Biotin-GSH, Biotin Glutathione

Biotin-GSH, Biotin GlutathioneIt is a functional complex formed by covalent bonding between biotin and glutathione (GSH), which has shown significant value in biomedical research, drug delivery, and antioxidant therapy.

1、 Chemical composition

• 谷胱甘肽 （GSH）A tripeptide composed of glutamic acid (Glu), cysteine (Cys), and glycine (Gly), with gamma glutamyl bonds connecting glutamic acid and cysteine in its molecular structure, and normal peptide bonds connecting cysteine and glycine, forming a gamma Glu Cys Gly tripeptide structure. Among them, the thiol group (- SH) on cysteine is an important reaction site for GSH, with strong reducibility and nucleophilicity.

• BiotinAlso known as vitamin H or vitamin B7, it is a heterocyclic compound with a tetrahydrothiophene ring and an imidazolidinone ring, and a valeric acid side chain at the end of the molecule. It can participate in chemical reactions such as amidation or esterification through carboxyl groups.

• Combination methodUsually, stable amide bonds are formed by the amidation reaction between the amino groups (especially the N-terminal amino groups) on GSH molecules and the active ester groups in active esterified biotin (such as NHS biotin).

2、 Functional characteristics

• High affinity labeling abilityThe biotin moiety provides high affinity non covalent binding ability (Kd~10 ^ -15 M) with avidin or streptavidin, making Biotin GSH significantly advantageous in biomarker and molecular probe construction.

• Bioreduction activityGSH partially retains its original hydrophilicity and thiol reducing function, which can exert antioxidant and detoxifying effects, clear free radicals in the body, and protect cells from oxidative damage.

• versatilityBiotin GSH can be used for various biometric platforms, such as surface immobilization, enzyme-linked detection, fluorescence tracking, targeted delivery, etc., and has broad application prospects.

3、 Application Fields

• Protein affinity purificationEnrichment and purification of target proteins can be achieved through the affinity of biotin, and enzymes or proteins with biotin binding ability can also be combined in analysis and detection.

• Drug delivery systemBy utilizing the specific binding of biotin and avidin, a targeted drug delivery system is constructed to achieve precise drug release and efficient utilization.

• Antioxidant therapyBiotin GSH can be used as an antioxidant to treat various oxidative stress-related diseases. Its antioxidant effect is mainly achieved through the GSH component, which can clear free radicals in the body and reduce the damage of oxidative stress to cells.

• bioimagingCombined with fluorescein labeled avidin, Biotin GSH can be used to construct biological imaging probes for fluorescence imaging in cells or tissues. For example, in fluorescence microscopy imaging, target molecules are labeled with Biotin GSH and their distribution and dynamic changes are observed through fluorescence signals.

Biotin-GSH, Biotin Glutathione

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