N3-PEG36-CH2CH2COONHS Ester， Small molecule PEG

Common names:N3-PEG36-CH2CH2COONHS Ester， Small molecule PEG

Description:

N3-PEG36-CH2CH2COONHS Ester， Small molecule PEGIt is a compound that combines azide groups (- N3), polyethylene glycol (PEG) chains, and active ester groups (- COONHS). This compound is widely used in fields such as biomolecule coupling, drug delivery systems, and materials science due to its unique chemical structure. It combines the high reactivity of azide groups, the biocompatibility of PEG chains, and the efficient coupling ability of NHS ester groups, making it suitable for various chemical reactions.

molecular structure

1. Azide group (- N ∝)

• The azide group is a highly reactive functional group commonly used in 'click chemistry' reactions, capable of reacting with alkynyl molecules or triphenylphosphine (TPP).

• Its high reactivity makes it very useful in molecular labeling, crosslinking, and coupling.

2. PEG36 chain

• The PEG chain composed of 36 ethylene glycol units provides good hydrophilicity, low immunogenicity, and biocompatibility.

• The presence of PEG chains can enhance the water solubility and stability of the compound, reduce immune reactions, and improve its distribution in biological systems.

3. NHS ester group (- COONHS)

• NHS esters are highly efficient nucleophiles that can react with amino groups (such as amino groups on proteins, peptides, etc.) to form stable amide bonds.

• NHS ester groups are widely used in biomolecule coupling and can achieve efficient and selective coupling reactions under mild conditions.

Main properties

1. Hydrophilicity and water solubility

• Due to the presence of PEG chains,N₃- PEG36-CH ₂CH₂ COONHS EsterHas good hydrophilicity and water solubility, and can maintain stability in aqueous solutions.

2. reactivity

• Diazo groupHas chemical reactivity and is suitable for click chemistry reactions with alkynyl molecules, triphenylphosphine (TPP), etc.

• NHS ester groupCan react with amino groups to form stable amide bonds, suitable for coupling proteins, peptides, and other molecules.

3. biocompatibility

• Due to the presence of PEG chains,N₃- PEG36-CH ₂CH₂ COONHS EsterIn biomedical applications, it has low immunogenicity and can reduce adverse biological reactions.

application

1. molecular coupling

• Diazo groupIt can be coupled with molecules containing alkynyl groups or triphenylphosphine (TPP) through chemical reactions, and is widely used for biomolecule labeling, modification, and crosslinking.

• NHS ester groupIt can react with molecules containing amino groups such as proteins and peptides to form stable couplings and amide bonds, commonly used for connecting biomolecules.

2. Drug delivery system

• This compound can be used as a drug carrier, and PEG chains can improve the solubility and stability of drugs, while reducing their immunogenicity.

• The reaction between NHS ester groups and amine groups on drug molecules can connect drugs with carriers or other molecules, enhancing drug targeting and efficacy.

3. Biomarkers and surface modifications

• It can be used to modify the surface of nanoparticles, microparticles, or other biomaterials, enhancing their biocompatibility and functionality.

• The combination of azide groups and NHS ester groups enables the compound to be used in multifunctional material design, enhancing material performance.

4. Polymer synthesis and crosslinking

• This compound can be used to synthesize multifunctional polymers or materials, with high reactivity, suitable for crosslinking and functionalization synthesis.

Reaction conditions and purification

1. coupling reaction

• Diazo groupCan undergo click chemistry reactions with alkynyl molecules or triphenylphosphine (TPP) under mild conditions, usually using dimethyl sulfoxide (DMSO) or aqueous buffer as solvents.

• NHS ester groupUnder neutral or slightly alkaline conditions, organic solvents such as DMSO and DMF are often used as reaction media to react with amino groups.

2. Purification method

• After reaction, dialysis, gel filtration or high performance liquid chromatography (HPLC) can be used for purification to remove unreacted reagents and by-products.

Storage and operation precautions

1. store

• This compound should be stored in a dry, cool place to avoid the effects of high temperature and humidity.

• The azide group is sensitive to moisture, and it is recommended to store it in an inert atmosphere to avoid reacting with moisture in the air.

2. operation

• Appropriate protective equipment such as gloves and goggles should be worn during operation to avoid direct contact with chemical reagents.

• Avoid exposing it to strong light and moisture to maintain its stability.

main advantages

1. versatility

• The combination of azide groups and NHS ester groups gives the compound high flexibility in coupling, crosslinking, labeling and other reactions, making it suitable for various chemical strategies.

2. Good water solubility and biocompatibility

• PEG chains provide good water solubility and biocompatibility, reducing immune reactions and increasing the stability of molecules in vivo.

3. High reactivity and efficiency

• The high reactivity of the azide group and NHS ester group enables the compound to rapidly react with the target molecule under mild conditions.

N₃- PEG36-CH ₂CH₂ COONHS EsterIt is a multifunctional PEG derivative with good water solubility, biocompatibility, and high reactivity, widely used in fields such as molecular coupling, drug delivery systems, material functionalization, and polymer synthesis.

Purity: 90%+

Packaging: Bottled!

Origin: Xi'an

Purpose: Scientific research!

Specification: mg/g

Kind reminder: For scientific research only, not for human experiments!

About us: Xi'an Huirui Biotechnology's main business directions include synthetic phospholipids, polymer polyethylene glycol derivatives, block copolymers, paramagnetic/superparamagnetic nanoparticles, nanogold and nanogold rods, near-infrared fluorescent dyes, reactive fluorescent dyes, fluorescently labeled dextran BSA and streptavidin, protein crosslinkers, small molecule PEG derivatives, click chemistry products, dendritic polymers, cyclodextrin derivatives, macrocyclic ligands, fluorescent quantum dots, hyaluronic acid derivatives, graphene or graphene oxide, carbon nanotubes, fullerenes, etc. We also provide a variety of customized product services!

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