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Shilian Boyan (Beijing) Technology Co., Ltd
Monosomy3Uveal Melanoma Lines reagent
NegotiableUpdate on 05/06
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Overview
Monosomy3Uveal Melanoma Lines reagent $r $n melanoma labeled HMB45, S100, and MCSP cells were positive $r $nUPMM-1-Monosomy3; GNAQ, R183 mutation (retaining the status of chromosome 3 in the primary tumor) $r $nUPMM-2-Monosomy 3; GNAQ, Q209 mutation (chromosome 3 has been duplicated (allelic cleavage) and exists in the background of subtetraploid karyotype)
Product Details
Monosomy3Uveal Melanoma Lines reagent
Monosomy3Uveal Melanoma Lines reagent
The UPMM-1 and UPMM-2 cell lines are derived from different donors of primary uveal melanoma tumors with monocytes.
emphasize:
- Melanoma markers HMB45, S100, and MCSP cells are positive
- UPMM-1-Monosomy 3; GNAQ, R183 mutation (retaining the status of chromosome 3 in the primary tumor)
- UPMM-2-Monosomy 3; GNAQ, Q209 mutation (chromosome 3 has been duplicated (allelic cleavage) and exists in the background of subtetraploid karyotype)
Uveal melanoma (UM) is an eye cancer (melanoma) that involves the iris, ciliary body, or choroid (collectively referred to as the choroid). Tumors originate from pigment cells (melanocytes) within the choroid, which color the eyes. The main UM can be divided into two main categories. Metastatic progression is typically observed in a type of UM characterized by monosomy 3, but is rarely seen in tumors with trisomy 3. Therefore, the 3rd monomeric cell line is suitable for analyzing the mechanisms and pathways leading to metastatic progression. There is a huge market demand, as currently only one alternative cell line, Unit 3, is available
technical indicators
| Product Category: | cell line |
| biology | human |
| Login ID: | UPMM-1：CVCL_C299 |
| resources: | Uveal melanoma |
| Passage culture: | Split once a week |
| Growth conditions: | Ham's F12， Containing 10-20% FCS, 100 IU/ml penicillin, 100ug/ml streptomycin, CO25％，O220％ |
| Donor attribute: | UPMM-1 and UPMM-2 come from different donors (both from male Caucasian subjects with primary tumor of monomer 3) |
| Notes: | Karyotyping is performed through traditional GTG banding. See: Nareyeck G et al. Exp Eye Res。 October 2006; 83 (4): 858-64. |
| Storage: | LN2 |
| shipment | dry ice |
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