bile, cerebrospinal fluid, aqueous humor, vitreous humor, breast milk, urine, feces, tissue homogenates, as well as simulated matrices/artificial matrices such as artificial plasma, artificial urine, artificial cerebrospinal fluid, artificial aqueous humor, etc. It can remove IgG serum, IgG plasma, IgM serum, C1q serum and other specific component matrices; And purified proteins such as IgG, IgM, C1q, etc.