Human aortic smooth muscle cell line

Introduction to human aortic smooth muscle cell line

Although primary human aortic smooth muscle cells can more accurately reflect the physiological state of aortic smooth muscle cells in the human body, on the one hand, human aortic tissue is very precious, and primary isolation and cultivation of human aortic smooth muscle cells have a long cycle and require high technical experience. On the other hand, these primary cells cannot be passaged multiple times in vitro, which restricts their widespread application in the laboratory. The research team of Xinrun Biology has years of experience in primary cell isolation, culture, and cell immortalization services, and has successfully established immortalized human aortic smooth muscle cells.

Aortic smooth muscle cells are the main components that make up the aortic media. When the cell density is low, they often interweave into a network, while when the cell density is high, they are arranged in a vortex or fence like pattern. A major factor in the occurrence and development of vascular diseases is the transformation of vascular smooth muscle cells into phenotypes with proliferative ability. Recent studies have shown that smooth muscle cells can express calcium ion channels, ICAM-1, and VCAM-1. The expression of ICAM-1 and VCAM-1 may be the cause of vascular wall inflammation and further contribute to vascular diseases. Therefore, in vitro culture and research of vascular smooth muscle cells can be used to discover and determine targeted therapies for new vascular diseases.Human aortic smooth muscle cellsDerived from primary human aortic smooth muscle cells.

Our company produces immortalized human aortic smooth muscle cells using enzymatic hydrolysis and gene transfectionPrepared, with a total cell count of approximately 1 × 106/T25 square bottleThe cell purity can reach over 90% and does not contain HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, fungi, etc.

Culture medium information:

We recommend using the product developed by Xinrun BiotechnologyHuman aortic smooth muscle cell lineCulture medium (product code: IH1010-5) for in vitro cultivationHuman aortic smooth muscle cell lineThe cultivation medium.