Lu DOTA-TOC macrocyclic compound

Lu-DOTA-TOC， Lutetium-177 labeled DOTA-Tyr3-octreotide is a radioactive substance widely used in nuclear medicine, primarily for the diagnosis of neuroendocrine disorders (NETs). Here is a detailed analysis of it:

1、 Basic Information

• nameLu DOTA-TOC (DOTA-Tyr3-octreotide labeled with lutetium 177)

• composeDOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) is bound to Tyr3-octreotide and labeled with the radioactive isotope lutetium 177.

2、 Structural characteristics

• DOTA acts as a chelating agent and can stably bind with radioactive isotopes such as lutetium 177 to form radiolabeled compounds with specific properties.

• The Tyr3 octreotide moiety is a high affinity receptor ligand that can specifically bind to cells expressing the receptor.

3、 Nature and Function

1. high specificityLu DOTA-TOC can bind to receptor positive cells with high specificity, which makes it highly accurate in the diagnosis and treatment of neuroendocrine disorders.

2. strong affinityDue to the introduction of Tyr3, the affinity of Lu DOTA-TOC for * * * receptors has been significantly improved, thereby enhancing its binding ability to * * cells.

3. High energy beta particle emissionLutetium-177 can emit high-energy beta particles, which have a cytotoxic effect on * * cells, thereby achieving control over * * and * *.

4. Low side effectsDue to the high specificity and affinity of Lu DOTA-TOC, it can accurately deliver radioactive isotopes to * * cells, thereby reducing damage to normal cells and minimizing side effects.

Origin: Xi'an

Packaging: Bottled

Specification: 1mg, 5mg, 10mg

Manufacturer: Xi'an Huirui Biotechnology Co., Ltd

Purpose: Scientific research

Characteristics: Solid/Powder/Solution

Kind reminder: For scientific research only, not for human experiments

Manufacturer Introduction: Xi'anHuiruiBiotechnology Co., Ltd. is a high-tech enterprise that integrates research and development, production, and sales. It can provide synthetic phospholipids, polymer polyethylene glycol derivatives, block copolymers, paramagnetic/superparamagnetic nanoparticles, near-infrared fluorescent dyes, protein crosslinkers, small molecule PEG derivatives, click chemistry products, cyclodextrin derivatives, macrocyclic ligands, and more, to meet the customized needs of different customers.

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