Full stack high-throughput mRNA/LNP screening and preparation system

Equipment Introduction

XNano™ HT-Smart

Full stack high-throughput mRNA/LNP screening workstation (model XNano™); HT-Smart， The following text is replaced by the model numberA groundbreaking, end-to-end high-throughput microfluidic screening workstation that truly covers the entire process.

The system is equipped with XPure™ Felix automatic dispensing module XNano™ Microfluidic LNP preparation module and XPure™ The Mini high-throughput purification module enables automated preparation of high-throughput formulations from lipid mixing to mRNA LNP end products throughout the entire process. Meet the high-throughput in vivo/in vitro screening requirements for large-scale cationic lipid screening, mRNA/LNP lipid formulation optimization, mRNA sequence screening, and mRNA/LNP preparation process optimization.

This device is suitable for the early research stage in the laboratory.

• Preparation of 96 lipid mixtures< 30min

  
  

• Synthesis of 96 LNP formulations<3hrEach sample can have its own preparation parameters set

  
  

• High throughput two-step cycle purification technology

  
  

• Preparation volume:300ul-1ml (2ml optional)

  
  

• Equipped with low and high temperature module, air filtration system and ultraviolet disinfection and sterilization system

  
  

• Hybrid technology can be usedMicrofluidic chip or T-mix

  
  

• Can seamlessly connect with the subsequent amplification production platform

  
  

• Built in AI algorithm, "foolproof" one click intelligent operation

XNano HT Smart adopts advanced automated microfluidic technology to achieve efficient formulation of different lipid nanoparticle prescriptions.96 parallel prepared commercially available prescriptions (SM-102 LNP and ALC-0315 LNP)The results of physical and chemical properties indicate that there is a high degree of repeatability between sample batches,Particle size and PDI fluctuation<25%.

XNano HT Smart is completing48 SM-102 LNPAfter encapsulating eGFP mRNA in the prescription, ethanol can be removed from mRNA/LNP through a high-throughput online automatic purification moduleThe particle size and PDI of 48 SM-102 mRNA/LNPs maintain a high degree of consistencyThis fully demonstrates the accuracy and stability of the high-throughput online automatic purification system.

The prescriptions screened by XNano HT Smart can be found on INano&trade; And XNano&trade; seriesPreparation of mRNA/LNP nanoparticles with consistent physical and chemical properties on amplification equipmentProvide efficient and cost-effective solutions for the research and development process.

Compared to traditional microfluidic control backup devices, XNano&trade; HT-SmartWith lower usage costs and time investmentHelp you significantly save on research and development expenses.