DSI BUXCO Whole Body Volumetric Breathing

Respiratory and Pulmonary Function Testing System

Awakening Experimental Animal Detection System - WBP (Whole Body Volume)

The WBP (Whole Body Plehysmography) whole body plethysmography detection system is used to monitor the respiratory and lung function of experimental animals in conscious, free range of motion, unconstrained, and non anesthetized states. It is one of the core group trials for safety pharmacology GLP. Apply Halcyon ® Noise reduction technology, Pneumotachs can accurately detect subtle pressure changes caused by airflow flowing inside and outside the chamber. The FinePointe software platform performs professional derivation and analysis of corresponding signals and data, providing professional and accurate respiratory function related parameters such as tidal volume and bronchoconstriction. There is an optional chamber with a Tower at the top, which supports simultaneous blood collection and medication administration.


Applicable species: mice, rats, guinea pigs, rabbits, ferrets, dogs, cats, monkeys, birds, pigs, etc.

Animals larger than guinea pigs need to be equipped with QT signal modulators, flow sensors, respiratory volume chambers, and other devices to detect respiratory signals.


Halcyon ® Noise reduction technology

Applied to the DSI Buxco full platform respiratory plethysmography chamber, it helps to reduce internal vibration interference caused by the free movement of experimental animals, as well as noise caused by other air disturbances such as door closing and air ventilation ducts. After verification, its noise reduction effect can reach more than 20 times. By using two detection ports with built-in sensors in the cavity, this technology can detect signals leading to the animal chamber and the control chamber separately, distinguish external interference signals from signals generated by animal respiration, thereby eliminating noise signals and greatly improving the accuracy of detection systems such as WBP and Functional Resi duality.

WBP system features:

• Can monitor up to 16 animals simultaneously, with dual chamber and four chamber controllers available for flexible configuration
Automated control bias current meter integrated with software
Pre calibrated digital temperature and humidity signals
• Standard nebulization drug delivery controller
• Standard gas automation function
The detachable controller design further enhances the flexibility of system configuration (only applicable to four chamber controllers)
One click can achieve fully automatic calibration of up to 4 chambers simultaneously
Automated microprocessor control system diagnosis
• Can be integrated with other related research - such as fluid rotors, electronic commutators, and optogenetic LEDs

Advantages of WBP system:

• Automatic diagnosis - The microprocessor automatically diagnoses the entire system to ensure data accuracy
Intelligent integration technology - two-way communication ensures the accuracy and reproducibility of scientific data
• Automatic Calibration - One click automated quick calibration to avoid manual errors
The cavity adopts Halcyon ® Noise reduction technology
• Nebulization dosing calibration - avoids differences in dosing efficiency among different controllers
During the exposure process, the bias current can be automatically reduced
• Bias current meter noise reduction technology - improving signal-to-noise ratio
Finepointe software - professional integration of multiple respiratory related studies and automatic report generation function
The software can automatically control the release of up to 4 different gases into the animal breathing chamber through a bias tube

Main parameters of WBP system:
Degree of bronchial stenosis (PenH and Pause), status of airway inflammation (TB and TP), respiratory rate, tidal volume, minute ventilation, peak inspiratory flow rate, peak expiratory flow rate, expiratory flow rate at 50% ventilation, breathing relaxation time, inspiratory duration, expiratory duration, end expiratory pause time, end inspiratory pause time, number of sighs, proportion of sighs, proportion of sniffing, number of sleep apnea, duration of sleep apnea, proportion of sleep apnea, number of sleep apnea types 0/1/2, etc.

WBP single system can achieve multiple applications and derived parameters

• Asthma
• Lung fibrosis
Chronic obstructive pulmonary disease (COPD)
Acute Respiratory Disorders
• Model Development
• Safety Assessment
• Toxicology

Combination application of WBP and other systems

• Optogenetics - Neurocontrol of respiration
• Transducers - Simultaneously collect wired bioelectric potential (EEG, EMG, EOG) signals
• Flexible universal head - for drug administration, pain management, blood collection, or creating injury models
• Implantable telemetry - collecting cardiovascular or central nervous system signals to evaluate overall effects and multi organ interactions